Definitions, variants, and causes of nonadherence with medication: A challenge for tailored interventions

Patient Preference and Adherence

Volumn 7, Issue , 2013, Pages 675-682

  Hugtenburg, Jacqueline G ^a   Timmers, Lonneke ^a   Elders, Petra J M ^a   Vervloet, Marcia ^b   van Dijk, Liset ^b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NETHERLANDS INSTITUTE FOR HEALTH SERVICES RESEARCH   (Netherlands)

Author keywords

Adherence; Compliance; Concordance; Tailored intervention

Indexed keywords

ALUMINUM; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; IRON SALT; MAGNESIUM; TETRACYCLINE DERIVATIVE;

BEHAVIOR CHANGE; DECISION MAKING; HUMAN; INTERNET; INTERPERSONAL COMMUNICATION; MEDICATION COMPLIANCE; MEDICATION NONADHERENCE; MOTIVATION; OUTCOME ASSESSMENT; PATIENT COUNSELING; POLYPHARMACY; PRESCRIPTION; REVIEW; TEXT MESSAGING;

EID: 84880123677     PISSN: None     EISSN: 1177889X     Source Type: Journal    
DOI: 10.2147/PPA.S29549     Document Type: Review

References (52)

1. Vrijens B, De Geest S, Hughes DA, etal. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691-705.
2. Wroe AL. Intentional and unintentional nonadherence: a study of decision making. J Behav Med. 2002;25(4):355-372.
3. Lehane E, McCarthy G. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. Int J Nurs Stud. 2007;44(8):1468-1477.
4. Lowry KP, Dudley TK, Oddone EZ, Bosworth HB. Intentional and unintentional nonadherence to antihypertensive medication. Ann Pharmacother. 2005;39(7-8):1198-1203.
5. Clifford S, Barber N, Horne R. Understanding different beliefs held by adherers, unintentional nonadherers, and intentional nonadherers: application of the Necessity-Concerns Framework. J Psychosom Res. 2008;64(1):41-46.
6. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007;120(8):713-719.
7. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001; 23(8):1296-1310.
8. Linn AJ, van Weert JC, Smit EG, Schouten BC, Van Bodegraven A, Van Dijk L. Words that make pills easier to swallow: a communication typology to address practical and perceptual barriers to medication intake behavior. Patient Prefer Adherence. 2012;6:871-885.
9. van Dulmen S, van Bijnen E. What makes them (not) talk about proper medication use with their patients? An analysis of the determinants of GP communication using reflective practice. Int J Pers Cent Med. 2011;1:27-34.
10. van Dulmen S, Sluijs E, van Dijk L, de Ridder D, Heerdink R, Bensing J. Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res. 2007;7:55.
11. Nilsson JLG, Andersson K, Bergkvist A, Bjorkman I, Brismar A, Moen J. Refill adherence to repeat prescriptions of cancer drugs to ambulatory patients. Eur J Cancer Care (Engl). 2006;15(3):235-237.
12. Ruddy K, Mayer E, Partridge A. Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin. 2009;59(1):56-66.
13. Noens L, van Lierde MA, De Bock R, etal. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: the ADAGIO study. Blood. 2009;113(22): 5401-5411.
14. Marin D, Bazeos A, Mahon F, etal. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib. J Clin Oncol. 2010;28(14):2381-2388.
15. Jabbour EJ, Kantarjian H, Eliasson L, Cornelison AM, Marin D. Patient adherence to tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Am J Hematol. 2012;87(7):687-691.
16. Partridge AH, Archer L, Kornblith AB, etal. Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: adherence companion study 60104. J Clin Oncol. 2010;28(14):2418-2422.
17. Ruddy KJ, Partridge AH. Adherence with adjuvant hormonal therapy for breast cancer. Ann Oncol. 2009;20(3):401-402.
18. Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43(6):521-530.
19. Roebuck MC, Liberman JN, Gemmill-Toyama M, Brennan TA. Medication adherence leads to lower health care use and costs despite increased drug spending. Health Aff (Millwood). 2011;30(1):91-99.
20. Dragomir A, Cote R, Roy L, etal. Impact of adherence to antihypertensive agents on clinical outcomes and hospitalization costs. Med Care. 2010;48(5):418-425.
21. Faught RE, Weiner JR, Guerin A, Cunnington MC, Duh MS. Impact of nonadherence to antiepileptic drugs on health care utilization and costs: findings from the RANSOM study. Epilepsia. 2009;50(3):501-519.
22. Esposito D, Bagchi AD, Verdier JM, Bencio DS, Kim MS. Medicaid beneficiaries with congestive heart failure: association of medication adherence with healthcare use and costs. Am J Manag Care. 2009;15(7): 437-445.
23. Halpern R, Becker L, Iqbal SU, Kazis LE, Macarios D, Badamgarav E. The association of adherence to osteoporosis therapies with fracture, all-cause medical costs, and all-cause hospitalizations: a retrospective claims analysis of female health plan enrollees with osteoporosis. J Manag Care Pharm. 2011;17(1):25-39.
24. Simpson SH, Eurich DT, Majumdar SR, etal. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006;333(7557):15.
25. Steinman MA, Handler SM, Gurwitz JH, Schiff GD, Covinsky KE. Beyond the prescription: medication monitoring and adverse drug events in older adults. J Am Geriatr Soc. 2011;59(8):1513-1520.
26. Booz&co. KNMP-The potential for pharmaceutical quality services. Available from: http://www.knmp.nl/downloads/nieuws/booz-co-the-potential-for-pharmaceutical-quality-services. Accessed April 11, 2013.
27. Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008;2:CD000011.
28. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA. 2002;288(22):2868-2679.
29. Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167(6):540-550.
30. Linn AJ, Vervloet M, Van Dijk L, Smit EG, van Weert JC. Effects of eHealth interventions on treatment adherence: a systematic review of all literature. J Med Internet Res. 2011;13(4):103.
31. Vervloet M, Linn AJ, van Weert JC, de Bakker DH, Bouvy ML, van DL. The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature. J Am Med Inform Assoc. 2012;19(5):696-704.
32. van Dulmen S, Sluijs E, van Dijk L, etal. Furthering patient adherence: a position paper of the international expert forum on patient adherence based on an internet forum discussion. BMC Health Serv Res. 2008;8:47.
33. Sabaté E. Adherence to Long-Term Therapies. Evidence for Action. Geneva, Switzerland: World Health Organization; 2003.
34. Haynes RB, Taylor DW, Sackett DL. Compliance in Health Care, 1st ed. Baltimore, MD: John Hopkins University Press; 1979.
35. ABC Project Team. Ascertaining barriers for compliance: policies for safe, effective and cost-effective use of medicines in Europe. Final report of the ABC project. Available from: http://abcproject.eu/img/ABC%20Final.pdf. Accessed April 11, 2013.
36. Cramer JA, Roy A, Burrell A, etal. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1): 44-47.
37. Bell JS, Airaksinen MS, Lyles A, Chen TF, Aslani P. Concordance is not synonymous with compliance or adherence. Br J Clin Pharmacol. 2007;64(5):710-711.
38. Urquhart J, Vrijens B. New findings about patient adhernce to prescribed drug dosing regimens: an introduction to pharmionics. Eur J Hosp Pharm Sci. 2005;11:103-106.
39. van Geffen EC, Gardarsdottir H, van Hulten R, van Dijk L, Egberts AC, Heerdink ER. Initiation of antidepressant therapy: do patients follow the GP's prescription? Br J Gen Pract. 2009;59(559):81-87.
40. Royal Pharmaceutical Society of Great Britain and Merck Sharp and Dohme. Partnership in Medicine Taking: A Consultative Document. London, UK: Royal Pharmaceutical Society of Great Britain and Merck Sharp and Dohme; 1996.
41. Horne R, Weinman J, Barber N, Elliot R, Morgan M. Adherence and Compliance in Medicine Taking. Report for the National Coordinating Centre for NHS Service Delivery and Organization R and D (NCCSDO). Available from: http://www.sdo.lshtm.ac.uk/files/project/76-final-report.pdf. Accessed April 11, 2013.
42. van Dijk L, Heerdink ER, Somai D, etal. Patient risk profiles and practice variation in nonadherence to antidepressants, antihypertensives and oral hypoglycemics. BMC Health Serv Res. 2007;7:51.
43. Zedler BK, Kakad P, Colilla S, Murrelle L, Shah NR. Does packaging with a calendar feature improve adherence to self-administered medication for long-term use? A systematic review. Clin Ther. 2011; 33(1):62-73.
44. Ericsson. Traffic and Market Report. On the Pulse of Network Society. Available from: http://www.ericsson.com/res/docs/2012/traffic_and_market_report_june_2012.pdf. Accessed April 11, 2013.
45. Cocosila M, Archer N. A framework for mobile healthcare answers to chronically ill outpatient non-adherence. Inform Prim Care. 2005;13(2):145-152.
46. Vervloet M, van Dijk L, Santen-Reestman J, etal. SMS reminders improve adherence to oral medication in type 2 diabetes patients who are real time electronically monitored. Int J Med Inform. 2012;81(9): 594-604.
47. Rollnick S, Butler CC, Kinnersley P, Gregory J, Mash B. Motivational interviewing. BMJ. 2010;340:c1900.
48. Rubak S, Sandbaek A, Lauritzen T, Christensen B. Motivational interviewing: a systematic review and meta-analysis. Br J Gen Pract. 2005;55(513):305-312.
49. DiMatteo MR, Haskard-Zolnierek KB, Martin LR. Improving patient adherence: a three-factor model to guide practice. Health Psychol Rev. 2012;6(1):74-91.
50. Herborg H, Haugbolle LS, Sorensen L, Rossing C, Dam P. Developing a generic, individualised adherence programme for chronic medication users. Pharm Pract. 2008;6(3):148-157.
51. Adhien P, Van Dijk L, Vegter M, Westein M, Nijpels G, Hugtenburg JG. Interventie op maat bij therapie-ontrouwe diabetespatienten; kwalitatief onderzoek naar de uitvoerbaarheid van de interventie. Pharmaceutisch Weekblad. 2012;147(1):2-6. German.
52. Lustria ML, Cortese J, Noar SM, Glueckauf RL. Computer-tailored health interventions delivered over the web: review and analysis of key components. Patient Educ Couns. 2009;74(2):156-173.