Evaluation of antiviral efficacy against human respiratory syncytial virus using cotton rat and mouse models

Methods in Molecular Biology

Volumn 1030, Issue , 2013, Pages 365-372

  Van Den Berg, Joke ^a   Kwanten, Leen ^a   Roymans, Dirk ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Balb c mice; Cotton rat; hRSV inhibitors; Human respiratory syncytial virus

Indexed keywords

ANTIVIRUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COTTON RAT; CULTURE MEDIUM; DRUG EFFICACY; DRUG MEGADOSE; DRUG SCREENING; FEMALE; IN VIVO STUDY; LOW DRUG DOSE; LUNG LAVAGE; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DISEASE MODELS, ANIMAL; HUMANS; MICE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; SIGMODONTINAE; VERO CELLS; VIRAL LOAD; VIRAL PLAQUE ASSAY;

EID: 84880110586     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-484-5_28     Document Type: Article

References (24)

1. Chanock R, Roizman B, Myers R (1957) Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). I. Isolation, properties and characterization. Am J Hyg 66:281-290
2. Chanock R, Finberg L (1957) Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Am J Hyg 66:291-300
3. Ruuskanen O, Lahti E, Jennings LC et al (2011) Viral pneumonia. Lancet 377:1264-1275
4. Nair H, Nokes JD, Gessner BD et al (2010) Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and metaanalysis. Lancet 375:1545-1555
5. Collins PL, Crowe JE Jr (2007) Respiratory syncytial virus and metapneumovirus. In: Knipe DM, Howley PM (eds) Fields virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1601-1646
6. Hall CB, Weinberg GA, Iwane MK et al (2009) The burden of respiratory syncytial virus in young children. New Engl J Med 360:588-598
7. Couch RB, Englund JA, Whimbey E (1997) Respiratory viral infections in immunocompetent and immunocompromised persons. Am J Med 102:2-9
8. Falsey AR, Hennessey PA, Formica MA et al (2005) Respiratory syncytial virus infection in the elderly and high-risk adults. New Engl J Med 352:1749-1759
9. Rudan I, Boschi-Pinto C, Biloglav Z et al (2008) Epidemiology and etiology of childhood pneumonia. Bull World Health Organ 86:408-416
10. Simoes EAF (1999) Respiratory syncytial virus infection. Lancet 354:847-852
11. Thompson WW, Shay DK, Weintraub E et al (2003) Mortality associated with infl uenza and respiratory syncytial virus in the United States. J Am Med Assoc 289:179-186
12. Falsey AR, Walsh EE (2000) Respiratory syncytial virus infection in adults. Clin Microbiol Rev 13:371-384
13. Roymans D, Koul A (2011) Treatment of respiratory syncytial virus infection: past, present and future. In: Resch B (ed) Human respiratory syncytial virus infection. InTech Europe, Rijeka, pp 197-234
14. Roymans D, Koul A (2010) Respiratory syncytial virus: a prioritized or neglected target? Future Med Chem 2:1523-1527
15. Byrd LG, Prince GA (1997) Animal models of respiratory syncytial virus infection. Clin Infect Dis 25:1363-1368
16. Bem RA, Domachowske JB, Rosenberg HF (2011) Animal models of human respiratory syncytial virus disease. Am J Physiol Lung Cell Mol Physiol 301:L148-L156
17. Boukhvalova MS, Prince GA, Blanco JCG (2009) The cotton rat model of respiratory viral infections. Biologicals 37:152-159
18. Rouan M-C, Gevers T, Roymans D et al (2010) Pharmacokinetics- pharmacodynamics of a respiratory syncytial virus fusion inhibitor in the cotton rat model. Antimicrob Agents Chemother 54:4534-4539
19. Olszewska W, Ispas G, Schnoeller C et al (2011) Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model. Eur Respir J 38:401-408
20. Wyde PR, Chetty SN, Timmerman P et al (2003) Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res 60:221-231
21. Bonfanti JF, Roymans D (2009) Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel 12:479-487
22. Cianci C, Genovesi EV, Lamb L et al (2004) Oral effi cacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother 48:2448-2454
23. Bonfanti JF, Meyer C, Doublet F et al (2008) Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121). J Med Chem 51:875-896
24. Ventre K, Randolph AG (2007) Ribavirin for respiratory syncytial virus infection of the lower respiratory tract in infants and young children. Cochrane Database Syst Rev 1:CD000181