Successful use of locally applied polyhexamethylene biguanide as an adjunct to the treatment of fungal osteomyelitis

Canadian Journal of Infectious Diseases and Medical Microbiology

Volumn 24, Issue 2, 2013, Pages 109-112

  Walls, Genevieve ^a   Noonan, Lisa ^a   Wilson, Elizabeth ^b   Holland, David ^c   Briggs, Simon ^a  

^a AUCKLAND CITY HOSPITAL   (New Zealand)

^b STARSHIP CHILDREN S HOSPITAL   (New Zealand)

^c MIDDLEMORE HOSPITAL   (New Zealand)

Author keywords

Fungal osteomyelitis; Fusarium solani; Polyhexamethylene biguanide; Scedosporium prolificans

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AMPHOTERICIN B; FLUCYTOSINE; ITRACONAZOLE; KETOCONAZOLE; MICONAZOLE; POLY(HEXAMETHYLENEBIGUANIDE); POSACONAZOLE; TERBINAFINE; VORICONAZOLE;

ACHILLES TENDON; ADULT; ARTICLE; BACTERIUM CULTURE; BONE BIOPSY; BONE INFECTION; CASE REPORT; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DEBRIDEMENT; DRUG EFFICACY; FEMALE; FUSARIOSIS; FUSARIUM; FUSARIUM SOLANI; HEEL PAIN; HEEL SPUR; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENCE; LEG SWELLING; LOADING DRUG DOSE; MALE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOMYELITIS; PRESCHOOL CHILD; SCEDOSPORIUM; SCEDOSPORIUM APIOSPERMUM; TREATMENT RESPONSE; TRICHODERMA; X RAY;

EID: 84880078896     PISSN: 17129532     EISSN: None     Source Type: Journal    
DOI: 10.1155/2013/508908     Document Type: Article

References (18)

1. Berbari EF, Steckelberg JM, Osmon DR. Bone and joint infections: Osteomyelitis. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone, 2010:1457-67.
2. Steinbach WJ, Schell WA, Miller JA, Perfect JR. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. J Clin Microbiol 2003;41:3981-5.
3. Chang CY, Schell WA, Perfect JR, Hulka GF. Novel use of a swimming pool biocide in the treatment of rare fungal mastoiditis. Laryngoscope 2005;115:1065-9.
4. Sierra-Hoffman M, Paltiyevich-Gibson S, Carpenter JL, Hurley DL. Fusarium osteomyelitis: Case report and review of the literature. Scand J Infect Dis 2005;37:237-40.
5. Cefrulo CL, Leto Barone AA, Jordan K, et al. A multi-disciplinary approach to the management of fungal osteomyelitis: Current concepts in post-traumatic lower extremity reconstruction: A case report. Microsurgery 2012;32:144-7.
6. Swenson JA, Patel JB, Jorgensen JH. Special phenotype methods for detecting antibacterial resistance. In: Versalovic J, Carroll KC, Funke G, Jorgensen JH, Landry ML, Warnock DW, eds. Manual of Clinical Microbiology. Washington DC: ASM Press, 2011:1155-79.
7. Kooijman CM, Kampinga GA, De Hoog GS, Goudswaard WB, Reijnen MM. Successful treatment of Scedosporium aurantiacum osteomyelitis in an immunocompetent patient. Surg Infect 2007;8:605-10.
8. Kesson AM, Bellemore MC, O'Mara TJ, Ellis DH, Sorrell TC. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with a novel agent, hexadecylphospocholine (Miltefosine), in combination with terbinafine and voriconazole: A case report. Clin Infect Dis 2009;48:1257-61.
9. Weinberg WG, Wade BH, Cierney G, Stacy D, Rinaldi MG. Invasive infection due to Apophysomyces elegans in immunocompetent hosts. Clin Infect Dis 1993;17:881-4.
10. Stratov I, Korman TM, Johnson PD. Management of Aspergillus osteomyelitis: Report of failure of liposomal amphotericin B and response to voriconazole in an immunocompetent host and literature review. Eur J Clin Microbiol Infect Dis 2003;22:277-83.
11. Su CT, Chen LK, Tsai YF, Kuo CJ, Lu CL, Chen HY. Disseminated cryptococcosis with pulmonary and marrow involvement mimicking radiological features of malignancy. J Chin Med Assoc 2004;67:89-92.
12. Karuppal R, Kumaran CM, Marthya A, et al. Tibial osteomyelitis due to Fonsecaea pedrosoi in an immunocompetent patient: Case report. J Foot Ankle Surg 2009;48:569-72.
13. Appenzeller S, Amaral TN, Amstalden EM, et al. Sporothrix schenckii infection presenting as monoarthritis: Report of two cases and review of the literature. Clin Rheumatol 2006;25:926-8.
14. Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: Diagnosis and treatment update 2009. Am J Ophthalmol 2009;148:487-99.
15. Rebong RA, Santaella RM, Goldhagan BE, et al. Polyhexamethylene biguanide and calcineurin inhibitors as novel anti-fungal treatments for Aspergillus keratitis. Invest Ophthalmol Vis Sci 2011;52:7309-15.
16. McDonnell G, Denver Russell A. Antiseptics and disinfectants: Activity, action and resistance. Clin Microbiol Rev 1999;12:147-79.
17. Messick CR, Pendland SL, Moshirfar M, et al. In vitro activity of polyhexamethylene biguanide (PHMB) against fungal isolates associated with infective keratitis. J Antimicrob Chemother 1999;44:297-8.
18. Hubner NO, Kramer A. Review on the efficacy, safety and clinical applications of polihexanide, a modern wound antiseptic. Skin Pharmacol Physiol 2010;23(SUPPL. 1):17-27.