Plasma, oral fluid, and whole-blood distribution of antipsychotics and metabolites in clinical samples

Therapeutic Drug Monitoring

Volumn 35, Issue 3, 2013, Pages 345-351

  Fisher, Danielle S ^a   Van Schalkwyk, Gerrit I ^b   Seedat, Soraya ^b   Curran, Sarah R ^c   Flanagan, Robert J ^a  

^a KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF STELLENBOSCH   (South Africa)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antipsychotics; Oral fluid; Plasma:oral fluid distribution; Plasma:whole blood distribution; TDM

Indexed keywords

AMISULPRIDE; ARIPIPRAZOLE; CLOZAPINE; DRUG METABOLITE; NEUROLEPTIC AGENT; QUETIAPINE; RISPERIDONE; SULPIRIDE;

ADULT; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG MONITORING; FEMALE; FLUID INTAKE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PH; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; SALIVA ANALYSIS; TANDEM MASS SPECTROMETRY;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; CHROMATOGRAPHY, LIQUID; DRUG MONITORING; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; SALIVA; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84880073801     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e318283eaf2     Document Type: Article

References (24)

1. Almandil NB, Wong IC. Review on the current use of antipsychotic drugs in children and adolescents. Arch Dis Child Educ Pract Ed. 2011;96:192-196.
2. Gyllenberg D, Sourander A, Helenius H, et al. Childhood predictors of antipsychotic use among young people in Finland. Pharmacoepidemiol Drug Saf. 2012;21:964-971.
3. Harrison JN, Cluxton-Keller F, Gross D. Antipsychotic medication prescribing trends in children and adolescents. J Pediatr Health Care. 2012; 26:139-145.
4. Seida JC, Schouten JR, Boylan K, et al. Antipsychotics for children and young adults: a comparative effectiveness review. Pediatrics. 2012;129: e771-784.
5. Pichini S, Papaseit E, Joya X, et al. Pharmacokinetics and therapeutic drug monitoring of psychotropic drugs in pediatrics. Ther Drug Monit. 2009;31:283-318.
6. Aman MG, Vinks AA, Remmerie B, et al. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clin Ther. 2007;29:1476-1486. (Pubitemid 47348123)
7. Drummer OH. Drug testing in oral fluid. Clin Biochem Rev. 2006;27: 147-159.
8. Rai B. Oral fluid in toxicology. The Internet Journal of Toxicology [serial online]. 2007;3. Available at: http://www.ispub.com:80/journal/ theinternet-journal-of-toxicology/volume-3-number-2/oral-fluid-in-toxicology. html. Accessed September 19, 2012.
9. Flarakos J, Luo W, Aman M, et al. Quantification of risperidone and 9-hydroxyrisperidone in plasma and saliva from adult and paediatric patients by liquid chromatography-mass spectrometry. J Chromatogr A. 2004;1026:175-183. (Pubitemid 38045278)
10. Spiehler V. Drugs in saliva. In: Moffat C, Osselton M, Widdop B, eds. Clarke's Analysis of Drugs and Poisons. 3rd ed. London, United Kingdom: Pharmaceutical Press; 2004:109-123.
11. Crouch DJ, Day D, Baudys J, et al. Evaluation of saliva/oral fluid as an alternate drug testing specimen. NIJ Rep 605-03 [serial online]. 2005. Available at: https://www.ncjrs.gov/App/Publications/abstract.aspx? ID=203569. Accessed September 19, 2012.
12. Gallardo E, Queiroz JA. The role of alternative specimens in toxicological analysis. Biomed Chromatogr. 2008;22:795-821.
13. Gröschl M, Köhler H, Topf H-G, et al. Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J Pharm Biomed Anal. 2008;47:478-486.
14. Salimetrics. Saliva Collection and Handling Advice [Salimetrics website]. 2011. 2nd ed. Available at: http://www.salimetrics.com/documents/Saliva- Collection-Handbook.pdf. Accessed on September 19, 2012.
15. Horning MJ, Brown L, Nowlin J, et al. Use of saliva in therapeutic drug monitoring. Clin Chem. 1977;23:157-164. (Pubitemid 8055738)
16. Saar E, Gerostamoulos D, Drummer OH, et al. Assessment of the stability of 30 antipsychotic drugs in stored blood specimens. Forensic Sci Int. 2012;215:152-158.
17. Flanagan RJ, Yusufi B, Barnes TR. Comparability of whole-blood and plasma clozapine and norclozapine concentrations. Br J Clin Pharmacol. 2003;56:135-138. (Pubitemid 36886500)
18. Nemecek R, Miholic J, Schmid RW. Comparing serum to saliva acetaminophen kinetics. Ther Drug Monit. 2011;33:556.
19. Fisher DS, Handley SA, Flanagan RJ, et al. Plasma concentrations of quetiapine, N-desalkylquetiapine, O-desalkylquetiapine, 7-hydroxyquetiapine, and quetiapine sulfoxide in relation to quetiapine dose, formulation, and other factors. Ther Drug Monit. 2012; 34:415-421.
20. Saracino MA, de Palma A, Boncompagni G, et al. Analysis of risperidone and its metabolite in plasma and saliva by LC with coulometric detection and a novel MEPS procedure. Talanta. 2010;81: 1547-1553.
21. Mandrioli R, Mercolini L, Lateana D, et al. Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879: 167-173.
22. de Castro A, Concheiro M, Quintela O, et al. LC-MS/MS method for the determination of nine antidepressants and some of their main metabolites in oral fluid and plasma. Study of correlation between venlafaxine concentrations in both matrices. J Pharm Biomed Anal. 2008;48:183-193.
23. Wille SM, Raes E, Lillsunde P, et al. Relationship between oral fluid and blood concentrations of drugs of abuse in drivers suspected of driving under the influence of drugs. Ther Drug Monit. 2009;31:511-519.
24. Ji QC, Liu G, D'Arienzo CJ, et al. What is next for dried blood spots? Bioanalysis. 2012;4:2059-2065.