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Volumn 129, Issue 3, 2012, Pages

Antipsychotics for children and young adults: A comparative effectiveness review

Author keywords

Antipsychotics; Behavioral disorders; Psychiatric disorders; Systematic review

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; FIRST GENERATION ANTIPSYCHOTIC AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PALIPERIDONE; PIMOZIDE; PLACEBO; QUETIAPINE; RISPERIDONE; SECOND GENERATION ANTIPSYCHOTIC AGENT; UNCLASSIFIED DRUG; ZIPRASIDONE;

EID: 84857952277     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-2158     Document Type: Review
Times cited : (84)

References (111)
  • 4
    • 38049064374 scopus 로고    scopus 로고
    • Psychotropic medication patterns among youth in foster care
    • Available at
    • Zito JM, Safer DJ, Sai D, et al. Psychotropic medication patterns among youth in foster care. Pediatrics. 2008;121(1). Available at: www.pediatrics.org/cgi/content/full/121/1/e157
    • (2008) Pediatrics , vol.121 , Issue.1
    • Zito, J.M.1    Safer, D.J.2    Sai, D.3
  • 5
    • 33846678197 scopus 로고    scopus 로고
    • Patterns and determinants of antipsychotic prescribing in children and adolescents, 2003-2004
    • DOI 10.1185/030079906X158075
    • Aparasu RR, Bhatara V. Patterns and determinants of antipsychotic prescribing in children and adolescents, 2003-2004. Curr Med Res Opin. 2007;23(1):49-56 (Pubitemid 46191669)
    • (2007) Current Medical Research and Opinion , vol.23 , Issue.1 , pp. 49-56
    • Aparasu, R.R.1    Bhatara, V.2
  • 7
    • 44449097249 scopus 로고    scopus 로고
    • Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom
    • Rani F, Murray ML, Byrne PJ, Wong IC. Epidemiologic features of antipsychotic prescribing to children and adolescents in primary care in the United Kingdom. Pediatrics. 2008;121(5):1002-1009
    • (2008) Pediatrics. , vol.121 , Issue.5 , pp. 1002-1009
    • Rani, F.1    Murray, M.L.2    Byrne, P.J.3    Wong, I.C.4
  • 9
    • 33645737575 scopus 로고    scopus 로고
    • Trends in Prescribing of Antipsychotic Medications for US Children
    • DOI 10.1016/j.ambp.2005.11.002, PII S1530156705000201
    • Cooper WO, Arbogast PG, Ding H, Hickson GB, Fuchs DC, Ray WA. Trends in prescribing of antipsychotic medications for US children. Ambul Pediatr. 2006;6(2):79-83 (Pubitemid 43960577)
    • (2006) Ambulatory Pediatrics , vol.6 , Issue.2 , pp. 79-83
    • Cooper, W.O.1    Arbogast, P.G.2    Ding, H.3    Hickson, G.B.4    Fuchs, D.C.5    Ray, W.A.6
  • 10
    • 79953295120 scopus 로고    scopus 로고
    • Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: A systematic review of randomized, placebo controlled trials and guidelines for clinical practice
    • De Hert M, Dobbelaere M, Sheridan EM, Cohen D, Correll CU. Metabolic and endocrine adverse effects of second-generation antipsychotics in children and adolescents: a systematic review of randomized, placebo controlled trials and guidelines for clinical practice. Eur Psychiatry. 2011;26(3):144-158
    • (2011) Eur Psychiatry , vol.26 , Issue.3 , pp. 144-158
    • De Hert, M.1    Dobbelaere, M.2    Sheridan, E.M.3    Cohen, D.4    Correll, C.U.5
  • 11
    • 18744366088 scopus 로고    scopus 로고
    • Second-generation (atypical) antipsychotics and metabolic effects: A comprehensive literature review
    • DOI 10.2165/00023210-200519010-00001
    • Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 2005;19(suppl 1):1-93 Shekelle P, Maglione M, Bagley S, et al. Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics. Comparative Effectiveness Review No. 6. (Prepared by the Southern California/RAND Evidence-based Practice Center under Contract No. 290-02-0003). Rockville, MD: Agency for Healthcare Research and Quality; 2007 (Pubitemid 40677047)
    • (2005) CNS Drugs , vol.19 , Issue.SUPPL. 1 , pp. 1-93
    • Newcomer, J.W.1
  • 12
    • 34247394537 scopus 로고    scopus 로고
    • Management of psychiatric disorders in children and adolescents with atypical antipsychotics: A systematic review of published clinical trials
    • DOI 10.1007/s00787-006-0580-1
    • Jensen PS, Buitelaar J, Pandina GJ, Binder C, Haas M. Management of psychiatric disorders in children and adolescents with atypical antipsychotics: a systematic review of published clinical trials. Eur Child Adolesc Psychiatry. 2007;16(2):104-120 (Pubitemid 46643895)
    • (2007) European Child and Adolescent Psychiatry , vol.16 , Issue.2 , pp. 104-120
    • Jensen, P.S.1    Buitelaar, J.2    Pandina, G.J.3    Binder, C.4    Haas, M.5
  • 13
    • 34247255894 scopus 로고    scopus 로고
    • Use of atypical antipsychotics in the treatment of autistic disorder
    • DOI 10.1345/aph.1H527
    • Stachnik JM, Nunn-Thompson C. Use of atypical antipsychotics in the treatment of autistic disorder. Ann Pharmacother. 2007;41(4):626-634 (Pubitemid 46625485)
    • (2007) Annals of Pharmacotherapy , vol.41 , Issue.4 , pp. 626-634
    • Stachnik, J.M.1    Nunn-Thompson, C.2
  • 15
    • 39749143011 scopus 로고    scopus 로고
    • Antipsychotic medication for childhood-onset schizophrenia
    • CD004027
    • Kennedy E, Kumar A, Datta S. Antipsychotic medication for childhood-onset schizophrenia. Cochrane Database Syst Rev. 2007;(3):CD004027
    • (2007) Cochrane Database Syst Rev , Issue.3
    • Kennedy, E.1    Kumar, A.2    Datta, S.3
  • 16
    • 33645295210 scopus 로고    scopus 로고
    • Antipsychotics in early onset schizophrenia: Systematic review and meta-analysis
    • Armenteros JL, Davies M. Antipsychotics in early onset schizophrenia: systematic review and meta-analysis. Eur Child Adolesc Psychiatry. 2006;15(3):141-148
    • (2006) Eur Child Adolesc Psychiatry. , vol.15 , Issue.3 , pp. 141-148
    • Armenteros, J.L.1    Davies, M.2
  • 17
    • 67849085225 scopus 로고    scopus 로고
    • A systematic review of the quality and impact of anxiety disorder meta-analyses
    • Ipser JC, Stein DJ. A systematic review of the quality and impact of anxiety disorder meta-analyses. Curr Psychiatry Rep. 2009; 11(4):302-309
    • (2009) Curr Psychiatry Rep , vol.11 , Issue.4 , pp. 302-309
    • Ipser, J.C.1    Stein, D.J.2
  • 19
    • 34247394537 scopus 로고    scopus 로고
    • Management of psychiatric disorders in children and adolescents with atypical antipsychotics: A systematic review of published clinical trials
    • DOI 10.1007/s00787-006-0580-1
    • Jensen PS, Buitelaar J, Pandina GJ, Binder C, Haas M. Management of psychiatric disorders in children and adolescents with atypical antipsychotics: a systematic review of published clinical trials. Eur Child Adolesc Psychiatry. 2007;16(2):104-120 (Pubitemid 46643895)
    • (2007) European Child and Adolescent Psychiatry , vol.16 , Issue.2 , pp. 104-120
    • Jensen, P.S.1    Buitelaar, J.2    Pandina, G.J.3    Binder, C.4    Haas, M.5
  • 20
    • 84887346660 scopus 로고    scopus 로고
    • Version 5.0.1 updated September 2008 The Cochrane Collaboration Available at: Accessed September 19, 2011
    • Higgins J, Green S, eds. Cochrane handbook for systematic reviews of interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration 2008. Available at: www.mrc-bsu.cam.ac.uk/cochrane/handbook/front-page.htm. Accessed September 19, 2011
    • (2008) Cochrane Handbook for Systematic Reviews of Interventions
    • Higgins, J.1    Green, S.2
  • 22
    • 39049096171 scopus 로고    scopus 로고
    • Pharmaceutical company funding and its consequences: A qualitative systematic review
    • DOI 10.1016/j.cct.2007.08.001, PII S1551714407001255
    • Sismondo S. Pharmaceutical company funding and its consequences: a qualitative systematic review. Contemp Clin Trials. 2008;29(2):109-113 (Pubitemid 351248768)
    • (2008) Contemporary Clinical Trials , vol.29 , Issue.2 , pp. 109-113
    • Sismondo, S.1
  • 23
    • 77949609822 scopus 로고    scopus 로고
    • AHRQ series paper 5: Grading the strength of a body of evidence when comparing medical interventions-Agency for Healthcare Research and Quality and the effective health-care program
    • Owens DK, Lohr KN, Atkins D, et al. AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions-Agency for Healthcare Research and Quality and the effective health-care program. J Clin Epidemiol. 2010;63(5):513-523
    • (2010) J Clin Epidemiol. , vol.63 , Issue.5 , pp. 513-523
    • Owens, D.K.1    Lohr, K.N.2    Atkins, D.3
  • 24
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • DOI 10.1002/sim.1186
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539-1558 (Pubitemid 34746062)
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 25
    • 84948773232 scopus 로고    scopus 로고
    • Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis
    • Egger M, Davey Smith G, Altman DG, eds. 2nd ed. London, UK: BMJ Publishing Group
    • Deeks J, Altman D, Bradburn M. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M, Davey Smith G, Altman DG, eds. Systematic Review in Health Care: Meta-Analysis in Context. 2nd ed. London, UK: BMJ Publishing Group; 2001:285-312
    • (2001) Systematic Review in Health Care: Meta-Analysis in Context , pp. 285-312
    • Deeks, J.1    Altman, D.2    Bradburn, M.3
  • 26
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315 (7109):629-634 (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 27
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in metaanalysis. Biometrics. 2000;56(2):455-463 (Pubitemid 30422636)
    • (2000) Biometrics , vol.56 , Issue.2 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 31
    • 71449095638 scopus 로고    scopus 로고
    • A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder
    • Marcus RN, Owen R, Kamen L, et al. A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. J Am Acad Child Adolesc Psychiatry. 2009;48(11):1110-1119
    • (2009) J Am Acad Child Adolesc Psychiatry , vol.48 , Issue.11 , pp. 1110-1119
    • Marcus, R.N.1    Owen, R.2    Kamen, L.3
  • 33
    • 39149096262 scopus 로고    scopus 로고
    • Risperidone versus haloperidol in children and adolescents with AD: A randomized, controlled, double-blind trial
    • Miral S, Gencer O, Inal-Emiroglu FN, Baykara B, Baykara A, Dirik E. Risperidone versus haloperidol in children and adolescents with AD : a randomized, controlled, double-blind trial. Eur Child Adolesc Psychiatry. 2008;17(1):1-8
    • (2008) Eur Child Adolesc Psychiatry. , vol.17 , Issue.1 , pp. 1-8
    • Miral, S.1    Gencer, O.2    Inal-Emiroglu, F.N.3    Baykara, B.4    Baykara, A.5    Dirik, E.6
  • 34
    • 33746053489 scopus 로고    scopus 로고
    • Risperidone in children with autism: Randomized, placebo-controlled, double-blind study
    • DOI 10.2310/7010.2006.00099
    • Nagaraj R, Singhi P, Malhi P. Risperidone in children with autism: randomized, placebo-controlled, double-blind study. J Child Neurol. 2006;21(6):450-455 (Pubitemid 44069792)
    • (2006) Journal of Child Neurology , vol.21 , Issue.6 , pp. 450-455
    • Nagaraj, R.1    Singhi, P.2    Malhi, P.3
  • 37
    • 16644370679 scopus 로고    scopus 로고
    • Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders
    • Available at
    • Shea S, Turgay A, Carroll A, et al. Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics. 2004;114(5). Available at: www.pediatrics.org/cgi/content/full/114/5/e634
    • (2004) Pediatrics , vol.114 , Issue.5
    • Shea, S.1    Turgay, A.2    Carroll, A.3
  • 39
    • 56049123920 scopus 로고    scopus 로고
    • Control of psychomotor agitation and aggressive behavior in patients with autistic disorder: A retrospective chart review
    • Novaes CM, Pondé MP, Freire AC. Control of psychomotor agitation and aggressive behavior in patients with autistic disorder: a retrospective chart review. Arq Neuropsiquiatr. 2008;66(3B):646-651
    • (2008) Arq Neuropsiquiatr. , vol.66 , Issue.3 , pp. 646-651
    • Novaes, C.M.1    Pondé, M.P.2    Freire, A.C.3
  • 40
    • 34247370682 scopus 로고    scopus 로고
    • Risperidone augmentation for treatment-resistant aggression in attention-deficit/hyperactivity disorder: A placebo-controlled pilot study
    • DOI 10.1097/chi.0b013e3180323354, PII 0000458320070500000003
    • Armenteros JL, Lewis JE, Davalos M. Risperidone augmentation for treatmentresistant aggression in attention-deficit/hyperactivity disorder: a placebo-controlled pilot study. J Am Acad Child Adolesc Psychiatry. 2007;46(5):558-565 (Pubitemid 46642572)
    • (2007) Journal of the American Academy of Child and Adolescent Psychiatry , vol.46 , Issue.5 , pp. 558-565
    • Armenteros, J.L.1    Lewis, J.E.2    Davalos, M.3
  • 41
    • 42549085631 scopus 로고    scopus 로고
    • Randomized controlled pilot study of quetiapine in the treatment of adolescent conduct disorder
    • DOI 10.1089/cap.2006.0007
    • Connor DF, McLaughlin TJ, Jeffers-Terry M. Randomized controlled pilot study of quetiapine in the treatment of adolescent conduct disorder. J Child Adolesc Psychopharmacol. 2008;18(2):140-156 (Pubitemid 351591434)
    • (2008) Journal of Child and Adolescent Psychopharmacology , vol.18 , Issue.2 , pp. 140-156
    • Connor, D.F.1    McLaughlin, T.J.2    Jeffers-Terry, M.3
  • 42
    • 57149111476 scopus 로고    scopus 로고
    • Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated children
    • Aman MG, Hollway JA, Leone S, et al. Effects of risperidone on cognitive-motor performance and motor movements in chronically medicated children. Res Dev Disabil. 2009;30(2):386-396
    • (2009) Res Dev Disabil. , vol.30 , Issue.2 , pp. 386-396
    • Aman, M.G.1    Hollway, J.A.2    Leone, S.3
  • 44
    • 0035002882 scopus 로고    scopus 로고
    • A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities
    • Buitelaar JK, van der Gaag RJ, Cohen- Kettenis P, Melman CT. A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. J Clin Psychiatry. 2001;62(4):239-248 (Pubitemid 32428762)
    • (2001) Journal of Clinical Psychiatry , vol.62 , Issue.4 , pp. 239-248
    • Buitelaar, J.K.1    Van Der, G.R.J.2    Cohen-Kettenis, P.3    Melman, C.T.M.4
  • 46
    • 33645905430 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders
    • DOI 10.1176/appi.ajp.163.3.402
    • Reyes M, Buitelaar J, Toren P, Augustyns I, Eerdekens M. A randomized, double-blind, placebo-controlled study of risperidone maintenance treatment in children and adolescents with disruptive behavior disorders. Am J Psychiatry. 2006;163(3):402-410 (Pubitemid 44469381)
    • (2006) American Journal of Psychiatry , vol.163 , Issue.3 , pp. 402-410
    • Reyes, M.1    Buitelaar, J.2    Toren, P.3    Augustyns, I.4    Eerdekens, M.5
  • 48
    • 26844555430 scopus 로고    scopus 로고
    • Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children
    • DOI 10.1016/j.biopsych.2005.03.019, PII S0006322305003598
    • Biederman J, Mick E, Hammerness P, et al. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children. Biol Psychiatry. 2005;58(7):589-594 (Pubitemid 41457306)
    • (2005) Biological Psychiatry , vol.58 , Issue.7 , pp. 589-594
    • Biederman, J.1    Mick, E.2    Hammerness, P.3    Harpold, T.4    Aleardi, M.5    Dougherty, M.6    Wozniak, J.7
  • 49
    • 77949585218 scopus 로고    scopus 로고
    • Comparative openlabel trial of atypical neuroleptics in children and adolescents with bipolar disorder
    • abstract
    • Biederman J, Mick E. Comparative openlabel trial of atypical neuroleptics in children and adolescents with bipolar disorder [abstract]. Eur Neuropsychopharmacol. 2004;14(suppl 3):S211-S212
    • (2004) Eur Neuropsychopharmacol , vol.14 , Issue.SUPPL. 3
    • Biederman, J.1    Mick, E.2
  • 50
    • 67749091140 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder
    • DelBello MP, Chang K, Welge JA, et al. A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. Bipolar Disord. 2009;11(5):483-493
    • (2009) Bipolar Disord , vol.11 , Issue.5 , pp. 483-493
    • DelBello, M.P.1    Chang, K.2    Welge, J.A.3
  • 51
    • 54249083989 scopus 로고    scopus 로고
    • Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder
    • DelBello MP, Versavel M, Ice K, Keller D, Miceli J. Tolerability of oral ziprasidone in children and adolescents with bipolar mania, schizophrenia, or schizoaffective disorder. J Child Adolesc Psychopharmacol. 2008;18(5):491-499
    • (2008) J Child Adolesc Psychopharmacol. , vol.18 , Issue.5 , pp. 491-499
    • DelBello, M.P.1    Versavel, M.2    Ice, K.3    Keller, D.4    Miceli, J.5
  • 53
    • 72849134437 scopus 로고    scopus 로고
    • Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: A randomized, double-blind, placebo-controlled study
    • Findling RL, Nyilas M, Forbes RA, et al. Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2009;70(10):1441-1451
    • (2009) J Clin Psychiatry. , vol.70 , Issue.10 , pp. 1441-1451
    • Findling, R.L.1    Nyilas, M.2    Forbes, R.A.3
  • 54
    • 70350536654 scopus 로고    scopus 로고
    • Risperidone for the treatment of acute mania in children and adolescents with bipolar disorder: A randomized, double-blind, placebo-controlled study
    • Haas M, Delbello MP, Pandina G, et al. Risperidone for the treatment of acute mania in children and adolescents with bipolar disorder: a randomized, double-blind, placebo-controlled study. Bipolar Disord. 2009;11(7):687-700
    • (2009) Bipolar Disord. , vol.11 , Issue.7 , pp. 687-700
    • Haas, M.1    Delbello, M.P.2    Pandina, G.3
  • 55
    • 70350546566 scopus 로고    scopus 로고
    • A 6-week, randomized, double-blind, placebo-controlled study of the efficacy and safety of risperidone in adolescents with schizophrenia
    • Haas M, Unis AS, Armenteros J, Copenhaver MD, Quiroz JA, Kushner SF. A 6-week, randomized, double-blind, placebo-controlled study of the efficacy and safety of risperidone in adolescents with schizophrenia. J Child Adolesc Psychopharmacol. 2009;19(6):611-621
    • (2009) J Child Adolesc Psychopharmacol , vol.19 , Issue.6 , pp. 611-621
    • Haas, M.1    Unis, A.S.2    Armenteros, J.3    Copenhaver, M.D.4    Quiroz, J.A.5    Kushner, S.F.6
  • 56
    • 84857951977 scopus 로고    scopus 로고
    • Four week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of oral ziprasidone in children and adolescents with bipolar I disorder (manic or mixed)
    • NCT00257166
    • NCT00257166. Four week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of oral ziprasidone in children and adolescents with bipolar I disorder (manic or mixed). PhRMA Web Synopsis 2008
    • (2008) PhRMA Web Synopsis
  • 58
    • 67049137947 scopus 로고    scopus 로고
    • Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder: A pilot randomized clinical trial
    • Tramontina S, Zeni CP, Ketzer CR, Pheula GF, Narvaez J, Rohde LA. Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder: a pilot randomized clinical trial. J Clin Psychiatry. 2009;70(5):756-764
    • (2009) J Clin Psychiatry , vol.70 , Issue.5 , pp. 756-764
    • Tramontina, S.1    Zeni, C.P.2    Ketzer, C.R.3    Pheula, G.F.4    Narvaez, J.5    Rohde, L.A.6
  • 59
    • 42049112176 scopus 로고    scopus 로고
    • Rapid increase in rates of bipolar diagnosis in youth: "True" bipolarity or misdiagnosed severe disruptive behavior disorders?
    • DOI 10.1001/archpsyc.65.4.477
    • Holtmann M, Bölte S, Poustka F. Rapid increase in rates of bipolar diagnosis in youth: "true" bipolarity or misdiagnosed severe disruptive behavior disorders? Arch Gen Psychiatry. 2008;65(4):477 (Pubitemid 351519897)
    • (2008) Archives of General Psychiatry , vol.65 , Issue.4 , pp. 477
    • Holtmann, M.1    Bolte, S.2    Poustka, F.3
  • 60
    • 84857939224 scopus 로고    scopus 로고
    • Quetiapine Fumarate (Seroquel) Compared to Placebo in the Treatment of Children & Adolescents with Bipolar I Mania
    • NCT00090311
    • NCT00090311. Quetiapine Fumarate (Seroquel) Compared to Placebo in the Treatment of Children & Adolescents With Bipolar I Mania. Clinical Study Report Synopsis; 2008
    • (2008) Clinical Study Report Synopsis
  • 61
    • 67349114862 scopus 로고    scopus 로고
    • Olanzapine compared to quetiapine in adolescents with a first psychotic episode
    • Arango C, Robles O, Parellada M, et al. Olanzapine compared to quetiapine in adolescents with a first psychotic episode. Eur Child Adolesc Psychiatry. 2009; 18(7):418-428
    • (2009) Eur Child Adolesc Psychiatry. , vol.18 , Issue.7 , pp. 418-428
    • Arango, C.1    Robles, O.2    Parellada, M.3
  • 62
    • 57349148090 scopus 로고    scopus 로고
    • Dosing quetiapine in drug-naive firstepisode psychosis: A controlled, doubleblind, randomized, single-center study investigating efficacy, tolerability, and safety of 200 mg/day vs. 400 mg/day of quetiapine fumarate in 141 patients aged 15 to 25 years
    • Berger GE, Proffitt TM, McConchie M, et al. Dosing quetiapine in drug-naive firstepisode psychosis: a controlled, doubleblind, randomized, single-center study investigating efficacy, tolerability, and safety of 200 mg/day vs. 400 mg/day of quetiapine fumarate in 141 patients aged 15 to 25 years. J Clin Psychiatry. 2008;69(11):1702-1714
    • (2008) J Clin Psychiatry. , vol.69 , Issue.11 , pp. 1702-1714
    • Berger, G.E.1    Proffitt, T.M.2    McConchie, M.3
  • 63
    • 0037313398 scopus 로고    scopus 로고
    • 2 receptor occupancy in patients with recent-onset schizophrenia treated with low-dose olanzapine or haloperidol: A randomized, double-blind study
    • DOI 10.1176/appi.ajp.160.2.303
    • de Haan L, van Bruggen M, Lavalaye J, Booij J, Dingemans PM, Linszen D. Subjective experience and D2 receptor occupancy in patients with recent-onset schizophrenia treated with low-dose olanzapine or haloperidol: a randomized, double-blind study. Am J Psychiatry. 2003;160(2):303-309 (Pubitemid 41110456)
    • (2003) American Journal of Psychiatry , vol.160 , Issue.2 , pp. 303-309
    • De Haan, L.1    Van Bruggen, M.2    Lavalaye, J.3    Booij, J.4    Dingemans, P.M.A.J.5    Linszen, D.6
  • 64
    • 55749106241 scopus 로고    scopus 로고
    • A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia
    • Findling RL, Robb A, Nyilas M, et al. A multiple-center, randomized, double-blind, placebo-controlled study of oral aripiprazole for treatment of adolescents with schizophrenia. Am J Psychiatry. 2008;165(11):1432-1441
    • (2008) Am J Psychiatry , vol.165 , Issue.11 , pp. 1432-1441
    • Findling, R.L.1    Robb, A.2    Nyilas, M.3
  • 65
    • 60149093395 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of two dosing regimens in adolescent schizophrenia: Double-blind study
    • Haas M, Eerdekens M, Kushner S, et al. Efficacy, safety and tolerability of two dosing regimens in adolescent schizophrenia: double-blind study. Br J Psychiatry. 2009;194(2):158-164
    • (2009) Br J Psychiatry , vol.194 , Issue.2 , pp. 158-164
    • Haas, M.1    Eerdekens, M.2    Kushner, S.3
  • 66
    • 50849092550 scopus 로고    scopus 로고
    • A comparative pilot study of secondgeneration antipsychotics in children and adolescents with schizophrenia-spectrum disorders
    • Jensen JB, Kumra S, Leitten W, et al. A comparative pilot study of secondgeneration antipsychotics in children and adolescents with schizophrenia-spectrum disorders. J Child Adolesc Psychopharmacol. 2008;18(4):317-326
    • (2008) J Child Adolesc Psychopharmacol , vol.18 , Issue.4 , pp. 317-326
    • Jensen, J.B.1    Kumra, S.2    Leitten, W.3
  • 67
    • 58249139362 scopus 로고    scopus 로고
    • Olanzapine versus placebo in adolescents with schizophrenia: A 6-week, randomized, double-blind, placebo-controlled trial
    • Kryzhanovskaya L, Schulz SC, McDougle C, et al. Olanzapine versus placebo in adolescents with schizophrenia: a 6-week, randomized, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2009;48(1):60-70
    • (2009) J Am Acad Child Adolesc Psychiatry. , vol.48 , Issue.1 , pp. 60-70
    • Kryzhanovskaya, L.1    Schulz, S.C.2    McDougle, C.3
  • 68
  • 70
    • 33750600803 scopus 로고    scopus 로고
    • An open-label randomized comparison of olanzapine versus risperidone in the treatment of childhood-onset schizophrenia
    • DOI 10.1089/cap.2006.16.393
    • Mozes T, Ebert T, Michal SE, Spivak B, Weizman A. An open-label randomized comparison of olanzapine versus risperidone in the treatment of childhood-onset schizophrenia. J Child Adolesc Psychopharmacol. 2006;16(4):393-403 (Pubitemid 44681460)
    • (2006) Journal of Child and Adolescent Psychopharmacology , vol.16 , Issue.4 , pp. 393-403
    • Mozes, T.1    Ebert, T.2    Michal, S.-E.3    Spivak, B.4    Weizman, A.5
  • 71
    • 84857951967 scopus 로고    scopus 로고
    • A 6-week, international, multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase IIIb study of the efficacy and safety of quetiapine fumarate (Seroquel) immediate- Release tablets in daily doses of 400 mg and 800 mg compared with placebo in the treatment of adolescents with schizophrenia
    • NCT00090324
    • NCT00090324. A 6-week, international, multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase IIIb study of the efficacy and safety of quetiapine fumarate (Seroquel) immediate- release tablets in daily doses of 400 mg and 800 mg compared with placebo in the treatment of adolescents with schizophrenia. Clinical Study Report Synopsis. 2008
    • (2008) Clinical Study Report Synopsis
  • 72
    • 84857937986 scopus 로고    scopus 로고
    • Six week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of oral ziprasidone in adolescent subjects with schizophrenia
    • NCT00257192
    • NCT00257192. Six week, double-blind, placebo controlled phase III trial evaluating the efficacy, safety and pharmacokinetics of flexible doses of oral ziprasidone in adolescent subjects with schizophrenia. PhRMA Web Synopsis. 2010
    • (2010) PhRMA Web Synopsis
  • 74
    • 33745726692 scopus 로고    scopus 로고
    • Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison
    • Shaw P, Sporn A, Gogtay N, et al. Childhood-onset schizophrenia: a double-blind, randomized clozapine-olanzapine comparison. Arch Gen Psychiatry. 2006;63(7):721-730
    • (2006) Arch Gen Psychiatry. , vol.63 , Issue.7 , pp. 721-730
    • Shaw, P.1    Sporn, A.2    Gogtay, N.3
  • 75
    • 55749083565 scopus 로고    scopus 로고
    • Double-blind comparison of first- And second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: Findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study
    • Erratum appears in Am J Psychiatry. 2008 Nov;165(11):1495
    • Sikich L, Frazier JA, McClellan J, et al. Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. [Erratum appears in Am J Psychiatry. 2008 Nov;165(11):1495] Am J Psychiatry. 2008;165(11):1420-1431
    • (2008) Am J Psychiatry , vol.165 , Issue.11 , pp. 1420-1431
    • Sikich, L.1    Frazier, J.A.2    McClellan, J.3
  • 76
    • 0346688561 scopus 로고    scopus 로고
    • A Pilot Study of Risperidone, Olanzapine, and Haloperidol in Psychotic Youth: A Double-Blind, Randomized, 8-Week Trial
    • DOI 10.1038/sj.npp.1300327
    • Sikich L, Hamer RM, Bashford RA, Sheitman BB, Lieberman JA. A pilot study of risperidone, olanzapine, and haloperidol in psychotic youth: a double-blind, randomized, 8-week trial. Neuropsychopharmacology. 2004;29(1):133-145 (Pubitemid 38068023)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.1 , pp. 133-145
    • Sikich, L.1    Hamer, R.M.2    Bashford, R.A.3    Sheitman, B.B.4    Lieberman, J.A.5
  • 77
    • 0028034020 scopus 로고
    • Children with schizophrenia: Diagnosis, phenomenology, and pharmacotherapy
    • Spencer EK, Campbell M. Children with schizophrenia: diagnosis, phenomenology, and pharmacotherapy. Schizophr Bull. 1994;20(4):713-725 (Pubitemid 24373740)
    • (1994) Schizophrenia Bulletin , vol.20 , Issue.4 , pp. 713-725
    • Spencer, E.K.1    Campbell, M.2
  • 78
    • 73449105044 scopus 로고    scopus 로고
    • A trial of quetiapine compared with risperidone in the treatment of first onset psychosis among 15- To 18-year-old adolescents
    • Swadi HS, Craig BJ, Pirwani NZ, Black VC, Buchan JC, Bobier CM. A trial of quetiapine compared with risperidone in the treatment of first onset psychosis among 15- to 18-year-old adolescents. Int Clin Psychopharmacol. 2010;25(1):1-6
    • (2010) Int Clin Psychopharmacol , vol.25 , Issue.1 , pp. 1-6
    • Swadi, H.S.1    Craig, B.J.2    Pirwani, N.Z.3    Black, V.C.4    Buchan, J.C.5    Bobier, C.M.6
  • 79
    • 0842287663 scopus 로고    scopus 로고
    • Symptom response and side-effects of olanzapine and risperidone in young adults with recent onset schizophrenia
    • van Bruggen J, Tijssen J, Dingemans P, Gersons B, Linszen D. Symptom response and side-effects of olanzapine and risperidone in young adults with recent onset schizophrenia. Int Clin Psychopharmacol. 2003;18(6):341-346
    • (2003) Int Clin Psychopharmacol , vol.18 , Issue.6 , pp. 341-346
    • Van Bruggen, J.1    Tijssen, J.2    Dingemans, P.3    Gersons, B.4    Linszen, D.5
  • 80
    • 0142011201 scopus 로고    scopus 로고
    • Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome
    • Erratum appears in Biol Psychiatry. 2003 Aug 15;54(4):497
    • Woods SW, Breier A, Zipursky RB, et al. Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome. [Erratum appears in Biol Psychiatry. 2003 Aug 15;54(4):497] Biol Psychiatry. 2003;54 (4): 453-464
    • (2003) Biol Psychiatry , vol.54 , Issue.4 , pp. 453-464
    • Woods, S.W.1    Breier, A.2    Zipursky, R.B.3
  • 86
    • 0030872372 scopus 로고    scopus 로고
    • Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette's disorder
    • Sallee FR, Nesbitt L, Jackson C, Sine L, Sethuraman G. Relative efficacy of haloperidol and pimozide in children and adolescents with Tourette's disorder. Am J Psychiatry. 1997;154(8):1057-1062 (Pubitemid 27328819)
    • (1997) American Journal of Psychiatry , vol.154 , Issue.8 , pp. 1057-1062
    • Sallee, F.R.1    Nesbitt, L.2    Jackson, C.3    Sine, L.4    Sethuraman, G.5
  • 87
    • 0028335438 scopus 로고
    • Effects of pimozide on cognition in children with Tourette syndrome: Interaction with comorbid attention deficit hyperactivity disorder
    • Sallee FR, Sethuraman G, Rock CM. Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand. 1994;90(1):4-9 (Pubitemid 24212165)
    • (1994) Acta Psychiatrica Scandinavica , vol.90 , Issue.1 , pp. 4-9
    • Sallee, F.R.1    Sethuraman, G.2    Rock, C.M.3
  • 88
    • 0037426394 scopus 로고    scopus 로고
    • A placebo-controlled trial of risperidone in Tourette syndrome
    • Scahill L, Leckman JF, Schultz RT, Katsovich L, Peterson BS. A placebo-controlled trial of risperidone in Tourette syndrome. Neurology. 2003;60(7):1130-1135 (Pubitemid 36418773)
    • (2003) Neurology , vol.60 , Issue.7 , pp. 1130-1135
    • Scahill, L.1    Leckman, J.F.2    Schultz, R.T.3    Katsovich, L.4    Peterson, B.S.5
  • 89
    • 0033541108 scopus 로고    scopus 로고
    • Short-term versus longer term pimozide therapy in Tourette's syndrome: A preliminary study
    • Sehgal N. Short-term versus longer term pimozide therapy in Tourette's syndrome: a preliminary study. Neurology. 1999;52(4):874-877 (Pubitemid 29120205)
    • (1999) Neurology , vol.52 , Issue.4 , pp. 874-877
    • Sehgal, N.1
  • 90
    • 58849123230 scopus 로고    scopus 로고
    • A non-randomized, open study with aripiprazole and ziprasidone for the treatment of aggressive behavior in youth in a community clinic
    • Bastiaens L. A non-randomized, open study with aripiprazole and ziprasidone for the treatment of aggressive behavior in youth in a community clinic. Community Ment Health J. 2009;45(1):73-77
    • (2009) Community Ment Health J , vol.45 , Issue.1 , pp. 73-77
    • Bastiaens, L.1
  • 91
    • 0035068275 scopus 로고    scopus 로고
    • Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: A double-blind, placebo-controlled pilot trial
    • Van Bellinghen M, De Troch C. Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: a double-blind, placebo-controlled pilot trial. J Child Adolesc Psychopharmacol. 2001;11(1):5-13 (Pubitemid 32295178)
    • (2001) Journal of Child and Adolescent Psychopharmacology , vol.11 , Issue.1 , pp. 5-13
    • Van Bellinghen, M.1    De Troch, C.2
  • 93
    • 33846649511 scopus 로고    scopus 로고
    • A naturalistic evaluation of intramuscular ziprasidone versus intramuscular olanzapine for the management of acute agitation and aggression in children and adolescents
    • Khan SS, Mican LM. A naturalistic evaluation of intramuscular ziprasidone versus intramuscular olanzapine for the management of acute agitation and aggression in children and adolescents. J Child Adolesc Psychopharmacol. 2006;16(6):671-677 (Pubitemid 46175423)
    • (2006) Journal of Child and Adolescent Psychopharmacology , vol.16 , Issue.6 , pp. 671-677
    • Khan, S.S.1    Mican, L.M.2
  • 94
    • 71549167580 scopus 로고    scopus 로고
    • Short- And long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents
    • Migliardi G, Spina E, D'Arrigo C, et al. Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33 (8):1496-1501
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry. , vol.33 , Issue.8 , pp. 1496-1501
    • Migliardi, G.1    Spina, E.2    D'Arrigo, C.3
  • 95
    • 0029781286 scopus 로고    scopus 로고
    • Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia
    • Schulz E, Fleischhaker C, Remschmidt HE. Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. J Child Adolesc Psychopharmacol. 1996;6(2):119-131 (Pubitemid 26279068)
    • (1996) Journal of Child and Adolescent Psychopharmacology , vol.6 , Issue.2 , pp. 119-131
    • Schulz, E.1    Fleischhaker, C.2    Remschmidt, H.E.3
  • 98
    • 70349336075 scopus 로고    scopus 로고
    • Weight gain associated with atypical and typical antipsychotics during treatment of adolescent schizophrenic psychoses: A retrospective study
    • Hrdlicka M, Zedkova I, Blatny M, Urbanek T. Weight gain associated with atypical and typical antipsychotics during treatment of adolescent schizophrenic psychoses: a retrospective study. Neuroendocrinol Lett. 2009;30(2):256-261
    • (2009) Neuroendocrinol Lett. , vol.30 , Issue.2 , pp. 256-261
    • Hrdlicka, M.1    Zedkova, I.2    Blatny, M.3    Urbanek, T.4
  • 101
    • 70350738289 scopus 로고    scopus 로고
    • Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents
    • Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK. Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA. 2009;(16): 1765-1773
    • (2009) JAMA , Issue.16 , pp. 1765-1773
    • Correll, C.U.1    Manu, P.2    Olshanskiy, V.3    Napolitano, B.4    Kane, J.M.5    Malhotra, A.K.6
  • 102
    • 35348992825 scopus 로고    scopus 로고
    • Orally disintegrating olanzapine induces less weight gain in adolescents than standard oral tablets
    • DOI 10.1016/j.eurpsy.2007.06.004, PII S0924933807013521
    • Crocq MA, Guillon MS, Bailey PE, Provost D. Orally disintegrating olanzapine induces less weight gain in adolescents than standard oral tablets. Eur Psychiatry. 2007;22(7):453-454 (Pubitemid 47600624)
    • (2007) European Psychiatry , vol.22 , Issue.7 , pp. 453-454
    • Crocq, M.-A.1    Guillon, M.-S.2    Bailey, P.E.3    Provost, D.4
  • 105
    • 0035194171 scopus 로고    scopus 로고
    • Atypical antipsychotic use in treating adolescents and young adults with developmental disabilities
    • Friedlander R, Lazar S, Klancnik J. Atypical antipsychotic use in treating adolescents and young adults with developmental disabilities. Can J Psychiatry. 2001;46(8):741-745
    • (2001) Can J Psychiatry. , vol.46 , Issue.8 , pp. 741-745
    • Friedlander, R.1    Lazar, S.2    Klancnik, J.3
  • 110
    • 80051608049 scopus 로고    scopus 로고
    • CAMESA guideline group. Evidence-based recommendations for monitoring safety of second generation antipsychotics in children and youth
    • Pringsheim T, Panagiotopoulos C, Davidson J, Ho J; CAMESA guideline group. Evidence-based recommendations for monitoring safety of second generation antipsychotics in children and youth. J Can Acad Child Adolesc Psychiatry. 2011;20(3):218-233
    • (2011) J Can Acad Child Adolesc Psychiatry. , vol.20 , Issue.3 , pp. 218-233
    • Pringsheim, T.1    Panagiotopoulos, C.2    Davidson, J.3    Ho, J.4
  • 111
    • 84857951978 scopus 로고    scopus 로고
    • Available at: Accessed September 19, 2011
    • Kompetenznetz Therapeutisches Drug Monitoring. Kinder- und Jugendpsychiatrie e.v. Available at: http://tdm-kjp.com/. Accessed September 19, 2011
    • Kompetenznetz Therapeutisches Drug Monitoring


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