Identification of a Novel Cell-Penetrating Peptide from Human Phosphatidate Phosphatase LpIN3

Molecules and Cells

Volumn 34, Issue 6, 2012, Pages 577-582

  Lim, Sangho ^a   Kim, Won ju ^a   Kim, Yeon ho ^a   Choi, Je Min ^a  

^a Hanyang University   (South Korea)

Author keywords

CPP; drug delivery system; LPIN; PTD

Indexed keywords

CELL PENETRATING PEPTIDE; LPIN3 PROTEIN, HUMAN; PHOSPHATIDATE PHOSPHATASE;

ANIMAL; ARTICLE; CELL MEMBRANE; CHEMISTRY; GENETICS; HELA CELL; HUMAN; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; MOUSE;

ANIMALS; CELL MEMBRANE; CELL-PENETRATING PEPTIDES; HELA CELLS; HUMANS; JURKAT CELLS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHATIDATE PHOSPHATASE;

EID: 84880060102     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-012-0284-y     Document Type: Article

References (30)

1. Choi, J.M., Ahn, M.H., Chae, W.J., Jung, Y.G., Park, J.C., Song, H.M., Kim, Y.E., Shin, J.A., Park, C.S., Park, J.W., Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat. Med 12 (2006), 574–579 et al.
2. Choi, J.M., Kim, S.H., Shin, J.H., Gibson, T., Yoon, B.S., Lee, D.H., Lee, S.K., Bothwell, A.L., Lim, J.S., Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis. Proc. Natl. Acad. Sci. USA 105 (2008), 19875–19880.
3. Choi, J.M., Shin, J.H., Sohn, M.H., Harding, M.J., Park, J.H., Tobiasova, Z., Kim, D.Y., Maher, S.E., Chae, W.J., Park, S.H., Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation. Proc. Natl. Acad. Sci. USA 107 (2010), 18575–18580 et al.
4. Choi, J.M., Sohn, J.H., Park, T.Y., Park, J.W., Lee, S.K., Cell permeable NFAT inhibitory peptide Sim-2-VIVIT inhibits T-cell activation and alleviates allergic airway inflammation and hyper-responsiveness. Immunol. Lett 143 (2012), 170–176.
5. De Coupade, C., Fittipaldi, A., Chagnas, V., Michel, M., Carlier, S., Tasciotti, E., Darmon, A., Ravel, D., Kearsey, J., Giacca, M., Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules. Biochem. J 390 (2005), 407–418 et al.
6. Derossi, D., Joliot, A.H., Chassaing, G., Prochiantz, A., The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem 269 (1994), 10444–10450.
7. Deshayes, S., Morris, M.C., Divita, G., Heitz, F., Cellpenetrating peptides: tools for intracellular delivery of therapeutics. Cell Mol. Life Sci 62 (2005), 1839–1849.
8. Donkor, J., Sariahmetoglu, M., Dewald, J., Brindley, D.N., Reue, K., Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J. Biol. Chem 282 (2007), 3450–3457.
9. Duchardt, F., Ruttekolk, I.R., Verdurmen, W.P., Lortat-Jacob, H., Burck, J., Hufnagel, H., Fischer, R., van den Heuvel, M., Lowik, D.W., Vuister, G.W., A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J. Biol. Chem 284 (2009), 36099–36108 et al.
10. Eguchi, A., Meade, B.R., Chang, Y.C., Fredrickson, C.T., Willert, K., Puri, N., Dowdy, S.F., Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat. Biotechnol 27 (2009), 567–571.
11. Elliott, G., O'Hare, P., Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88 (1997), 223–233.
12. Fischer, R., Kohler, K., Fotin-Mleczek, M., Brock, R., A stepwise dissection of the intracellular fate of cationic cellpenetrating peptides. J. Biol. Chem 279 (2004), 12625–12635.
13. Frankel, A.D., Pabo, C.O., Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55 (1988), 1189–1193.
14. Heitz, F., Morris, M.C., Divita, G., Twenty years of cellpenetrating peptides: from molecular mechanisms to therapeutics. Br. J. Pharmacol 157 (2009), 195–206.
15. Hotchkiss, R.S., McConnell, K.W., Bullok, K., Davis, C.G., Chang, K.C., Schwulst, S.J., Dunne, J.C., Dietz, G.P., Bahr, M., McDunn, J.E., TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J. Immunol 176 (2006), 5471–5477 et al.
16. Martin, M.E., Rice, K.G., Peptide-guided gene delivery. AAPS J 9 (2007), E18–E29.
17. Morris, M.C., Depollier, J., Mery, J., Heitz, F., Divita, G., A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat. Biotechnol 19 (2001), 1173–1176.
18. Noguchi, H., Matsushita, M., Okitsu, T., Moriwaki, A., Tomizawa, K., Kang, S., Li, S.T., Kobayashi, N., Matsumoto, S., Tanaka, K., A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat. Med 10 (2004), 305–309 et al.
19. Ogris, M., Wagner, E., Targeting tumors with non-viral gene delivery systems. Drug Discov. Today 7 (2002), 479–485.
20. Reue, K., Brindley, D.N., Thematic review series: glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. J. Lipid Res 49 (2008), 2493–2503.
21. Richard, J.P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M.J., Chernomordik, L.V., Lebleu, B., Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem 278 (2003), 585–590.
22. Rittner, K., Benavente, A., Bompard-Sorlet, A., Heitz, F., Divita, G., Brasseur, R., Jacobs, E., New basic membranedestabilizing peptides for plasmid-based gene delivery in vitro and in vivo. Mol. Ther 5 (2002), 104–114.
23. Schwarze, S.R., Ho, A., Vocero-Akbani, A., Dowdy, S.F., In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999), 1569–1572.
24. Snyder, E.L., Dowdy, S.F., Cell penetrating peptides in drug delivery. Pharm. Res 21 (2004), 389–393.
25. Torchilin, V.P., Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug. Discov 4 (2005), 145–160.
26. Valdearcos, M., Esquinas, E., Meana, C., Gil-de-Gomez, L., Guijas, C., Balsinde, J., Balboa, M.A., Subcellular localiza-tion and role of lipin-1 in human macrophages. J. Immunol 186 (2011), 6004–6013.
27. van den Berg, A., Dowdy, S.F., Protein transduction domain delivery of therapeutic macromolecules. Curr. Opin. Biotechnol 22 (2011), 888–893.
28. Wadia, J.S., Stan, R.V., Dowdy, S.F., Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat. Med 10 (2004), 310–315.
29. Zhao, J., Gao, P., Xiao, W., Fan, L.Q., Wang, F.J., Li, S.X., Liu, J.W., A novel human derived cell-penetrating peptide in drug delivery. Mol. Biol. Rep 38 (2011), 2649–2656.
30. Zorko, M., Langel, U., Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Adv. Drug Deliv. Rev 57 (2005), 529–545.