A novel process for erythromycin separation from fermentation broth by resin adsorption-aqueous crystallization

Separation and Purification Technology

Volumn 116, Issue , 2013, Pages 398-404

  Zheng, Wenjian ^a   Chen, Kui ^a   Zhu, Jiawen ^a   Ji, Lijun ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Aqueous crystallization; Erythromycin separation; Fixed bed adsorption

Indexed keywords

ADSORPTION RATES; BREAK THROUGH CURVE; EFFECTIVE REMOVALS; EXPERIMENTAL DATUM; FERMENTATION BROTHS; FIXED-BED ADSORPTION; MACROPOROUS RESIN; RATE-LIMITING STEPS;

ANTIBIOTICS; FERMENTATION; REACTION KINETICS; RESINS; SEPARATION;

ADSORPTION;

EID: 84880049718     PISSN: 13835866     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seppur.2013.06.019     Document Type: Article

References (17)

1. Y.S. He, G. Chen, Z.J. Ji, and S.X. Li Combined UF-NF membrane system for filtering erythromycin fermentation broth and concentrating the filtrate to improve the downstream efficiency Sep. Purif. Technol. 66 2009 390 396
2. S.Z. Li, X.Y. Li, Z.F. Cui, and D.Z. Wang Application of ultrafiltration to improve the extraction of antibiotics Sep. Purif. Technol. 34 2004 115 123 (Pubitemid 38135544)
3. Z. Li, F. Qin, H. Bao, and X.Q. Gu Study on new solvent extraction systems for erythromycin J. Chem. Technol. Biotechnol. 80 2005 772 781 (Pubitemid 40903208)
4. C. Dan, and G. Anca-Irina New extraction techniques on bioseparations: 1. Reactive extraction Hem. Ind. 58 2004 375 386
5. J. Kawasakia, R. Egashiraa, T. Kawaia, H. Haraa, and L. Boyadzhiev Recovery of erythromycin by a liquid membrane J. Memb. Sci. 112 1995 209 217 (Pubitemid 26123396)
6. G.J. Lye, and D.C. Stuckey Extraction of erythromycin-A using colloidal liquid aphrons: I. Equilibrium partitioning J. Chem. Technol. Biotechnol. 75 2000 339 347 (Pubitemid 30223792)
7. Q.H. Le, L.L. Shong, and Y.H. Shi Extraction of erythromycin from fermentation broth using salt-induced phase separation processes Sep. Purif. Technol. 24 2000 85 91
8. Y.H. Song, J.W. Zhu, K. Chen, L. Liang, and Y. Sun Adsorption kinetics of erythromycin on macroporous resins Ion Exch. Adsorp. 23 2007 349 359 (Pubitemid 47306797)
9. M.H.L. Ribeiro, and I.A.C. Ribeiro Recovery of erythromycin from fermentation broth by adsorption onto neutral and ion-exchange resins Sep. Purif. Technol. 45 2005 232 239 (Pubitemid 41475616)
10. Y. Sun, J.W. Zhu, K. Chen, and J. Xu Modeling erythromycin adsorption to the macroporous resin sepabead Sp825 Chem. Eng. Commun. 196 2009 906 916
11. A.J. Booth, S.H. Ngiam, and G.J. Lye Antibiotic purification from fermentation broths by counter-current chromatography Analysis 2004 51 61
12. A.J. Booth, I.A. Sutherland, and G.J. Lye Modeling the performance of pilot-scale countercurrent chromatography: scale-up predictions and experimental verification of erythromycin separation Biotechnol. Bioenergy 81 2003 640 649 (Pubitemid 36258517)
13. S. Zhu, J.W. Zhu, and K. Chen Effect of pH and ionic strength on competitive adsorption of erythromycin a and C onto macroporous resin sepabead Sp825 at different temperatures Chem. Eng. Commun. 198 2011 1206 1217
14. N.D. Danielson, J.A. Holeman, D.C. Bristol, and D.H. Kirzner Simple methods for the qualitative indentification and quantitative determination of macrolide antibiotics J. Pharm. Biomed. Anal. 11 1993 121 130 (Pubitemid 23152290)
15. X.L. Du, Q.P. Yuan, and Y. Li Equilibrium, thermodynamics and breakthrough studies for adsorption of solanesol onto macroporous resins Chem. Eng. Process. 47 2008 1420 1427
16. Y. Sun, J.W. Zhu, K. Chen, S. zhu, and J. Xu Mass transfer mechanisms in fixed-bed adsorption of erythromycin Front. Chem. Eng. China 2 2008 353 360
17. Y.H. Kim, T.M. Heinze, R. Beger, J.V. Pothuluri, and C.E. Cerniglia A kinetic study on the degradation of erythromycin a in aqueous solution Int. J. Pharm. 271 2004 63 76 (Pubitemid 38210085)