Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells

Biochemical and Biophysical Research Communications

Volumn 436, Issue 4, 2013, Pages 660-665

  Han, Seong Su ^a   Tompkins, Van S ^a   Son, Dong Ju ^b   Kamberos, Natalie L ^a   Stunz, Laura L ^a,c   Halwani, Ahmad ^a   Bishop, Gail A ^a,c,d   Janz, Siegfried ^a  

^a UNIVERSITY OF IOWA   (United States)

^b Emory University   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

BL; Cancer therapy and prevention; Epstein Barr virus; NF B; P21 Encoding Cdkn1a; PL; Transgenic mouse model of human endemic Burkitt lymphoma

Indexed keywords

ANTINEOPLASTIC AGENT; AURORA A KINASE; BCAT1 PROTEIN; BUB1B PROTEIN; CCNB1 PROTEIN; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; FANCONI ANEMIA GROUP D2 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LMP1 PROTEIN; MESSENGER RNA; MYC PROTEIN; PIPERLONGUMINE; PROTEIN; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; XRCC6 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; DOWN REGULATION; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BL; BURKITT LYMPHOMA; CANCER THERAPY AND PREVENTION; EPSTEIN BARR VIRUS; NF-ΚB; P21-ENCODING CDKN1A; PIPERLONGUMINE; PL; TRANSGENIC MOUSE MODEL OF HUMAN ENDEMIC BURKITT LYMPHOMA;

ANIMALS; CELL LINE, TUMOR; DIOXOLANES; GENES, MYC; LYMPHOMA, B-CELL; MICE; MICE, INBRED C57BL; NF-KAPPA B; VIRAL MATRIX PROTEINS;

HUMAN HERPESVIRUS 4; MUS MUSCULUS; PIPER LONGUM;

EID: 84880040845     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.012     Document Type: Article

References (36)

1. Singh N., Kumar S., Singh P., Raj H.G., Prasad A.K., Parmar V.S., Ghosh B. Piper longum Linn. extract inhibits TNF-α-induced expression of cell adhesion molecules by inhibiting NF-κB activation and microsomal lipid peroxidation. Phytomedicine 2008, 15:284-291.
2. Han S.-S., Son D.-J., Yun H., Kamberos N.L., Janz S. Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. Leuk. Res. 2013, 37:146-154.
3. Raj L., Ide T., Gurkar A.U., Foley M., Schenone M., Li X., Tolliday N.J., Golub T.R., Carr S.A., Shamji A.F., Stern A.M., Mandinova A., Schreiber S.L., Lee S.W. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 2011, 475:231-234.
4. Wang D., Liebowitz D., Kieff E. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 1985, 43:831-840.
5. Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R.C., Croce C.M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc. Natl. Acad. Sci. 1982, 79:7824-7827.
6. Saha A., Robertson E.S. Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes. Clin. Cancer Res. 2011, 17:3056-3063.
7. Levens D.L. Reconstructing myc. Genes Dev. 2003, 17:1071-1077.
8. Li Q., Verma I.M. NF-[kappa] B regulation in the immune system. Nat. Rev. Immunol. 2002, 2:725-734.
9. Squarize C.H., Castilho R.M., Sriuranpong V., Pinto D.S., Gutkind J.S. Molecular cross-talk between the NF kappa B and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia 2006, 8:733-746.
10. Espinosa I., Briones J., Bordes R., Brunet S., Martino R., Sureda A., Sierra J., Prat J. Activation of the NF-κB signalling pathway in diffuse large B-cell lymphoma: clinical implications. Histopathology 2008, 53:441-449.
11. Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006, 441:431-436.
12. Shair K.H.Y., Bendt K.M., Edwards R.H., Bedford E.C., Nielsen J.N., Raab-Traub N. EBV latent membrane protein 1 activates Akt, NFκB, and Stat3 in B cell lymphomas. PLoS Pathog. 2007, 3:e166.
13. Lee H., Arsura M., Wu M., Duyao M., Buckler A.J., Sonenshein G.E. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J. Exp. Med. 1995, 181:1169-1177.
14. Wu M., Arsura M., Bellas R.E., FitzGerald M.J., Lee H., Schauer S.L., Sherr D.H., Sonenshein G.E. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Mol. Cell. Biol. 1996, 16:5015-5025.
15. Faumont N., Durand-Panteix S., Schlee M., Grömminger S., Schuhmacher M., Hölzel M., Laux G., Mailhammer R., Rosenwald A., Staudt L.M., Bornkamm G.W., Feuillard J. c-Myc and Rel/NF-κB are the two mMaster transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells. J. Virol. 2009, 83:5014-5027.
16. Park S.S., Kim J.S., Tessarollo L., Owens J.D., Peng L., Han S.S., Tae Chung S., Torrey T.A., Cheung W.C., Polakiewicz R.D., McNeil N., Ried T., Mushinski J.F., Morse H.C., Janz S. Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res. 2005, 65:1306-1315.
17. Stunz L.L., Busch L.K., Munroe M.E., Sigmund C.D., Tygrett L.T., Waldschmidt T.J., Bishop G.A. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity 2004, 21:255-266.
18. Su Han S., Shaffer A., Peng L., Chung S., Lim J., Maeng S., Su Kim J., McNeil N., Ried T., Staudt L., Janz S. Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1. Mol. Cancer 2005, 4:40.
19. Bren G.D., Solan N.J., Miyoshi H., Pennington K.N., Pobst L.J., Paya C.V. Transcription of the RelB gene is regulated by NF-kappaB. Oncogene 2001, 20:7722.
20. den Hollander J., Rimpi S., Doherty J.R., Rudelius M., Buck A., Hoellein A., Kremer M., Graf N., Scheerer M., Hall M.A. Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood 2010, 116:1498-1505.
21. Yoshikawa R., Yanagi H., Shen C.-S., Fujiwara Y., Noda M., Yagyu T., Gega M., Oshima T., Yamamura T., Okamura H. ECA39 is a novel distant metastasis-related biomarker in colorectal cancer. World J. Gastroenterol. 2006, 12:5884.
22. Dai Y., Tang Y., He F., Zhang Y., Cheng A., Gan R., Wu Y. Screening and functional analysis of differentially expressed genes in EBV-transformed lymphoblasts. Virol. J. 2012, 9:1-9.
23. Wang W.-J., Wu S.-P., Liu J.-B., Shi Y.-S., Huang X., Zhang Q.-B., Yao K.-T. MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells. Cancer Res. 2013, 73:1219-1231.
24. O'Donnell K.A., Yu D., Zeller K.I. Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol. Cell. Biol. 2006, 26:2373-2386.
25. Liang Y., Liu M., Wang P., Ding X., Cao Y. Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer. Genes Chromosomes Cancer 2013, 52:305-315.
26. Wang S.M., Ooi L.L.P., Hui K.M. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin. Cancer Res. 2011, 17:6040-6051.
27. Pliarchopoulou K., Kalogeras K., Kronenwett R., Wirtz R., Eleftheraki A., Batistatou A., Bobos M., Soupos N., Polychronidou G., Gogas H. Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial. Cancer Chemother. Pharmacol. 2013, 71:245-255.
28. Mishima M., Kaitna S., Glotzer M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2002, 2:41-54.
29. Tonozuka Y., Minoshima Y., Bao Y.C., Moon Y., Tsubono Y., Hatori T., Nakajima H., Nosaka T., Kawashima T., Kitamura T. A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. Blood 2004, 104:3550-3557.
30. Hordijk P.L. Regulation of NADPH oxidases: the role of Rac proteins. Circ. Res. 2006, 98:453-462.
31. Viale A., De Franco F., Orleth A., Cambiaghi V., Giuliani V., Bossi D., Ronchini C., Ronzoni S., Muradore I., Monestiroli S. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 2009, 457:51-56.
32. Abbas T., Dutta A. P21 in cancer: intricate networks and multiple activities. Nat. Rev. Cancer 2009, 9:400-414.
33. Basile J.R., Eichten A., Zacny V., Münger K. NF-κB-mediated induction of p21Cip1/Waf1 by tumor necrosis factor α induces growth arrest and cytoprotection in normal human keratinocytes1 1 R01 CA81135 (K.M.), K16DE00275 (J.R.B.), DAAD Doktorandenstipendium im Rahmen des gemeinsamen HSP III von Bund und Ländern (A.E.) and a Senior Postdoctoral Fellowship from the New England Division of the American Cancer Society (V.Z.). Mol. Cancer Res. 2003, 1:262-270.
34. Lim J.W., Kim H., Kim K.H. Expression of Ku70 and Ku80 mediated by NF-κB and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. J. Biol. Chem. 2002, 277:46093-46100.
35. Yarde D.N., Oliveira V., Mathews L., Wang X., Villagra A., Boulware D., Shain K.H., Hazlehurst L.A., Alsina M., Chen D.-T. Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 2009, 69:9367-9375.
36. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.