Heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from radiation therapy-induced intestinal injury

Journal of Pediatric Surgery

Volumn 48, Issue 6, 2013, Pages 1316-1322

  Matthews, Mika A B ^a,b   Watkins, Daniel ^a,b   Darbyshire, Amanda ^a,b   Carson, William E ^a,b   Besner, Gail E ^a,b  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

HB EGF; Intestines; Permeability; Proliferation; Radiation injury

Indexed keywords

BROXURIDINE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WHOLE BODY RADIATION;

HB-EGF; INTESTINES; PERMEABILITY; PROLIFERATION; RADIATION INJURY;

ANIMALS; CELL PROLIFERATION; FEMALE; GASTROINTESTINAL AGENTS; INJECTIONS, INTRAPERITONEAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; MICE; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RANDOM ALLOCATION; TREATMENT OUTCOME;

EID: 84880011129     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2013.03.030     Document Type: Conference Paper

References (21)

1. M. Hauer-Jensen, J. Wang, and J.W. Denham Bowel injury: current and evolving management strategies Semin Radiat Oncol 13 2003 357 371
2. M.M. Bismar, and F.A. Sinicrope Radiation enteritis Curr Gastroenterol Rep 4 2002 361 365
3. G. Besner, S. Higashiyama, and M. Klagsbrun Isolation and characterization of a macrophage-derived heparin-binding growth factor Cell Regul 1 1990 811 819
4. V.B. Mehta, Y. Zhou, and A. Radulescu HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis Growth Factors 26 2008 301 315
5. K.M. Davis-Fleischer, and G.E. Besner Structure and function of heparin-binding EGF-like growth factor (HB-EGF) Front Biosci 3 1998 d288 d299
6. D.V. Rocourt, V.B. Mehta, and G.E. Besner Heparin-binding EGF-like growth factor decreases inflammatory cytokine expression after intestinal ischemia/reperfusion injury J Surg Res 139 2007 269 273
7. J. Feng, and G.E. Besner Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis J Pediatr Surg 42 2007 214 220
8. M.A. Kuhn, G. Xia, and V.B. Mehta Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo Antioxid Redox Signal 4 2002 639 646
9. I.A. James, C.L. Chen, and G. Huang HB-EGF protects the lungs after intestinal ischemia/reperfusion injury J Surg Res 163 2010 86 95
10. A. Radulescu, N.A. Zorko, and X. Yu Preclinical neonatal rat studies of heparin-binding EGF-like growth factor in protection of the intestines from necrotizing enterocolitis Pediatr Res 65 2009 437 442
11. S.B. Pillai, C.E. Hinman, and M.H. Luquette Heparin-binding epidermal growth factor-like growth factor protects rat intestine from ischemia/reperfusion injury J Surg Res 87 1999 225 231
12. H.Y. Zhang, A. Radulescu, and C.L. Chen Mice overexpressing the gene for heparin-binding epidermal growth factor-like growth factor (HB-EGF) have increased resistance to hemorrhagic shock and resuscitation Surgery 149 2011 276 283
13. C.W. Langberg, T. Sauer, and J.B. Reitan Tolerance of rat small intestine to localized single dose and fractionated irradiation Acta Oncol 31 1992 781 787
14. S.R. Oliver, N.A. Phillips, and V.L. Novosad Hyperthermia induces injury to the intestinal mucosa in the mouse: evidence for an oxidative stress mechanism Am J Physiol Regul Integr Comp Physiol 302 2012 R845 R853
15. Q. Wang, C.H. Fang, and P.O. Hasselgren Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice Am J Physiol Regul Integr Comp Physiol 281 2001 R1013 R1023
16. G. Xia, A.E. Martin, and M.P. Michalsky Heparin-binding EGF-like growth factor preserves crypt cell proliferation and decreases bacterial translocation after intestinal ischemia/reperfusion injury J Pediatr Surg 37 2002 1081 1087 [discussion 1081-1087]
17. J. Feng, V.B. Mehta, and O.N. El-Assal Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats Peptides 27 2006 1589 1596
18. C.L. Farrell, J.V. Bready, and K.L. Rex Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality Cancer Res 58 1998 933 939
19. H. Oh, J. Seong, and W. Kim Recombinant human epidermal growth factor (rhEGF) protects radiation-induced intestine injury in murine system J Radiat Res 51 2010 535 541
20. P. Bhanja, S. Saha, and R. Kabarriti Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice PLoS One 4 2009 e8014
21. F. Nakayama, A. Hagiwara, and S. Umeda Post treatment with an FGF chimeric growth factor enhances epithelial cell proliferation to improve recovery from radiation-induced intestinal damage Int J Radiat Oncol Biol Phys 78 2010 860 867