Tumorigenic potential of mir-18a in Glioma initiating cells requires notch-1 signaling

Stem Cells

Volumn 31, Issue 7, 2013, Pages 1252-1265

  Turchi, Laurent ^a,b   Debruyne, David N ^a,b   Almairac, Fabien ^a,b,c   Virolle, Virginie ^a,b   Fareh, Mohamed ^a,b   Neirijnck, Yasmine ^a,b   Burel Vandenbos, Fanny ^a,b,d   Paquis, Philippe ^a,b,c   Junier, Marie Pierre ^b   Obberghen Schilling, Ellen Van ^a,b   Chneiweiss, Hervé ^b   Virolle, Thierry ^a,b  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b INSERM   (France)

^c Service de Neurochirurgie   (France)

^d PASTEUR HOSPITAL   (France)

Author keywords

Delta like 3 protein; Extracellular signal regulated kinase; Glioblastoma; miR 18a; NOTCH; Sonic hedgehog

Indexed keywords

MICRORNA; MICRORNA 18A; NOTCH1 RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; GLIOMA CELL; GLIOMA INITIATING CELL; HUMAN; HUMAN CELL; MALE; PLASTICITY; STEM CELL;

DELTA LIKE 3 PROTEIN; EXTRACELLULAR SIGNAL-REGULATED KINASE; GLIOBLASTOMA; MIR-18A*; NOTCH; SONIC HEDGEHOG;

AGED; ANIMALS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; DOWN-REGULATION; GLIOMA; HEDGEHOG PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; MICRORNAS; MIDDLE AGED; RECEPTOR, NOTCH1; TRANSFECTION;

ERINACEIDAE;

EID: 84879987701     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1373     Document Type: Article

References (33)

1. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-768.
2. Murat A, Migliavacca E, Gorlia T et al. Stem cell-related ''selfrenewal'' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol 2008;26:3015-3024.
3. Stupp R, Hegi ME. Targeting brain-tumor stem cells. Nat Biotechnol 2007;25:193-194.
4. Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004;5:738-743.
5. Ponti D, Costa A, Zaffaroni N et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65:5506-5511.
6. Schatton T, Murphy GF, Frank NY et al. Identification of cells initiating human melanomas. Nature 2008;451:345-349.
7. Galli R, Binda E, Orfanelli U et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-7021.
8. Chen R, Nishimura MC, Bumbaca SM et al. A hierarchy of selfrenewing tumor-initiating cell types in glioblastoma. Cancer Cell 2010;17:362-375.
9. Prestegarden L, Svendsen A, Wang J et al. Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res 2010;70:4274-4279.
10. Ogden AT, Waziri AE, Lochhead RA et al. Identification of A2B5+CD133 tumor-initiating cells in adult human gliomas. Neurosurgery 2008;62:505-514, discussion 514-505.
11. Wang J, Sakariassen PO, Tsinkalovsky O et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 2008;122:761-768.
12. Fan X, Khaki L, Zhu TS et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 2010;28:5-16.
13. Karsy M, Albert L, Tobias ME et al. All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner. Anticancer Res 2010;30:4915-4920.
14. Clement V, Sanchez P, de Tribolet N et al. HEDGEHOG-GLI-1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 2007;17:165-172.
15. Zbinden M, Duquet A, Lorente-Trigos A et al. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI-1 and p53.EMBO J 2010;29:2659-74.
16. Fareh M, Turchi L, Virolle V et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ 2012;19: 232-244.
17. Patru C, Romao L, Varlet P et al. CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of longterm cultured cancer Stem Cells from human malignant glio-neuronal tumors. Bmc Cancer 2010;10:66.
18. Verhaak RG, Hoadley KA, Purdom E et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, And NF1.Cancer Cell 2010;17:98-110.
19. Paroo Z, Ye X, Chen S et al. Phosphorylation of the human micro- RNA-generating complex mediates MAPK/Erk signaling. Cell 2009; 139:112-122.
20. Lefloch R, Pouyssegur J, Lenormand P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol 2008; 28:511-527.
21. Seto M, Ohta M, Asaoka Y et al. Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. Mol Carcinog 2009;48:703-712.
22. Chapman G, Sparrow DB, Kremmer E et al. Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. Hum Mol Genet 2011;20:905-916.
23. Hoyne GF, Chapman G, Sontani Y et al. A cell autonomous role for the Notch ligand Delta-like 3 in alphabeta T-cell development. Immunol Cell Biol 2011;89:696-705.
24. Alcock J, Sottile V. Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex. Cell Res 2009;19: 1324-1333.
25. Elkouris M, Balaskas N, Poulou M et al. Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1- mediated cell cycle exit and neurogenesis. Stem Cells 2011;29:89-98.
26. Salcido CD, Larochelle A, Taylor BJ et al. Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br J Cancer 2010;102:1636-1644.
27. Ying QL, Wray J, Nichols J et al. The ground state of embryonic stem cell self-renewal. Nature 2008;453:519-523.
28. Lluis F, Cosma MP. Somatic cell reprogramming control: Signaling pathway modulation versus transcription factor activities. Cell Cycle 2009;8:1138-1144.
29. Lee JA, Jang DJ, Kaang BK. Two major gate-keepers in the selfrenewal of neural stem cells: Erk1/2 and PLCgamma1 in FGFR signaling. Mol Brain 2009;2:15
30. Ma DK, Ponnusamy K, Song MR et al. Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. Mol Brain 2009; 2:16.
31. Takakura S, Mitsutake N, Nakashima M et al. Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Sci 2008; 99:1147-1154.
32. Tsang WP, Kwok TT. The miR-18a microRNA functions as a potential tumor suppressor by targeting on K-Ras. Carcinogenesis 2009;30: 953-959.
33. Liu ZJ, Xiao M, Balint K et al. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/ phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Research 2006;66:4182-4190.