Of mice and men: What rodent models don't tell us

Cellular and Molecular Immunology

Volumn 10, Issue 4, 2013, Pages 284-285

  Drake, Adam C ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; TOLL LIKE RECEPTOR;

ARTICLE; AUTOIMMUNITY; CHRONIC INFLAMMATION; DISEASE MODEL; ENDOTOXEMIA; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL MOUSE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IMMUNE RESPONSE; INFLAMMATORY DISEASE; MEDICAL RESEARCH; NONHUMAN; PUBLICATION; SPECIES COMPARISON; TOXIN ANALYSIS; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; FEMALE; GENOMICS; HUMANS; INFLAMMATION; MALE;

MUS; RODENTIA;

EID: 84879983546     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.21     Document Type: Article

References (7)

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2. van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V et al. Can animal models of disease reliably inform human studies? PLo S Med 2010; 7: e 1000245.
3. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P et al. Initial sequencing and comparative analysis of the mouse genome. Nature 2002; 420: 520-562. (Pubitemid 35477048)
4. Wiersinga WJ. Current insights in sepsis: from pathogenesis to new treatment targets. Curr Opin Crit Care 2011; 17: 480-486.
5. Mitka M. Drugforseveresepsisiswithdrawn from market, failsto reduce mortality. JAMA 2011; 306: 2439-2440.
6. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL. Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol 2012; 12: 786-798.
7. Drake AC, Chen Q, Chen J. Engineering humanized mice for improved hematopoietic reconstitution. Cell Mol Immunol 2012; 9: 215-224.