Trpm8 agonists modulate contraction of the pig urinary bladder

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 7, 2013, Pages 503-509

  Vahabi, Bahareh ^a,b   Parsons, Brian A ^b   Doran, Olena ^a   Rhodes, Anthony ^a   Dean, Sarah ^a   Drake, Marcus J ^b,c  

^a UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Detrusor; Icilin; Isolated bladder; Menthol; Pig; TRPM8; Urothelium

Indexed keywords

CARBACHOL; MENTHOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8;

ARTICLE; BLADDER CONTRACTION; BLADDER PRESSURE; CONTROLLED STUDY; DETRUSOR MUSCLE; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; OVERACTIVE BLADDER; PRIORITY JOURNAL; SWINE; UROTHELIUM;

ANIMALS; FEMALE; MENTHOL; MUSCLE CONTRACTION; PYRIMIDINONES; SWINE; TRPM CATION CHANNELS; URINARY BLADDER; UROTHELIUM;

EID: 84879980095     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0406     Document Type: Article

References (21)

1. Andersson, K.E., Gratzke, C., and Hedlund, P. 2010. The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder. BJU Int. 106: 1114-1127. doi:10.1111/j.1464-410X.2010.09650.x. PMID:21156013.
2. Baylie, R.L., Cheng, H., Langton, P.D., and James, A.F. 2010. Inhibition of the cardiac L-type calcium channel current by the TRPM8 agonist, (-)-menthol. J. Physiol. Pharmacol. 61: 543-550. PMID:21081797.
3. Behrendt, H.J., Germann, T., Gillen, C., Hatt, H., and Jostock, R. 2004. Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br. J. Pharmacol. 141: 737-745. doi:10.1038/sj.bjp.0705652. PMID:14757700.
4. Birder, L.A. 2011. Urothelial signaling. Handb. Exp. Pharmacol. 202: 207-231. doi:10.1007/978-3-642-16499-6_10. PMID:21290228.
5. Birder, L.A., Kanai, A.J., de Groat, W.C., Kiss, S., Nealen, M.L., Burke, N.E., Dineley, K.E., Watkins, S., Reynolds, I.J., and Caterina, M.J. 2001. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 98: 13396-13401. doi:10.1073/pnas. 231243698. PMID:11606761.
6. Birder, L.A., Kanai, A.J., Cruz, F., Moore, K., and Fry, C.H. 2010. Is the urothelium intelligent? Neurourol. Urodyn. 29: 598-602. doi:10.1002/nau.20914. PMID: 20432319.
7. Bors, E.H., and Blinn, K.A. 1957. Spinal reflex activity from the vesical mucosa in paraplegic patients. AMA Arch. Neurol. Psychiatry, 78: 339-354. doi:10.1001/ archneurpsyc.1957.02330400013002. PMID:13457509.
8. Du, S., Araki, I., Kobayashi, H., Zakoji, H., Sawada, N., and Takeda, M. 2008. Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs. Urology, 72: 450-455. doi:10.1016/j.urology.2007. 11.127. PMID:18384850.
9. Everaerts, W., Gevaert, T., Nilius, B., and de Ridder, D. 2008. On the origin of bladder sensing: Tr(i)ps in urology. Neurourol. Urodyn. 27: 264-273. doi:10. 1002/nau.20511. PMID:17849480.
10. Hawthorn, M., Ferrante, J., Luchowski, E., Rutledge, A., Wei, X.Y., and Triggle, D.J. 1988. The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment.Pharmacol. Ther.2:101-118 doi:10.1111/j.1365-2036.1988.tb00677.x. PMID: 2856502.
11. Johnson, C.D., Melanaphy, D., Purse, A., Stokesberry, S.A., Dickson, P., and Zholos, A.V. 2009. Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am. J. Physiol. Heart Circ. Physiol. 296:H1868-H1877. doi:10.1152/ajpheart.01112.2008. PMID:19363131.
12. Mckemy, D.D., Neuhausser, W.M., and Julius, D. 2002. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 416: 52-58. doi:10.1038/nature719. PMID:11882888.
13. Mukerji, G., Waters, J., Chessell, I.P., Bountra, C., Agarwal, S.K., and Anand, P. 2006a. Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. BMC Urol. 6: 31. doi:10.1186/1471-2490-6-31. PMID:17192176.
14. Mukerji, G., Yiangou, Y., Corcoran, S.L., Selmer, I.S., Smith, G.D., Benham, C.D., Bountra, C., Agarwal, S.K., and Anand, P. 2006b. Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. BMC Urol. 6: 31. doi:10.1186/1471-2490-6-6. PMID:16519806.
15. Nomoto, Y., Yoshida, A., Ikeda, S., Kamikawa, Y., Harada, K., Ohwatashi, A., and Kawahira, K. 2008. Effect of menthol on detrusor smooth-muscle contraction and the micturition reflex in rats. Urology, 72: 701-705. doi:10.1016/j.urology. 2007.11.137. PMID:18336880.
16. Parsons, B.A., Drake, M.J., Gammie, A., Fry, C.H., and Vahabi, B. 2012. The validation of a functional, isolated pig bladder model for physiological experimentation. Front. Pharmacol. 3: 52. doi:10.3389/fphar.2012.00052. PMID: 22479248.
17. Peier, A.M., Moqrich, A., Hergarden, A.C., Reeve, A.J., Andersson, D.A., Story, G.M., Earley, T.J., Dragoni, I., Mcintyre, P., Bevan, S., and Patapoutian, A. 2002. A TRP channel that senses cold stimuli and menthol. Cell, 108: 705-15. doi:10.1016/S0092-8674(02)00652-9. PMID:11893340.
18. Sherkheli, M.A., Vogt-Eisele, A.K., Bura, D., Beltran Marques, L.R., Gisselmann, G., and Hatt, H. 2010. Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J. Pharm. Pharm. Sci. 13: 242-253. PMID:20816009.
19. Stein, R.J., Santos, S., Nagatomi, J., Hayashi, Y., Minnery, B.S., Xavier, M., Patel, A.S., Nelson, J.B., Futrell, W.J., Yoshimura, N., Chancellor, M.B., and de Miguel, F. 2004. Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J. Urol. 172: 1175-1178. doi:10.1097/01.ju.0000134880.55119. cf. PMID:15311065.
20. Streng, T., Axelsson, H.E., Hedlund, P., Andersson, D.A., Jordt, S.E., Bevan, S., Andersson, K.E., Hogestatt, E.D., and Zygmunt, P.M. 2008. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur. Urol. 53: 391-399. doi:10.1016/j.eururo.2007.10.024. PMID:18031925.
21. Wuest, M., Eichhorn, B., Braeter, M., Strugala, G., Michel, M., and Ravens, U. 2008. Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue. Pflügers Arch. 456: 349-358. doi:10.1007/s00424-007-0407-z. PMID:18157728.