메뉴 건너뛰기




Volumn 73, Issue 10, 2013, Pages 1095-1119

Abatacept: A review of its use in the management of rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; AZATHIOPRINE; CORTICOSTEROID; ETANERCEPT; HYDROXYCHLOROQUINE; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 84879978005     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0080-9     Document Type: Article
Times cited : (47)

References (91)
  • 1
    • 84864570470 scopus 로고    scopus 로고
    • Canadian Rheumatology Association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs
    • 21921096 10.3899/jrheum.110207 1:CAS:528:DC%2BC38XhsVartbbL
    • Bykerk VP, Akhavan P, Hazlewood GS, et al. Canadian Rheumatology Association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs. J Rheumatol. 2012;39(8):1559-82.
    • (2012) J Rheumatol , vol.39 , Issue.8 , pp. 1559-1582
    • Bykerk, V.P.1    Akhavan, P.2    Hazlewood, G.S.3
  • 2
    • 84857831726 scopus 로고    scopus 로고
    • Biologic rheumatoid arthritis therapies: Do we need more comparative effectiveness data?
    • 22385403 10.2165/11631320-000000000-00000 1:CAS:528:DC%2BC38XnsF2rtbw%3D
    • Levesque MC. Biologic rheumatoid arthritis therapies: do we need more comparative effectiveness data? BioDrugs. 2012;26(2):65-70.
    • (2012) BioDrugs , vol.26 , Issue.2 , pp. 65-70
    • Levesque, M.C.1
  • 3
    • 79952945682 scopus 로고    scopus 로고
    • Abatacept in the treatment of polyarticular JIA: Development, clinical utility, and place in therapy
    • 21340039 1:CAS:528:DC%2BC3MXhvVKkt7s%3D
    • Goldzweig O, Hashkes PJ. Abatacept in the treatment of polyarticular JIA: development, clinical utility, and place in therapy. Drug Des Devel Ther. 2011;5:61-70.
    • (2011) Drug des Devel Ther , vol.5 , pp. 61-70
    • Goldzweig, O.1    Hashkes, P.J.2
  • 4
    • 77957580515 scopus 로고    scopus 로고
    • Abatacept in difficult-to-treat juvenile idiopathic arthritis
    • 19707464 1:CAS:528:DC%2BD1MXjvVyhu74%3D
    • Kuemmerle-Deschner JB, Benseler S. Abatacept in difficult-to-treat juvenile idiopathic arthritis. Biologics. 2008;2(4):865-74.
    • (2008) Biologics , vol.2 , Issue.4 , pp. 865-874
    • Kuemmerle-Deschner, J.B.1    Benseler, S.2
  • 5
    • 79957483535 scopus 로고    scopus 로고
    • 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: Initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features
    • 10.1002/acr.20460
    • Beukelman T, Patkar NM, Saag KG, et al. 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res. 2011;63(4):465-82.
    • (2011) Arthritis Care Res , vol.63 , Issue.4 , pp. 465-482
    • Beukelman, T.1    Patkar, N.M.2    Saag, K.G.3
  • 6
    • 24144434927 scopus 로고    scopus 로고
    • Abatacept: A costimulatory inhibitor for treatment of rheumatoid arthritis
    • 16120053 10.1517/14712598.5.9.1245 1:CAS:528:DC%2BD2MXpslejtL0%3D
    • Teng GG, Turkiewicz AM, Moreland LW. Abatacept: a costimulatory inhibitor for treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2005;5(9):1245-54.
    • (2005) Expert Opin Biol Ther , vol.5 , Issue.9 , pp. 1245-1254
    • Teng, G.G.1    Turkiewicz, A.M.2    Moreland, L.W.3
  • 7
    • 33644967813 scopus 로고    scopus 로고
    • CTLA4Ig: Bridging the basic immunology with clinical application
    • 16546089 10.1016/j.immuni.2006.03.001 1:CAS:528:DC%2BD28XjtlKms7o%3D
    • Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 2006;24(3):233-8.
    • (2006) Immunity , vol.24 , Issue.3 , pp. 233-238
    • Bluestone, J.A.1    St Clair, E.W.2    Turka, L.A.3
  • 8
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • 10.1002/acr.21641 1:CAS:528:DC%2BC38XpsFOmu7o%3D
    • Singh JA, Furst DE, Bharat A, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2012;64(5):625-39.
    • (2012) Arthritis Care Res (Hoboken) , vol.64 , Issue.5 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3
  • 9
    • 77956682118 scopus 로고    scopus 로고
    • Subcutaneous administration of abatacept in patients with rheumatoid arthritis: Pharmacokinetics, safety and immunogenicity [abstract no. SAT0101]
    • Corbo M, Valencia X, Raymond R, et al. Subcutaneous administration of abatacept in patients with rheumatoid arthritis: pharmacokinetics, safety and immunogenicity [abstract no. SAT0101]. Ann Rheum Dis. 2009;68(Suppl. 3):574.
    • (2009) Ann Rheum Dis , vol.68 , Issue.SUPPL. 3 , pp. 574
    • Corbo, M.1    Valencia, X.2    Raymond, R.3
  • 10
    • 8344245611 scopus 로고    scopus 로고
    • Abatacept (CTLA4g; BMS-188667) significantly inhibits T-cell proliferation in vitro at clinically relevant concentrations [abstract no. THU0103]
    • Nadler S, Townsend R, Mikesell G, et al. Abatacept (CTLA4g; BMS-188667) significantly inhibits T-cell proliferation in vitro at clinically relevant concentrations [abstract no. THU0103]. Ann Rheum Dis. 2004;63:142-3.
    • (2004) Ann Rheum Dis , vol.63 , pp. 142-143
    • Nadler, S.1    Townsend, R.2    Mikesell, G.3
  • 11
    • 35448936267 scopus 로고    scopus 로고
    • Abatacept (CTLA4-Ig) modulates human T-cell proliferation and cytokine production but does not affect lipopolysaccharide-induced tumor necrosis factor alpha production by monocytes [abstract]
    • 10.1186/ar1542
    • Davis PM, Nadler SG, Rouleau KA, et al. Abatacept (CTLA4-Ig) modulates human T-cell proliferation and cytokine production but does not affect lipopolysaccharide-induced tumor necrosis factor alpha production by monocytes [abstract]. Arthritis Res Ther. 2005;7(Suppl. 1):P21.
    • (2005) Arthritis Res Ther , vol.7 , Issue.SUPPL. 1 , pp. 21
    • Davis, P.M.1    Nadler, S.G.2    Rouleau, K.A.3
  • 13
    • 62549154024 scopus 로고    scopus 로고
    • Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis
    • 19228144 10.1111/j.1742-7843.2009.00375.x 1:CAS:528:DC%2BD1MXnt1Cls70%3D
    • Korhonen R, Moilanen E. Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis. Basic Clin Pharmacol Toxicol. 2009;104(4):276-84.
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , Issue.4 , pp. 276-284
    • Korhonen, R.1    Moilanen, E.2
  • 14
    • 21644468434 scopus 로고    scopus 로고
    • The evolving clinical profile of abatacept (CTLA4-Ig): A novel co-stimulatory modulator for the treatment of rheumatoid arthritis
    • 15833145 10.1186/ar1688
    • Ruderman EM, Pope RM. The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis. Arthritis Res Ther. 2005;7(Suppl. 2):S21-5.
    • (2005) Arthritis Res Ther , vol.7 , Issue.SUPPL. 2
    • Ruderman, E.M.1    Pope, R.M.2
  • 15
    • 84863487145 scopus 로고    scopus 로고
    • Use of abatacept in rheumatoid arthritis: Recommendations based on current evidence
    • von Kempis J, Dudler J, Hasler P, et al. Use of abatacept in rheumatoid arthritis: recommendations based on current evidence. Swiss Med Wkly. 2012;142:w13581.
    • (2012) Swiss Med Wkly , vol.142 , pp. 13581
    • Von Kempis, J.1    Dudler, J.2    Hasler, P.3
  • 16
    • 77956410939 scopus 로고    scopus 로고
    • Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells
    • 20601593 10.4049/jimmunol.1001311 1:CAS:528:DC%2BC3cXptV2jsbs%3D
    • Platt AM, Gibson VB, Patakas A, et al. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J Immunol. 2010;185(3):1558-67.
    • (2010) J Immunol , vol.185 , Issue.3 , pp. 1558-1567
    • Platt, A.M.1    Gibson, V.B.2    Patakas, A.3
  • 17
    • 35948934705 scopus 로고    scopus 로고
    • Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity
    • 17787038 1:CAS:528:DC%2BD2sXhsVeksL3P
    • Davis PM, Abraham R, Xu L, et al. Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity. J Rheumatol. 2007;34(11):2204-10.
    • (2007) J Rheumatol , vol.34 , Issue.11 , pp. 2204-2210
    • Davis, P.M.1    Abraham, R.2    Xu, L.3
  • 18
    • 35448988946 scopus 로고    scopus 로고
    • Modeling and simulation of abatacept exposure and interleukin-6 response in support of recommended doses for rheumatoid arthritis
    • 17962428 10.1177/0091270007307573 1:CAS:528:DC%2BD2sXhtlGru7jM
    • Roy A, Mould DR, Wang X-F, et al. Modeling and simulation of abatacept exposure and interleukin-6 response in support of recommended doses for rheumatoid arthritis. J Clin Pharmacol. 2007;47(11):1408-20.
    • (2007) J Clin Pharmacol , vol.47 , Issue.11 , pp. 1408-1420
    • Roy, A.1    Mould, D.R.2    Wang, X.-F.3
  • 19
    • 37249033780 scopus 로고    scopus 로고
    • Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction
    • 17945538 10.1016/j.clim.2007.08.019 1:CAS:528:DC%2BD2sXhsVOlsL7L
    • Davis PM, Nadler SG, Stetsko DK, et al. Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction. Clin Immunol. 2008;126(1):38-47.
    • (2008) Clin Immunol , vol.126 , Issue.1 , pp. 38-47
    • Davis, P.M.1    Nadler, S.G.2    Stetsko, D.K.3
  • 20
    • 77951785328 scopus 로고    scopus 로고
    • Decreased circulating CD28-negative T cells in patients with rheumatoid arthritis treated with abatacept are correlated with clinical response
    • 20231200 10.3899/jrheum.091176 1:CAS:528:DC%2BC3cXnsFOrsrk%3D
    • Scarsi M, Ziglioli T, Airo P. Decreased circulating CD28-negative T cells in patients with rheumatoid arthritis treated with abatacept are correlated with clinical response. J Rheumatol. 2010;37(5):911-6.
    • (2010) J Rheumatol , vol.37 , Issue.5 , pp. 911-916
    • Scarsi, M.1    Ziglioli, T.2    Airo, P.3
  • 21
    • 84874413124 scopus 로고    scopus 로고
    • Abatacept (CTLA-4Ig) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis
    • 23203906 10.1002/art.37787 1:CAS:528:DC%2BC3sXjtlGqtLs%3D
    • Bonelli M, Ferner E, Göschl L, et al. Abatacept (CTLA-4Ig) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis. Arthritis Rheum. 2013;65(3):599-607.
    • (2013) Arthritis Rheum , vol.65 , Issue.3 , pp. 599-607
    • Bonelli, M.1    Ferner, E.2    Göschl, L.3
  • 22
    • 33750992180 scopus 로고    scopus 로고
    • Reduction of inflammatory biomarker response by abatacept in treatment of rheumatoid arthritis
    • 17014006 1:CAS:528:DC%2BD28Xhtlemu77P
    • Weisman MH, Durez P, Hallegua D, et al. Reduction of inflammatory biomarker response by abatacept in treatment of rheumatoid arthritis. J Rheumatol. 2006;33(11):2162-6.
    • (2006) J Rheumatol , vol.33 , Issue.11 , pp. 2162-2166
    • Weisman, M.H.1    Durez, P.2    Hallegua, D.3
  • 23
    • 84880847808 scopus 로고    scopus 로고
    • Tolerability and efficacy of abatacept in Japanese patients with rheumatoid arthritis: A phase i study
    • 10.1007/s10165-012-0722-x
    • Matsubara T, Yamana S, Tohma S, et al. Tolerability and efficacy of abatacept in Japanese patients with rheumatoid arthritis: a phase I study. Mod Rheumatol. 2012. doi: 10.1007/s10165-012-0722-x.
    • (2012) Mod Rheumatol
    • Matsubara, T.1    Yamana, S.2    Tohma, S.3
  • 24
    • 67549119579 scopus 로고    scopus 로고
    • Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: A histological, gene expression and dynamic magnetic resonance imaging pilot study
    • 18772191 10.1136/ard.2008.091876 1:CAS:528:DC%2BD1MXovVCms7o%3D
    • Buch MH, Boyle DL, Rosengren S, et al. Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study. Ann Rheum Dis. 2009;68(7):1220-7.
    • (2009) Ann Rheum Dis , vol.68 , Issue.7 , pp. 1220-1227
    • Buch, M.H.1    Boyle, D.L.2    Rosengren, S.3
  • 25
    • 23644455857 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve-month results of a phase IIb, double-blind, randomized, placebo-controlled trial
    • 16052582 10.1002/art.21201 1:CAS:528:DC%2BD2MXpslGhtr4%3D
    • Kremer JM, Dougados M, Emery P, et al. Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase IIb, double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 2005;52(8):2263-71.
    • (2005) Arthritis Rheum , vol.52 , Issue.8 , pp. 2263-2271
    • Kremer, J.M.1    Dougados, M.2    Emery, P.3
  • 26
    • 84894406712 scopus 로고    scopus 로고
    • Pharmacokinetics of subcutaneous abatacept support a fixed dosing regimen in adult patients with rheumatoid arthritis [abstract no. FRI0347]
    • Murthy B, Gao L, Yin J, et al. Pharmacokinetics of subcutaneous abatacept support a fixed dosing regimen in adult patients with rheumatoid arthritis [abstract no. FRI0347]. Ann Rheum Dis. 2011;70(Suppl. 3):460.
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 3 , pp. 460
    • Murthy, B.1    Gao, L.2    Yin, J.3
  • 27
    • 84894408156 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of subcutaneous abatacept in the presence or absence of an intravenous loading dose in patients with rheumatoid arthritis [abstract no. FRI0346]
    • Murthy B, Gao L, Vakkalagadda B, et al. Clinical pharmacokinetics of subcutaneous abatacept in the presence or absence of an intravenous loading dose in patients with rheumatoid arthritis [abstract no. FRI0346]. Ann Rheum Dis. 2011;70(Suppl. 3):459.
    • (2011) Ann Rheum Dis , vol.70 , Issue.SUPPL. 3 , pp. 459
    • Murthy, B.1    Gao, L.2    Vakkalagadda, B.3
  • 29
    • 84901253654 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 3 May 2013
    • European Medicines Agency. Orencia (abatacept): EU summary of product characteristics. 2012. http://www.emea.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/000701/WC500048935.pdf. Accessed 3 May 2013.
    • (2012) Orencia (Abatacept): EU Summary of Product Characteristics
  • 30
    • 84855708394 scopus 로고    scopus 로고
    • Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients
    • 22002809 10.1007/s10928-011-9221-5 1:CAS:528:DC%2BC3MXhsVyrsbbO
    • Hasegawa M, Imai Y, Hiraoka M, et al. Model-based determination of abatacept exposure in support of the recommended dose for Japanese rheumatoid arthritis patients. J Pharmacokinet Pharmacodyn. 2011;38(6):803-32.
    • (2011) J Pharmacokinet Pharmacodyn , vol.38 , Issue.6 , pp. 803-832
    • Hasegawa, M.1    Imai, Y.2    Hiraoka, M.3
  • 31
    • 0036275436 scopus 로고    scopus 로고
    • Costimulatory blockade in patients with rheumatoid arthritis: A pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion
    • 12115176 10.1002/art.10294 1:CAS:528:DC%2BD38Xltlanurs%3D
    • Moreland LW, Alten R, Van den Bosch F, et al. Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum. 2002;46(6):1470-9.
    • (2002) Arthritis Rheum , vol.46 , Issue.6 , pp. 1470-1479
    • Moreland, L.W.1    Alten, R.2    Van Den Bosch, F.3
  • 32
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • 14614165 10.1056/NEJMoa035075 1:CAS:528:DC%2BD3sXptVGnurs%3D
    • Kremer JM, Westhovens R, Leon M, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med. 2003;349(20):1907-15.
    • (2003) N Engl J Med , vol.349 , Issue.20 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 33
    • 84883163862 scopus 로고    scopus 로고
    • Phase II dose-response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate
    • 22684431 10.1007/s10165-012-0668-z 1:CAS:528:DC%2BC3sXktFeltL8%3D
    • Takeuchi T, Matsubara T, Nitobe T, et al. Phase II dose-response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate. Mod Rheumatol. 2013;23(2):226-35.
    • (2013) Mod Rheumatol , vol.23 , Issue.2 , pp. 226-235
    • Takeuchi, T.1    Matsubara, T.2    Nitobe, T.3
  • 34
    • 66149093043 scopus 로고    scopus 로고
    • Safety and efficacy of the selective costimulation modulator abatacept in patients with rheumatoid arthritis receiving background methotrexate: A 5-year extended phase IIB study
    • 19273451 10.3899/jrheum.080813 1:CAS:528:DC%2BD1MXkvFemt7s%3D
    • Westhovens R, Kremer JM, Moreland LW, et al. Safety and efficacy of the selective costimulation modulator abatacept in patients with rheumatoid arthritis receiving background methotrexate: a 5-year extended phase IIB study. J Rheumatol. 2009;36(4):736-42.
    • (2009) J Rheumatol , vol.36 , Issue.4 , pp. 736-742
    • Westhovens, R.1    Kremer, J.M.2    Moreland, L.W.3
  • 35
    • 77954426551 scopus 로고    scopus 로고
    • Consistent safety and sustained improvement in disease activity and treatment response over 7 years of abatacept treatment in biologic-naive patients with RA [abstract no. SAT0108]
    • Westhovens R, Kremer JM, Emery P, et al. Consistent safety and sustained improvement in disease activity and treatment response over 7 years of abatacept treatment in biologic-naive patients with RA [abstract no. SAT0108]. Ann Rheum Dis. 2009;68(Suppl. 3):577.
    • (2009) Ann Rheum Dis , vol.68 , Issue.SUPPL. 3 , pp. 577
    • Westhovens, R.1    Kremer, J.M.2    Emery, P.3
  • 36
    • 33745291091 scopus 로고    scopus 로고
    • Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: A randomized trial
    • 16785475 10.7326/0003-4819-144-12-200606200-00003 1:CAS:528: DC%2BD28XntF2jsr8%3D
    • Kremer JM, Genant HK, Moreland LW, et al. Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med. 2006;144(12):865-76.
    • (2006) Ann Intern Med , vol.144 , Issue.12 , pp. 865-876
    • Kremer, J.M.1    Genant, H.K.2    Moreland, L.W.3
  • 37
    • 47949106400 scopus 로고    scopus 로고
    • Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: A phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate
    • 18055472 10.1136/ard.2007.080002 1:CAS:528:DC%2BD1cXhtVSktbvJ
    • Schiff M, Keiserman M, Codding C, et al. Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis. 2008;67(8):1096-103.
    • (2008) Ann Rheum Dis , vol.67 , Issue.8 , pp. 1096-1103
    • Schiff, M.1    Keiserman, M.2    Codding, C.3
  • 38
    • 84880206715 scopus 로고    scopus 로고
    • Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: The ASSET randomised controlled trial
    • 10.1136/annrheumdis-2012-201611
    • Conaghan PG, Durez P, Alten RE, et al. Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial. Ann Rheum Dis. 2012. doi: 10.1136/annrheumdis-2012-201611.
    • (2012) Ann Rheum Dis
    • Conaghan, P.G.1    Durez, P.2    Alten, R.E.3
  • 39
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
    • 16162882 10.1056/NEJMoa050524 1:CAS:528:DC%2BD2MXhtVWhsbnI
    • Genovese MC, Becker J-C, Schiff M, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N Engl J Med. 2005;353(11):1114-23.
    • (2005) N Engl J Med , vol.353 , Issue.11 , pp. 1114-1123
    • Genovese, M.C.1    Becker, J.-C.2    Schiff, M.3
  • 40
    • 65349176911 scopus 로고    scopus 로고
    • Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors
    • 19124524 10.1136/ard.2008.101121 1:CAS:528:DC%2BD1MXhsF2itrzO
    • Westhovens R, Robles M, Ximenes AC, et al. Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis. 2009;68(12):1870-7.
    • (2009) Ann Rheum Dis , vol.68 , Issue.12 , pp. 1870-1877
    • Westhovens, R.1    Robles, M.2    Ximenes, A.C.3
  • 41
    • 70449709528 scopus 로고    scopus 로고
    • The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-tumour necrosis factor therapy or were directly switched to abatacept: The ARRIVE trial
    • 19074911 10.1136/ard.2008.099218 1:CAS:528:DC%2BD1MXhs1WitbfN
    • Schiff M, Pritchard C, Huffstutter JE, et al. The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-tumour necrosis factor therapy or were directly switched to abatacept: the ARRIVE trial. Ann Rheum Dis. 2009;68(11):1708-14.
    • (2009) Ann Rheum Dis , vol.68 , Issue.11 , pp. 1708-1714
    • Schiff, M.1    Pritchard, C.2    Huffstutter, J.E.3
  • 42
    • 84879933095 scopus 로고    scopus 로고
    • Real-world efficacy and safety of abatacept treatment for RA: 12-month interim analysis of the ACTION study [abstract no. AB0531]
    • Nüβlein H, Alten R, Galeazzi M, et al. Real-world efficacy and safety of abatacept treatment for RA: 12-month interim analysis of the ACTION study [abstract no. AB0531]. Ann Rheum Dis. 2012;71(Suppl. 3):668.
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 668
    • Nülein, H.1    Alten, R.2    Galeazzi, M.3
  • 43
    • 84879933095 scopus 로고    scopus 로고
    • Effect of prior therapy on the efficacy and safety of abatacept: 6-month analysis of the ACTION study [abstract no. AB0532]
    • Nüβlein H, Alten R, Galeazzi M, et al. Effect of prior therapy on the efficacy and safety of abatacept: 6-month analysis of the ACTION study [abstract no. AB0532]. Ann Rheum Dis. 2012;71(Suppl. 3):668.
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 668
    • Nülein, H.1    Alten, R.2    Galeazzi, M.3
  • 44
    • 84867401801 scopus 로고    scopus 로고
    • Positivity for anti-cyclic citrullinated peptide is associated with a better response to abatacept: Data from the 'Orencia and Rheumatoid Arthritis' registry
    • 22615458 10.1136/annrheumdis-2011-201109 1:CAS:528:DC%2BC38XhvV2nsbfN
    • Gottenberg JE, Ravaud P, Cantagrel A, et al. Positivity for anti-cyclic citrullinated peptide is associated with a better response to abatacept: data from the 'Orencia and Rheumatoid Arthritis' registry. Ann Rheum Dis. 2012;71(11):1815-9.
    • (2012) Ann Rheum Dis , vol.71 , Issue.11 , pp. 1815-1819
    • Gottenberg, J.E.1    Ravaud, P.2    Cantagrel, A.3
  • 45
    • 77956678811 scopus 로고    scopus 로고
    • Abatacept increases the proportion of patients who remain free from structural damage progression through 5 years in methotrexate inadequate responders with RA [abstract no. FRI0253]
    • Genant HK, Peterfy C, Westhovens R, et al. Abatacept increases the proportion of patients who remain free from structural damage progression through 5 years in methotrexate inadequate responders with RA [abstract no. FRI0253]. Ann Rheum Dis. 2009;68(Suppl. 3):440.
    • (2009) Ann Rheum Dis , vol.68 , Issue.SUPPL. 3 , pp. 440
    • Genant, H.K.1    Peterfy, C.2    Westhovens, R.3
  • 46
    • 78449261480 scopus 로고    scopus 로고
    • Time course of improvement in ACR core components in patients with early rheumatoid arthritis (RA) treated with abatacept (ABA) + methotrexate (MTX) [abstract no. FRI0201]
    • Durez P, Bathon J, Becker JC, et al. Time course of improvement in ACR core components in patients with early rheumatoid arthritis (RA) treated with abatacept (ABA) + methotrexate (MTX) [abstract no. FRI0201]. Ann Rheum Dis. 2010;69(Suppl. 3):382.
    • (2010) Ann Rheum Dis , vol.69 , Issue.SUPPL. 3 , pp. 382
    • Durez, P.1    Bathon, J.2    Becker, J.C.3
  • 47
    • 85081781486 scopus 로고    scopus 로고
    • Disease remission, radiographic non-progression and normalization of function achieved at year 1 are sustained long-term in a majority of patients: 5-year outcomes with abatacept in biologic-naive patients
    • [abstract no. 1657] 16-21 Oct 2009; Philadelphia (PA)
    • Westhovens R, Dougados M, Hall S, et al. Disease remission, radiographic non-progression and normalization of function achieved at year 1 are sustained long-term in a majority of patients: 5-year outcomes with abatacept in biologic-naive patients [abstract no. 1657]. 2009 American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting; 16-21 Oct 2009; Philadelphia (PA).
    • 2009 American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting
    • Westhovens, R.1    Dougados, M.2    Hall, S.3
  • 48
    • 80053571014 scopus 로고    scopus 로고
    • Sustained disease remission and inhibition of radiographic progression in methotrexate-naive patients with rheumatoid arthritis and poor prognostic factors treated with abatacept: 2-year outcomes
    • 21821865 10.1136/ard.2010.145268 1:CAS:528:DC%2BC3MXhsFamsLrN
    • Bathon J, Robles M, Ximenes AC, et al. Sustained disease remission and inhibition of radiographic progression in methotrexate-naive patients with rheumatoid arthritis and poor prognostic factors treated with abatacept: 2-year outcomes. Ann Rheum Dis. 2011;70(11):1949-56.
    • (2011) Ann Rheum Dis , vol.70 , Issue.11 , pp. 1949-1956
    • Bathon, J.1    Robles, M.2    Ximenes, A.C.3
  • 49
    • 80155146608 scopus 로고    scopus 로고
    • Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoid arthritis who achieve radiographic nonprogression
    • 21885491 10.3899/jrheum.110054 1:CAS:528:DC%2BC3MXhs1GltLzI
    • Wells AF, Westhovens R, Reed DM, et al. Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoid arthritis who achieve radiographic nonprogression. J Rheumatol. 2011;38(11):2362-8.
    • (2011) J Rheumatol , vol.38 , Issue.11 , pp. 2362-2368
    • Wells, A.F.1    Westhovens, R.2    Reed, D.M.3
  • 50
    • 42449098374 scopus 로고    scopus 로고
    • Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate
    • 18383390 10.1002/art.23397 1:CAS:528:DC%2BD1cXltFGisb8%3D
    • Kremer JM, Genant HK, Moreland LW, et al. Results of a two-year followup study of patients with rheumatoid arthritis who received a combination of abatacept and methotrexate. Arthritis Rheum. 2008;58(4):953-63.
    • (2008) Arthritis Rheum , vol.58 , Issue.4 , pp. 953-963
    • Kremer, J.M.1    Genant, H.K.2    Moreland, L.W.3
  • 51
    • 47949111861 scopus 로고    scopus 로고
    • Abatacept inhibits progression of structural damage in rheumatoid arthritis: Results from the long-term extension of the AIM trial
    • 18086727 10.1136/ard.2007.085084 1:CAS:528:DC%2BD1cXhtVSktbvO
    • Genant HK, Peterfy CG, Westhovens R, et al. Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial. Ann Rheum Dis. 2008;67(8):1084-9.
    • (2008) Ann Rheum Dis , vol.67 , Issue.8 , pp. 1084-1089
    • Genant, H.K.1    Peterfy, C.G.2    Westhovens, R.3
  • 52
    • 80052508096 scopus 로고    scopus 로고
    • Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial
    • 21893583 10.1136/ard.2010.139345 1:CAS:528:DC%2BC3MXhtl2rsrzJ
    • Kremer JM, Russell AS, Emery P, et al. Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial. Ann Rheum Dis. 2011;70(10):1826-30.
    • (2011) Ann Rheum Dis , vol.70 , Issue.10 , pp. 1826-1830
    • Kremer, J.M.1    Russell, A.S.2    Emery, P.3
  • 53
    • 80053571696 scopus 로고    scopus 로고
    • Clinical response and tolerability to abatacept in patients with rheumatoid arthritis previously treated with infliximab or abatacept: Open-label extension of the ATTEST Study
    • 21914628 10.1136/annrheumdis-2011-200316 1:CAS:528:DC%2BC3MXhsFamsLvP
    • Schiff M, Keiserman M, Codding C, et al. Clinical response and tolerability to abatacept in patients with rheumatoid arthritis previously treated with infliximab or abatacept: open-label extension of the ATTEST Study. Ann Rheum Dis. 2011;70(11):2003-7.
    • (2011) Ann Rheum Dis , vol.70 , Issue.11 , pp. 2003-2007
    • Schiff, M.1    Keiserman, M.2    Codding, C.3
  • 54
    • 33846859159 scopus 로고    scopus 로고
    • Abatacept improves both the physical and mental health of patients with rheumatoid arthritis who have inadequate response to methotrexate treatment
    • 16984942 10.1136/ard.2006.057018 1:CAS:528:DC%2BD2sXislChs7Y%3D
    • Russell AS, Wallenstein GV, Li T, et al. Abatacept improves both the physical and mental health of patients with rheumatoid arthritis who have inadequate response to methotrexate treatment. Ann Rheum Dis. 2007;66(2):189-94.
    • (2007) Ann Rheum Dis , vol.66 , Issue.2 , pp. 189-194
    • Russell, A.S.1    Wallenstein, G.V.2    Li, T.3
  • 55
    • 77957273826 scopus 로고    scopus 로고
    • Investigation into the impact of abatacept on sleep quality in patients with rheumatoid arthritis, and the validity of the MOS-Sleep questionnaire Sleep Disturbance Scale
    • 20610444 10.1136/ard.2009.119727
    • Wells G, Li T, Tugwell P. Investigation into the impact of abatacept on sleep quality in patients with rheumatoid arthritis, and the validity of the MOS-Sleep questionnaire Sleep Disturbance Scale. Ann Rheum Dis. 2010;69(10):1768-73.
    • (2010) Ann Rheum Dis , vol.69 , Issue.10 , pp. 1768-1773
    • Wells, G.1    Li, T.2    Tugwell, P.3
  • 56
    • 43549121445 scopus 로고    scopus 로고
    • Decreased external home help use with improved clinical status in rheumatoid arthritis: An exploratory analysis of the Abatacept in Inadequate responders to Methotrexate (AIM) trial
    • 18498922 10.1016/j.clinthera.2008.03.015 1:CAS:528:DC%2BD1cXhtVWltLbK
    • Li T, Gignac M, Wells G, et al. Decreased external home help use with improved clinical status in rheumatoid arthritis: an exploratory analysis of the Abatacept in Inadequate responders to Methotrexate (AIM) trial. Clin Ther. 2008;30(4):734-48.
    • (2008) Clin Ther , vol.30 , Issue.4 , pp. 734-748
    • Li, T.1    Gignac, M.2    Wells, G.3
  • 57
    • 41849120516 scopus 로고    scopus 로고
    • Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy
    • 17921185 10.1136/ard.2007.074773 1:CAS:528:DC%2BD1cXltlSksrg%3D
    • Genovese MC, Schiff M, Luggen M, et al. Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy. Ann Rheum Dis. 2008;67(4):547-54.
    • (2008) Ann Rheum Dis , vol.67 , Issue.4 , pp. 547-554
    • Genovese, M.C.1    Schiff, M.2    Luggen, M.3
  • 58
    • 84864554419 scopus 로고    scopus 로고
    • Longterm safety and efficacy of abatacept through 5 years of treatment in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor inhibitor therapy
    • 22798265 10.3899/jrheum.111531 1:CAS:528:DC%2BC38XhsVartbbP
    • Genovese MC, Schiff M, Luggen M, et al. Longterm safety and efficacy of abatacept through 5 years of treatment in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor inhibitor therapy. J Rheumatol. 2012;39(8):1546-54.
    • (2012) J Rheumatol , vol.39 , Issue.8 , pp. 1546-1554
    • Genovese, M.C.1    Schiff, M.2    Luggen, M.3
  • 59
    • 33749586734 scopus 로고    scopus 로고
    • Improved health-related quality of life for rheumatoid arthritis patients treated with abatacept who have inadequate response to anti-TNF therapy in a double-blind, placebo-controlled, multicentre randomized clinical trial
    • 10.1093/rheumatology/kel066 1:CAS:528:DC%2BD28XhtVWlt7nJ
    • Westhovens R, Cole JC, Li T, et al. Improved health-related quality of life for rheumatoid arthritis patients treated with abatacept who have inadequate response to anti-TNF therapy in a double-blind, placebo-controlled, multicentre randomized clinical trial. Rheumatology (Oxford). 2006;45(10):1238-46.
    • (2006) Rheumatology (Oxford) , vol.45 , Issue.10 , pp. 1238-1246
    • Westhovens, R.1    Cole, J.C.2    Li, T.3
  • 60
    • 79959622170 scopus 로고    scopus 로고
    • Improvements in participation in usual daily activities in patients with rheumatoid arthritis treated with abatacept
    • 21296603 10.1016/j.jval.2010.10.008
    • Li T, Wells G, Westhovens R, et al. Improvements in participation in usual daily activities in patients with rheumatoid arthritis treated with abatacept. Value Health. 2011;14(2):361-70.
    • (2011) Value Health , vol.14 , Issue.2 , pp. 361-370
    • Li, T.1    Wells, G.2    Westhovens, R.3
  • 61
    • 84872789142 scopus 로고    scopus 로고
    • A subcutaneous administration regimen for abatacept in patients with rheumatoid arthritis: Pharmacokinetics, safety and immunogenicity [abstract no. 376]
    • Corbo M, Valencia X, Raymond R, et al. A subcutaneous administration regimen for abatacept in patients with rheumatoid arthritis: pharmacokinetics, safety and immunogenicity [abstract no. 376]. Arthritis Rheum. 2008;58(Suppl. 9):S307.
    • (2008) Arthritis Rheum , vol.58 , Issue.SUPPL. 9 , pp. 307
    • Corbo, M.1    Valencia, X.2    Raymond, R.3
  • 62
    • 80053493531 scopus 로고    scopus 로고
    • Subcutaneous abatacept versus intravenous abatacept: A phase IIIb noninferiority study in patients with an inadequate response to methotrexate
    • 21618201 10.1002/art.30463 1:CAS:528:DC%2BC3MXht1amtLnJ
    • Genovese MC, Covarrubias A, Leon G, et al. Subcutaneous abatacept versus intravenous abatacept: a phase IIIb noninferiority study in patients with an inadequate response to methotrexate. Arthritis Rheum. 2011;63(10):2854-64.
    • (2011) Arthritis Rheum , vol.63 , Issue.10 , pp. 2854-2864
    • Genovese, M.C.1    Covarrubias, A.2    Leon, G.3
  • 63
    • 84894409467 scopus 로고    scopus 로고
    • A multi-center, double-dummy, double-blind study of subcutaneous (SC) abatacept (ABA) compared with intraveneous (IV) ABA in Japanese rheumatoid arthritis patients with inadequate response to methotrexate [abstract no. THU0125]
    • Matsubara T, Inoue H, Iwahashi M, et al. A multi-center, double-dummy, double-blind study of subcutaneous (SC) abatacept (ABA) compared with intraveneous (IV) ABA in Japanese rheumatoid arthritis patients with inadequate response to methotrexate [abstract no. THU0125]. Ann Rheum Dis. 2012;71(Suppl. 3):197.
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 197
    • Matsubara, T.1    Inoue, H.2    Iwahashi, M.3
  • 64
    • 84860916327 scopus 로고    scopus 로고
    • Abatacept in subjects who switch from intravenous to subcutaneous therapy: Results from the phase IIIb ATTUNE study
    • 22302417 10.1136/annrheumdis-2011-200355 1:CAS:528:DC%2BC38XpvVShu74%3D
    • Keystone EC, Kremer JM, Russell A, et al. Abatacept in subjects who switch from intravenous to subcutaneous therapy: results from the phase IIIb ATTUNE study. Ann Rheum Dis. 2012;71(6):857-61.
    • (2012) Ann Rheum Dis , vol.71 , Issue.6 , pp. 857-861
    • Keystone, E.C.1    Kremer, J.M.2    Russell, A.3
  • 65
    • 84871813585 scopus 로고    scopus 로고
    • Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: Findings of a phase IIIb, multinational, prospective, randomized study
    • 23169319 10.1002/art.37711 1:CAS:528:DC%2BC3sXmslyg
    • Weinblatt ME, Schiff M, Valente R, et al. Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: findings of a phase IIIb, multinational, prospective, randomized study. Arthritis Rheum. 2013;65(1):28-38.
    • (2013) Arthritis Rheum , vol.65 , Issue.1 , pp. 28-38
    • Weinblatt, M.E.1    Schiff, M.2    Valente, R.3
  • 66
    • 82955189834 scopus 로고    scopus 로고
    • Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: Impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase IIIb ALLOW study)
    • 21917824 10.1136/annrheumdis-2011-200344 1:CAS:528:DC%2BC38Xhs1yitbY%3D
    • Kaine J, Gladstein G, Strusberg I, et al. Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase IIIb ALLOW study). Ann Rheum Dis. 2012;71(1):38-44.
    • (2012) Ann Rheum Dis , vol.71 , Issue.1 , pp. 38-44
    • Kaine, J.1    Gladstein, G.2    Strusberg, I.3
  • 67
    • 84876701598 scopus 로고    scopus 로고
    • Immunogenicity, safety and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: Results from a phase III, international, multicenter, parallel-arm, open-label study
    • 10.1002/acr.21876 1:CAS:528:DC%2BC3sXpt1Cgsb0%3D
    • Nash P, Nayiager S, Genovese MC, et al. Immunogenicity, safety and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: results from a phase III, international, multicenter, parallel-arm, open-label study. Arthritis Care Res. 2013;65(5):718-28.
    • (2013) Arthritis Care Res , vol.65 , Issue.5 , pp. 718-728
    • Nash, P.1    Nayiager, S.2    Genovese, M.C.3
  • 68
    • 85081783863 scopus 로고    scopus 로고
    • Subcutaneous (SC) abatacept (ABA) versus intravenous (IV) ABA in patients (pts) with rheumatoid arthritis: Long-term data from the ACQUIRE (Abatacept Comparison of Sub[QU]cutaneous versus Intravenous in Inadequate Responders to Methotrexate) trial
    • [abstract no. 402] 5-9 Nov 2011; Chicago (IL)
    • Genovese MC, Cobos AC, Leon G, et al. Subcutaneous (SC) abatacept (ABA) versus intravenous (IV) ABA in patients (pts) with rheumatoid arthritis: long-term data from the ACQUIRE (Abatacept Comparison of Sub[QU]cutaneous versus Intravenous in Inadequate Responders to Methotrexate) trial [abstract no. 402]. 2011 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals; 5-9 Nov 2011; Chicago (IL).
    • 2011 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals
    • Genovese, M.C.1    Cobos, A.C.2    Leon, G.3
  • 69
    • 85081781877 scopus 로고    scopus 로고
    • Head-to-head comparison of subcutaneous abatacept versus adalimumab on background methotrexate in RA: Two year results from the AMPLE study
    • [abstract no. OP0044] 12-15 Jun 2013; Madrid
    • Schiff M, Weinblatt M, Valente R, et al. Head-to-head comparison of subcutaneous abatacept versus adalimumab on background methotrexate in RA: two year results from the AMPLE study [abstract no. OP0044]. 2013 Annual European Congress of Rheumatology; 12-15 Jun 2013; Madrid.
    • 2013 Annual European Congress of Rheumatology
    • Schiff, M.1    Weinblatt, M.2    Valente, R.3
  • 70
    • 48349093002 scopus 로고    scopus 로고
    • Abatacept in children with juvenile idiopathic arthritis: A randomised, double-blind, placebo-controlled withdrawal trial
    • 18632147 10.1016/S0140-6736(08)60998-8 1:CAS:528:DC%2BD1cXpt1GqtLc%3D
    • Ruperto N, Lovell DJ, Quartier P, et al. Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial. Lancet. 2008;372(9636):383-91.
    • (2008) Lancet , vol.372 , Issue.9636 , pp. 383-391
    • Ruperto, N.1    Lovell, D.J.2    Quartier, P.3
  • 71
    • 77952898132 scopus 로고    scopus 로고
    • Long-term safety and efficacy of abatacept in children with juvenile idiopathic arthritis
    • 20191582 10.1002/art.27431 1:CAS:528:DC%2BC3cXhtFGmsr%2FI
    • Ruperto N, Lovell DJ, Quartier P, et al. Long-term safety and efficacy of abatacept in children with juvenile idiopathic arthritis. Arthritis Rheum. 2010;62(6):1792-802.
    • (2010) Arthritis Rheum , vol.62 , Issue.6 , pp. 1792-1802
    • Ruperto, N.1    Lovell, D.J.2    Quartier, P.3
  • 72
    • 79952063531 scopus 로고    scopus 로고
    • Abatacept improves health-related quality of life, pain, sleep quality, and daily participation in subjects with juvenile idiopathic arthritis
    • 10.1002/acr.20283
    • Ruperto N, Lovell DJ, Li T, et al. Abatacept improves health-related quality of life, pain, sleep quality, and daily participation in subjects with juvenile idiopathic arthritis. Arthritis Care Res. 2010;62(11):1542-51.
    • (2010) Arthritis Care Res , vol.62 , Issue.11 , pp. 1542-1551
    • Ruperto, N.1    Lovell, D.J.2    Li, T.3
  • 73
    • 33749365296 scopus 로고    scopus 로고
    • Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: A one-year randomized, placebo-controlled study
    • 16947384 10.1002/art.22070 1:CAS:528:DC%2BD28XhtFWksLjJ
    • Weinblatt M, Combe B, Covucci A, et al. Safety of the selective costimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and nonbiologic disease-modifying antirheumatic drugs: a one-year randomized, placebo-controlled study. Arthritis Rheum. 2006;54(9):2807-16.
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2807-2816
    • Weinblatt, M.1    Combe, B.2    Covucci, A.3
  • 74
    • 84878631800 scopus 로고    scopus 로고
    • Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: Integrated analyses of up to 8 years of treatment from the abatacept clinical trial program
    • 10.3899/jrheum.120906
    • Weinblatt ME, Moreland LW, Westhovens R, et al. Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: integrated analyses of up to 8 years of treatment from the abatacept clinical trial program. J Rheumatol. 2013. doi: 10.3899/jrheum.120906.
    • (2013) J Rheumatol
    • Weinblatt, M.E.1    Moreland, L.W.2    Westhovens, R.3
  • 75
    • 84894407452 scopus 로고    scopus 로고
    • Safety of SC abatacept in patients with RA: Update from pooled clinical trial data [abstract no. AB0567]
    • Alten R, Kaine J, Keystone E, et al. Safety of SC abatacept in patients with RA: update from pooled clinical trial data [abstract no. AB0567]. Ann Rheum Dis. 2012;71(Suppl. 3):670.
    • (2012) Ann Rheum Dis , vol.71 , Issue.SUPPL. 3 , pp. 670
    • Alten, R.1    Kaine, J.2    Keystone, E.3
  • 76
    • 77950663683 scopus 로고    scopus 로고
    • Infections requiring hospitalization in the abatacept clinical development program: An epidemiological assessment
    • 20398273 10.1186/ar2984
    • Simon TA, Askling J, Lacaille D, et al. Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment. Arthritis Res Ther. 2010;12(2):R67.
    • (2010) Arthritis Res Ther , vol.12 , Issue.2 , pp. 67
    • Simon, T.A.1    Askling, J.2    Lacaille, D.3
  • 77
    • 72249096209 scopus 로고    scopus 로고
    • Malignancies in the rheumatoid arthritis abatacept clinical development programme: An epidemiological assessment
    • 19054822 10.1136/ard.2008.097527 1:CAS:528:DC%2BD1MXhsF2itr%2FO
    • Simon TA, Smitten AL, Franklin J, et al. Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment. Ann Rheum Dis. 2009;68(12):1819-26.
    • (2009) Ann Rheum Dis , vol.68 , Issue.12 , pp. 1819-1826
    • Simon, T.A.1    Smitten, A.L.2    Franklin, J.3
  • 78
    • 84879924170 scopus 로고    scopus 로고
    • Immunogenicity is low and transient with intravenous (IV) abatacept therapy: Results from a large pooled analysis of 3985 patients (pts) with rheumatoid arthritis (RA) and up to 8 years' exposure
    • [abstract no. 2191] 5-9 Nov 2011; Chicago (IL)
    • Weinblatt ME, Genovese MC, Schiff MH, et al. Immunogenicity is low and transient with intravenous (IV) abatacept therapy: results from a large pooled analysis of 3985 patients (pts) with rheumatoid arthritis (RA) and up to 8 years' exposure [abstract no. 2191]. 2011 American College of Rheumatology and Association of Rheumatology Health Professionals Annual Scientific Meeting; 5-9 Nov 2011; Chicago (IL).
    • 2011 American College of Rheumatology and Association of Rheumatology Health Professionals Annual Scientific Meeting
    • Weinblatt, M.E.1    Genovese, M.C.2    Schiff, M.H.3
  • 79
    • 79960466699 scopus 로고    scopus 로고
    • Safety and efficacy of abatacept over 4 years of treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate in the AIM trial [abstract no. 153]
    • Russell AS, Kremer JM, Emery P, et al. Safety and efficacy of abatacept over 4 years of treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate in the AIM trial [abstract no. 153]. J Rheumatol. 2009;36(11):2608-9.
    • (2009) J Rheumatol , vol.36 , Issue.11 , pp. 2608-2609
    • Russell, A.S.1    Kremer, J.M.2    Emery, P.3
  • 80
    • 40649111668 scopus 로고    scopus 로고
    • The risk of hospitalized infection in patients with rheumatoid arthritis
    • 18260176
    • Smitten AL, Choi HK, Hochberg MC, et al. The risk of hospitalized infection in patients with rheumatoid arthritis. J Rheumatol. 2008;35(3):387-93.
    • (2008) J Rheumatol , vol.35 , Issue.3 , pp. 387-393
    • Smitten, A.L.1    Choi, H.K.2    Hochberg, M.C.3
  • 81
    • 44049085950 scopus 로고    scopus 로고
    • A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis
    • 18433475 10.1186/ar2404
    • Smitten AL, Simon TA, Hochberg MC, et al. A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis. Arthritis Res Ther. 2008;10(2):R45.
    • (2008) Arthritis Res Ther , vol.10 , Issue.2 , pp. 45
    • Smitten, A.L.1    Simon, T.A.2    Hochberg, M.C.3
  • 83
    • 83155163741 scopus 로고    scopus 로고
    • Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: A network meta-analysis
    • 10.1186/ar3537 1:CAS:528:DC%2BC38Xlt1Cisbg%3D
    • Guyot P, Taylor P, Christensen R, et al. Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis. Arthrtis Res Ther. 2011;13:R204.
    • (2011) Arthrtis Res Ther , vol.13 , pp. 204
    • Guyot, P.1    Taylor, P.2    Christensen, R.3
  • 84
    • 77953696525 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
    • 20444750 10.1136/ard.2009.126532 1:CAS:528:DC%2BC3cXos1GiurY%3D
    • Smolen JS, Landewé R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2010;69(6):964-75.
    • (2010) Ann Rheum Dis , vol.69 , Issue.6 , pp. 964-975
    • Smolen, J.S.1    Landewé, R.2    Breedveld, F.C.3
  • 85
    • 84872802995 scopus 로고    scopus 로고
    • Abatacept use in rheumatoid arthritis: Evidence review and recommendations
    • 22766432
    • Martín Mola E, Balsa A, Martínez Taboada V, et al. Abatacept use in rheumatoid arthritis: evidence review and recommendations. Reumatol Clin. 2013;9(1):5-17.
    • (2013) Reumatol Clin , vol.9 , Issue.1 , pp. 5-17
    • Martín Mola, E.1    Balsa, A.2    Martínez Taboada, V.3
  • 86
    • 84993735979 scopus 로고    scopus 로고
    • The efficacy and safety of abatacept in rheumatoid arthritis
    • 22870440 10.1177/1759720X09360429 1:CAS:528:DC%2BC3MXhs1WgtbnL
    • Westhovens R, Verschueren P. The efficacy and safety of abatacept in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2010;2(2):89-94.
    • (2010) Ther Adv Musculoskelet Dis , vol.2 , Issue.2 , pp. 89-94
    • Westhovens, R.1    Verschueren, P.2
  • 87
    • 84879948640 scopus 로고    scopus 로고
    • European Medicines Agency Accessed 3 May 2013
    • European Medicines Agency. Remicade (infliximab): EU summary of product characteristics. 2012. http://www.emea.europa.eu/docs/en-GB/document-library/ EPAR-Product-Information/human/000240/WC500050888.pdf. Accessed 3 May 2013.
    • (2012) Remicade (Infliximab): EU Summary of Product Characteristics
  • 88
    • 84877057977 scopus 로고    scopus 로고
    • Janssen Biotech Inc. Accessed 3 May 2013
    • Janssen Biotech Inc. Remicade (infliximab): US prescribing information. 2011. http://www.remicade.com/remicade/assets/hcp-ppi.pdf. Accessed 3 May 2013.
    • (2011) Remicade (Infliximab): US Prescribing Information
  • 89
    • 33846853779 scopus 로고    scopus 로고
    • Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: A randomised clinical trial
    • 16935912 10.1136/ard.2006.055111 1:CAS:528:DC%2BD2sXislChsLo%3D
    • Weinblatt M, Schiff M, Goldman A, et al. Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann Rheum Dis. 2007;66(2):228-34.
    • (2007) Ann Rheum Dis , vol.66 , Issue.2 , pp. 228-234
    • Weinblatt, M.1    Schiff, M.2    Goldman, A.3
  • 90
    • 77953698486 scopus 로고    scopus 로고
    • Economic aspects of treatment options in rheumatoid arthritis: A systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis
    • 20447950 10.1136/ard.2009.126714
    • Schoels M, Wong J, Scott DL, et al. Economic aspects of treatment options in rheumatoid arthritis: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2010;69(6):995-1003.
    • (2010) Ann Rheum Dis , vol.69 , Issue.6 , pp. 995-1003
    • Schoels, M.1    Wong, J.2    Scott, D.L.3
  • 91
    • 79956333690 scopus 로고    scopus 로고
    • Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: A systematic review and economic evaluation
    • 21439251 1:STN:280:DC%2BC3MzgtlWkuw%3D%3D
    • Malottki K, Barton P, Tsourapas A, et al. Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: a systematic review and economic evaluation. Health Technol Assess. 2011;15(14):1-278.
    • (2011) Health Technol Assess , vol.15 , Issue.14 , pp. 1-278
    • Malottki, K.1    Barton, P.2    Tsourapas, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.