Downregulation of microRNA-206 is a potent prognostic marker for patients with gastric cancer

European Journal of Gastroenterology and Hepatology

Volumn 25, Issue 8, 2013, Pages 953-957

  Yang, Qi ^a   Zhang, Chao ^a   Huang, Bo ^a   Li, Huiyan ^a   Zhang, Rong ^a   Huang, Yuxin ^a   Wang, Jingjie ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gastric cancer; microRNA 206; prognosis; quantitative RT PCR

Indexed keywords

MICRORNA; MICRORNA 206; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GASTRECTOMY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH MUCOSA;

ADULT; AGED; AGED, 80 AND OVER; CHI-SQUARE DISTRIBUTION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MICRORNAS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84879974093     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32835ed691     Document Type: Article

References (20)

1. Martin L, Watanabe S, Fainsinger R, Lau F, Ghosh S, Quan H, et al. Prognostic factors in patients with advanced cancer: use of the patient-generated subjective global assessment in survival prediction. J Clin Oncol 2010; 28:4376-4383.
2. Ye YW, Dong RZ, Zhou Y, Du CY, Wang CM, Fu H, et al. Prognostic analysis of familial gastric cancer in Chinese population. J Surg Oncol 2011; 104:76-82.
3. Zhang YZ, Zhang LH, Gao Y, Li CH, Jia SQ, Liu N, et al. Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling. World JGastroenterol 2011; 17:1710-1717.
4. Bartel DP. Micro RNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
5. Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010; 466:835-840.
6. Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes Dev 2004; 18:504-511.
7. Esquela-Kerscher A, Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.
8. Link A, Kupcinskas J, Wex T, Malfertheiner P. Macro-role of microRNA in gastric cancer. Dig Dis 2012; 30:255-267.
9. Song MY, Pan KF, Su HJ, Zhang L, Ma JL, Li JY, et al. Identification of serum microRNAs as novel non-invasive biomarkers for early detection of gastric cancer. PLo S One 2012; 7:e 33608.
10. Adams BD, Cowee DM, White BA. The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells. Mol Endocrinol 2009; 23:1215-1230.
11. Chen X, Yan Q, Li S, Zhou L, Yang H, Yang Y, et al. Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma. Cancer Lett 2012; 314:41-53.
12. Macquarrie KL, Yao Z, Young JM, Cao Y, Tapscott SJ. miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells. Skelet Muscle 2012; 2:7.
13. Wang R, Hu Y, Song G, Hao CJ, Cui Y, Xia HF, et al. Mi R-206 regulates neural cells proliferation and apoptosis via Otx2. Cell Physiol Biochem 2012; 29:381-390.
14. Wang X, Ling C, Bai Y, Zhao J. Micro RNA-206 is associated with invasion and metastasis of lung cancer. Anat Rec (Hoboken) 2011; 294:88-92.
15. Zhang T, Liu M, Wang C, Lin C, Sun Y, Jin D. Down-regulation of miR-206 promotes proliferation and invasion of laryngeal cancer by regulating VEGF expression. Anticancer Res 2011; 31:3859-3863.
16. Sobin LH, Wittekind C. TNM classification ofmalignant tumours. 6th ed. New York: Wiley, International Union Against Cancer; 2002
17. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer 2011; 14:101-11 2.
18. Zhou W, Li Y, Wang X, Wu L, Wang Y Mi R-206-mediated dynamic mechanism of the mammalian circadian clock. BMC Syst Biol 2011; 5:141.
19. Dey BK, Gagan J, Dutta A. miR-206 and-486 induce myoblast differentiation by downregulating Pax7. Mol Cell Biol 2011; 31:203-214.
20. Song G, Wang L. Nuclear receptor SHP activates miR-206 expression via a cascade dual inhibitory mechanism. PLo S One 2009; 4:e 6880.