Effects of three therapeutic doses of codeine/paracetamol on driving performance, a psychomotor vigilance test, and subjective feelings

Psychopharmacology

Volumn 228, Issue 2, 2013, Pages 309-320

  Amato, Jean Noël ^a,b,d   Marie, Sullivan ^a,b   Lelong Boulouard, Véronique ^a,b,c   Paillet Loilier, Magalie ^c   Berthelon, Catherine ^d   Coquerel, Antoine ^a,b,c   Denise, Pierre ^a,b,c   Bocca, Marie Laure ^a,b  

^a NORMANDIE UNIVERSITÉ   (France)

^b INSERM U1075   (France)

^c CAEN UNIVERSITY HOSPITAL   (France)

^d UNIVERSITÉ GUSTAVE EIFFEL   (France)

Author keywords

Acute effects; Analgesics; Blood concentrations; Codeine; Dose effect relationships; Driving performance; Human; Psychomotor performance; Simulation; Young subjects

Indexed keywords

COCODAMOL; CODEINE; MORPHINE; PARACETAMOL; PLACEBO;

ADULT; ALERTNESS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRIVING ABILITY; DRUG BLOOD LEVEL; DRUG CONCENTRATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; MALE; MAXIMUM PLASMA CONCENTRATION; MORNING DOSAGE; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; VELOCITY; VISUAL ANALOG SCALE;

ACETAMINOPHEN; ADULT; AUTOMOBILE DRIVING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CODEINE; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMANS; MALE; PSYCHOMOTOR PERFORMANCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84879962482     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3035-7     Document Type: Article

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