Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11475-11480

  Harms, Michael J ^a   Eick, Geeta N ^a   Goswami, Devrishi ^b   Colucci, Jennifer K ^c   Griffin, Patrick R ^b   Ortlund, Eric A ^c   Thornton, Joseph W ^a,d  

^a UNIVERSITY OF OREGON   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Ancestral reconstruction; Evolutionary biochemistry; Molecular evolution; Protein evolution

Indexed keywords

ALANINE; ESTROGEN; STEROID RECEPTOR;

AMINO ACID ANALYSIS; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; EVOLUTION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PHYLOGENY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANCESTRAL RECONSTRUCTION; EVOLUTIONARY BIOCHEMISTRY; MOLECULAR EVOLUTION; PROTEIN EVOLUTION;

BIOPHYSICS; EVOLUTION, MOLECULAR; LIGANDS; MODELS, MOLECULAR; MUTATION; PHYLOGENY; PROTEIN BINDING; RECEPTORS, STEROID;

EID: 84879943516     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303930110     Document Type: Article

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