Expression profiling of lncRNAs in C3H10T1/2 mesenchymal stem cells undergoing early osteoblast differentiation

Molecular Medicine Reports

Volumn 8, Issue 2, 2013, Pages 463-467

  Zuo, Changqing ^a   Wang, Zonggui ^a,b,c   Lu, Hanyun ^a   Dai, Zhong ^a   Liu, Xinguang ^a,b,c   Cui, Liao ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b Departments of Biochemistry and Molecular Biology   (China)

^c Key Laboratory for Medical Molecular Diagnostics of Guangdong Province   (China)

Author keywords

Bioinformatics; Long non coding RNA; Mesenchymal stem cells; Osteoblast differentiation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; EPIDERMAL GROWTH FACTOR RECEPTOR; LONG UNTRANSLATED RNA;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; MESENCHYMAL STEM CELL; OSTEOBLAST; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; MESENCHYMAL STROMAL CELLS; MICE; OSTEOBLASTS; RNA, LONG NONCODING; TRANSCRIPTOME;

EID: 84879899789     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1540     Document Type: Article

References (25)

1. Wozney JM, Rosen V, Celeste AJ, et al: Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534, 1988.
2. Lin GL and Hankenson KD: Integration of BMP, Wnt and notch signaling pathways in osteoblast differentiation. J Cell Biochem 112: 3491-3501, 2011.
3. Huang J, Zhao L, Xing L and Chen D: MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28: 357-364, 2010.
4. Rosen V: BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev 20: 475-480, 2009.
5. Dong S, Yang B, Guo H and Kang F: MicroRNAs regulate osteogenesis and chondrogenesis. Biochem Biophys Res Commun 418: 587-591, 2012.
6. ENCODE Project Consortium; Birney E, Stamatoyannopoulos JA, Dutta A, et al: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447: 799-816, 2007.
7. Hung T and Chang HY: Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol 7: 582-585, 2010.
8. Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 23: 1494-1504, 2009.
9. Huarte M, Guttman M, Feldser D, et al: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142: 409-419, 2010.
10. Esteller M: Non-coding RNAs in human disease. Nat Rev Genet 12: 861-874, 2011.
11. Sui W, Li H, Ou M, Tang D and Dai Y: Altered long non-coding RNA expression profile in patients with IgA-negative mesangial proliferative glomerulonephritis. Int J Mol Med 30: 173-178, 2012.
12. Cesana M, Cacchiarelli D, Legnini I, et al: A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147: 358-369, 2011.
13. Kretz M, Siprashvili Z, Chu C, et al: Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature 493: 231-235, 2013.
14. Kretz M, Webster DE, Flockhart RJ, et al: Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev 26: 338-343, 2012.
15. Ng SY, Johnson R and Stanton LW: Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J 31: 522-533, 2011.
16. Wang KC and Chang HY: Molecular mechanisms of long noncoding RNAs. Mol Cell 43: 904-914, 2011.
17. Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell 136: 629-641, 2009.
18. Han L, Zhang K, Shi Z, et al: LncRNA profile of glioblastoma reveals the potential role of lncRNAs in contributing to glioblastoma pathogenesis. Int J Oncol 40: 2004-2012, 2012.
19. Chen D, Zhao M and Mundy GR: Bone morphogenetic proteins. Growth Factors 22: 233-241, 2004.
20. Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: insights into functions. Nat Rev Genet 10: 155-159, 2009.
21. Feng J, Bi C, Clark BS, Mady R, Shah P and Kohtz JD: The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev 20: 1470-1484, 2006.
22. Zhu J, Shimizu E, Zhang X, Partridge NC and Qin L: EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. J Cell Biochem 112: 1749-1760, 2011.
23. Abdallah BM, Ding M, Jensen CH, et al: Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology 148: 3111-3121, 2007.
24. Abdallah BM, Ditzel N, Mahmood A, et al: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. J Bone Miner Res 26: 1457-1471, 2011.
25. Macias MP, Fitzpatrick LA, Brenneise I, McGarry MP, Lee JJ and Lee NA: Expression of IL-5 alters bone metabolism and induces ossification of the spleen in transgenic mice. J Clin Invest 107: 949-959, 2001.