Synthesis, characterization and in vitro antimicrobial activity of some novel 5-substituted Schiff and Mannich base of isatin derivatives

Journal of Saudi Chemical Society

Volumn 17, Issue 3, 2013, Pages 337-344

  Prakash, Chinnasamy Rajaram ^a   Raja, Sundararajan ^b  

^a JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^b GITAM UNIVERSITY   (India)

Author keywords

Antimicrobial activity; Indolin 2 one; Mannich base; Schiff base

Indexed keywords

EID: 84879890930     PISSN: 13196103     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jscs.2011.10.022     Document Type: Article

References (16)

1. Amalraj A., Raghunathan R., SrideviKumari M.R., Raman N. Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines. Bioorg. Med. Chem. 2003, 11:407-419.
2. Charifson P.S., Grillot A.L., Grossman T.H., Parsons J.D., Badia M., Bellon S., Deininger D.D., Drumm J.E., Gross C.H., LeTiran A., Liao Y.S., Mani N., Nicolau D.P., Perola E., Ronkin S., Shannon D., Swenson L.L., Tang Q., Tessier P.R., Tian S.K., Trudeau M., Wang T.S., Wei Y.Y., Zhang H., Stamos D. Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. J. Med. Chem. 2008, 51:5243-5263.
3. Emmerson A.M., Jones A.M. The quinolone: decades of development and use. J. Antimicrob. Chemother. 2003, 51:13-20.
4. Feng L.S., Liu M.L., Wang B., Chai Y., Hao X.Q., Meng S., Guo H.Y. Synthesis and in vitro antimycobacterial activity of Balofloxacin ethylene isatin derivatives. Eur. J. Med. Chem. 2010, 45:3407-3412.
5. Gillespie S.H. Medical Microbiology-Illustrated 1994, Butterworth Heinemann Ltd., United Kingdom, pp. 234-247.
6. Hawkey P.M., Lewis D.A. Medical Bacteriology - a Practical Approach 1994, Oxford University Press, United Kingdom, pp. 181-194.
7. Kandile N.G., Zaky H.T., Mohamed M.I., Ismaeel H.M., Ahmed N.A. Synthesis, characterization and in vitro antimicrobial evaluation of new compounds incorporating oxindole nucleus. J. Enz. Inh. Med. Chem. 2011, 1-10.
8. Koca M., Servi S., Kirilmis C., Ahmedzade M., Kazaz C., Ozbek B., Otuk G. Synthesis and antimicrobial activity of (benzofuran-2-yl) (3-phenyl-3-methylcyclobutyl) ketoxime derivatives. Eur. J. Med. Chem. 2005, 40:1351-1358.
9. 3ciprofloxacin methylene and ethylene isatin derivatives. Eur. J. Med. Chem. 2011, 46:341-348.
10. Lian-Shun F., Ming-Liang L., Bo W., Yun C., Xue-Qin H., Shuai M., Hui-Yuan G. Synthesis and in vitro antimycobacterial activity of Balofloxacin ethylene isatin derivatives. Eur. J. Med. Chem. 2010, 45:3407-3412.
11. Miller J.P., Stoodley R.J. The use of D-glucose-based silyloxy dienes in anthracyclinone synthesis. J. Saudi Chem. Soc. 2011, 15:275-281.
12. Pandeya S.N., Smitha S., Jyoti M., Sridhar S.K. Biological activities of isatin and its derivatives. Acta Pharm. 2005, 55:27-46.
13. Praveen C., Ayyanar A., Perumal P.T. Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di (indolyl)indolin-2-ones. Bioorg. Med. Chem. Lett. 2011, 21:4072-4077.
14. Sriram D., Aubry A., Yogeeswari P., Fisher L.M. Gatifloxacin derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase. Bioorg. Med. Chem. Lett. 2006, 16:2982-2985.
15. Sriram D., Yogeeswari P., Basha J.S., Radha D.R., Nagaraja V.J. Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives. Bioorg. Med. Chem. 2005, 13:5774-5778.
16. Yu D., Huiyuan G. Synthesis and antibacterial activity of Linezolid analogues. Bioorg. Med. Chem. Lett. 2002, 12:857-859.