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Volumn 25, Issue 4, 2013, Pages 417-424

Esophageal carcinoma: Are modern targeted therapies shaking the rock?

Author keywords

cancer; esophagogastric junction; esophagus; human epidermal growth factor receptor 2; targeted therapy

Indexed keywords

AFATINIB; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ERLOTINIB; EVEROLIMUS; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MATUZUMAB; OXALIPLATIN; PACLITAXEL; PLACEBO; PLATINUM; RAMUCIRUMAB; SOMATOMEDIN C RECEPTOR; SUNITINIB; TRASTUZUMAB; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN;

EID: 84879884170     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328362105e     Document Type: Review
Times cited : (10)

References (86)
  • 2
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D, Starling N, Rao S, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med 2008; 358:36-46.
    • (2008) N Engl J Med , vol.358 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 3
    • 84879879588 scopus 로고    scopus 로고
    • SEER: Survival Epidemiology and End Results Database. Bethesda, MD. [Accessed 27 September 2012]
    • SEER: Survival Epidemiology and End Results Database. Bethesda, MD. http://seer.cancer.gov/statfacts/html/esoph.html. [Accessed 27 September 2012]
  • 4
    • 34247552263 scopus 로고    scopus 로고
    • An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus
    • DOI 10.1097/01.sla.0000251703.35919.02, PII 0000065820070500000009
    • Wijnhoven BP, Tran KT, Esterman A, et al. An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus. Ann Surg 2007; 245:717-725. (Pubitemid 46684101)
    • (2007) Annals of Surgery , vol.245 , Issue.5 , pp. 717-725
    • Wijnhoven, B.P.L.1    Tran, K.T.C.2    Esterman, A.3    Watson, D.I.4    Tilanus, H.W.5
  • 5
    • 78349233141 scopus 로고    scopus 로고
    • Surgical management of submucosal esophageal cancer: Extended or regional lymphadenectomy?
    • Grotenhuis BA, van Heijl M, Zehetner J, et al. Surgical management of submucosal esophageal cancer: extended or regional lymphadenectomy? Ann Surg 2010; 252:823-830.
    • (2010) Ann Surg , vol.252 , pp. 823-830
    • Grotenhuis, B.A.1    Van Heijl, M.2    Zehetner, J.3
  • 11
    • 69249123371 scopus 로고    scopus 로고
    • Targets for molecular therapy in esophageal squamous cell carcinoma: An immunohistochemical analysis
    • Boone J, van Hillegersberg R, Offerhaus GJ, et al. Targets for molecular therapy in esophageal squamous cell carcinoma: an immunohistochemical analysis. Dis Esophagus 2009; 22:496-504.
    • (2009) Dis Esophagus , vol.22 , pp. 496-504
    • Boone, J.1    Van Hillegersberg, R.2    Offerhaus, G.J.3
  • 12
    • 84859024264 scopus 로고    scopus 로고
    • Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma
    • Bandla S, Pennathur A, Luketich JD, et al. Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. Ann Thorac Surg 2012; 93:1101-1106.
    • (2012) Ann Thorac Surg , vol.93 , pp. 1101-1106
    • Bandla, S.1    Pennathur, A.2    Luketich, J.D.3
  • 14
    • 0346963103 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy
    • Gibson MK, Abraham SC, Wu TT, et al. Epidermal growth factor receptor, p53 mutation, and pathological response predict survival in patients with locally advanced esophageal cancer treated with preoperative chemoradiotherapy. Clin Cancer Res 2003; 9:6461-6468. (Pubitemid 38031834)
    • (2003) Clinical Cancer Research , vol.9 , Issue.17 , pp. 6461-6468
    • Gibson, M.K.1    Abraham, S.C.2    Wu, T.-T.3    Burtness, B.4    Heitmiller, R.F.5    Heath, E.6    Forastiere, A.7
  • 17
    • 84855799452 scopus 로고    scopus 로고
    • Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction
    • Wang WP, Wang KN, Gao Q, Chen LQ. Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction. World J Surg Oncol 2012; 10:14.
    • (2012) World J Surg Oncol , vol.10 , pp. 14
    • Wang, W.P.1    Wang, K.N.2    Gao, Q.3    Chen, L.Q.4
  • 18
    • 84866733910 scopus 로고    scopus 로고
    • A phase II trial of gefitinib for recurrent or metastatic cancer of the esophagus or gastroesophageal junction
    • Adelstein DJ, Rodriguez CP, Rybicki LA, et al. A phase II trial of gefitinib for recurrent or metastatic cancer of the esophagus or gastroesophageal junction. Invest New Drugs 2012; 30:1684-1689.
    • (2012) Invest New Drugs , vol.30 , pp. 1684-1689
    • Adelstein, D.J.1    Rodriguez, C.P.2    Rybicki, L.A.3
  • 20
    • 79952847624 scopus 로고    scopus 로고
    • A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus
    • Ilson DH, Kelsen D, Shah M, et al. A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus. Cancer 2011; 117:1409-1414.
    • (2011) Cancer , vol.117 , pp. 1409-1414
    • Ilson, D.H.1    Kelsen, D.2    Shah, M.3
  • 22
    • 80052439302 scopus 로고    scopus 로고
    • Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
    • Wainberg ZA, Lin LS, DiCarlo B, et al. Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction. Br J Cancer 2011; 105:760-765.
    • (2011) Br J Cancer , vol.105 , pp. 760-765
    • Wainberg, Z.A.1    Lin, L.S.2    Dicarlo, B.3
  • 23
    • 84889942410 scopus 로고    scopus 로고
    • Phase II study of neoadjuvant and adjuvant gefitinib (G) with neoadjuvant chemoradiotherapy (CRT) in operable esophageal adenocarcinoma (EAC) [abstract]
    • abstr e14532
    • Juergens RA, Gibson MK, Yang SC, et al. Phase II study of neoadjuvant and adjuvant gefitinib (G) with neoadjuvant chemoradiotherapy (CRT) in operable esophageal adenocarcinoma (EAC) [abstract]. J Clin Oncol 2010; 28:. (suppl; abstr e14532).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Juergens, R.A.1    Gibson, M.K.2    Yang, S.C.3
  • 24
    • 78549279090 scopus 로고    scopus 로고
    • Phase II study of concurrent chemoradiation in combination with erlotinib for locally advanced esophageal carcinoma
    • Li G, Hu W, Wang J, et al. Phase II study of concurrent chemoradiation in combination with erlotinib for locally advanced esophageal carcinoma. Int J Radiat Oncol Biol Phys 2010; 78:1407-1412.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , pp. 1407-1412
    • Li, G.1    Hu, W.2    Wang, J.3
  • 25
    • 79957834501 scopus 로고    scopus 로고
    • A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma
    • Chan JA, Blaszkowsky LS, Enzinger PC, et al. A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma. Ann Oncol 2011; 22:1367-1373.
    • (2011) Ann Oncol , vol.22 , pp. 1367-1373
    • Chan, J.A.1    Blaszkowsky, L.S.2    Enzinger, P.C.3
  • 26
    • 82755167862 scopus 로고    scopus 로고
    • Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5- fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: Results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Luber B, Deplazes J, Keller G, et al. Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO). BMC Cancer 2011; 11:509.
    • (2011) BMC Cancer , vol.11 , pp. 509
    • Luber, B.1    Deplazes, J.2    Keller, G.3
  • 27
    • 79951532484 scopus 로고    scopus 로고
    • CALGB 80403/ECOG 1206: A randomized phase II study of three standard chemotherapy regimens (ECF, IC, FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer
    • Enzinger PC, Burtness B, Hollis D, et al. CALGB 80403/ECOG 1206: A randomized phase II study of three standard chemotherapy regimens (ECF, IC, FOLFOX) plus cetuximab in metastatic esophageal and GE junction cancer. J Clin Oncol 2010; 28 (suppl 4006).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 4006
    • Enzinger, P.C.1    Burtness, B.2    Hollis, D.3
  • 28
    • 77958496605 scopus 로고    scopus 로고
    • Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: A randomised, multicentre open-label phase II study
    • Rao S, Starling N, Cunningham D, et al. Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: a randomised, multicentre open-label phase II study. Ann Oncol 2010; 21:2213-2219.
    • (2010) Ann Oncol , vol.21 , pp. 2213-2219
    • Rao, S.1    Starling, N.2    Cunningham, D.3
  • 29
    • 84868295867 scopus 로고    scopus 로고
    • A randomized multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3) [abstract]
    • Waddell TS, Chau I, Barbachano Y, et al. A randomized multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3) [abstract]. J Clin Oncol 2012; 30:. (suppl; LBA4000).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Waddell, T.S.1    Chau, I.2    Barbachano, Y.3
  • 30
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • Douillard JY, Siena S, Cassidy J, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010; 28:4697-4705.
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 31
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatinbased first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, et al. Addition of cetuximab to oxaliplatinbased first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011; 377:2103-2114.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 32
    • 77957549871 scopus 로고    scopus 로고
    • Drug development in advanced esophagogastric cancer: The art of extrapolation
    • Punt CJ. Drug development in advanced esophagogastric cancer: the art of extrapolation. J Clin Oncol 2010; 28:3907-3909.
    • (2010) J Clin Oncol , vol.28 , pp. 3907-3909
    • Punt, C.J.1
  • 33
    • 77957552916 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: Dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial
    • Okines AF, Ashley SE, Cunningham D, et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-finding study for the prospective multicenter, randomized, phase II/III REAL-3 trial. J Clin Oncol 2010; 28:3945-3950.
    • (2010) J Clin Oncol , vol.28 , pp. 3945-3950
    • Okines, A.F.1    Ashley, S.E.2    Cunningham, D.3
  • 34
    • 84862143612 scopus 로고    scopus 로고
    • Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: A phase-II study of the SWOG (S0414)
    • Tomblyn MB, Goldman BH, Thomas CR Jr, et al. Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414). J Thorac Oncol 2012; 7:906-912.
    • (2012) J Thorac Oncol , vol.7 , pp. 906-912
    • Tomblyn, M.B.1    Goldman, B.H.2    Thomas Jr., C.R.3
  • 35
    • 79551583770 scopus 로고    scopus 로고
    • A multicenter phase II study of induction chemotherapy with FOLFOX-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer
    • De Vita F, Orditura M, Martinelli E, et al. A multicenter phase II study of induction chemotherapy with FOLFOX-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer. Br J Cancer 2011; 104:427-432.
    • (2011) Br J Cancer , vol.104 , pp. 427-432
    • De Vita, F.1    Orditura, M.2    Martinelli, E.3
  • 36
    • 85047688466 scopus 로고    scopus 로고
    • Treatment of malignant, nonresectable, epithelial origin esophageal tumours with the humanized antiepidermal growth factor antibody nimotuzumab combined with radiation therapy and chemotherapy
    • Ramos-Suzarte M, Lorenzo-Luaces P, Lazo NG, et al. Treatment of malignant, nonresectable, epithelial origin esophageal tumours with the humanized antiepidermal growth factor antibody nimotuzumab combined with radiation therapy and chemotherapy. Cancer Biol Ther 2012; 13:600-605.
    • (2012) Cancer Biol Ther , vol.13 , pp. 600-605
    • Ramos-Suzarte, M.1    Lorenzo-Luaces, P.2    Lazo, N.G.3
  • 37
    • 80755136188 scopus 로고    scopus 로고
    • Chemoradiation with FOLFOX plus cetuximab in locally advanced cardia or esophageal cancer: Final results of a GERCOR phase II trial (ERaFOX) [abstract]
    • Lledo G, Michel P, Dahan L, et al. Chemoradiation with FOLFOX plus cetuximab in locally advanced cardia or esophageal cancer: Final results of a GERCOR phase II trial (ERaFOX) [abstract]. J Clin Oncol 2011; 29 ((suppl 4; 8)).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4 , pp. 8
    • Lledo, G.1    Michel, P.2    Dahan, L.3
  • 38
    • 80052151082 scopus 로고    scopus 로고
    • E2205: A phase II study to measure response rate and toxicity of neoadjuvant chemoradiotherapy (CRT) with oxaliplatin (OX) and infusional 5-fluorouracil (5-FU) plus cetuximab (C) followed by postoperative docetaxel (DT) and C in patients with operable adenocarcinoma of the esophagus [abstract]
    • (suppl; 4064)
    • Gibson MK, Catalano PJ, Kleinberg L, et al. E2205: A phase II study to measure response rate and toxicity of neoadjuvant chemoradiotherapy (CRT) with oxaliplatin (OX) and infusional 5-fluorouracil (5-FU) plus cetuximab (C) followed by postoperative docetaxel (DT) and C in patients with operable adenocarcinoma of the esophagus [abstract]. J Clin Oncol 28:15s, 2010 (suppl; 4064).
    • (2010) J Clin Oncol , vol.28 , Issue.15 S
    • Gibson, M.K.1    Catalano, P.J.2    Kleinberg, L.3
  • 39
    • 79961021036 scopus 로고    scopus 로고
    • An open label, multicenter clinical study of cetuximab combined with concurrent chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: Preliminary results of a phase II trial [abstract]
    • Yu JM, Wang JH, Sun X, et al. An open label, multicenter clinical study of cetuximab combined with concurrent chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: Preliminary results of a phase II trial [abstract]. J Clin Oncol 2010; 28: (suppl; e14520).
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Yu, J.M.1    Wang, J.H.2    Sun, X.3
  • 40
    • 3343003869 scopus 로고    scopus 로고
    • Ethical implications of pharmacogenetics - Do slippery slope arguments matter?
    • Schubert L. Ethical implications of pharmacogenetics-do slippery slope arguments matter? Bioethics 2004; 18:361-378. (Pubitemid 38992318)
    • (2004) Bioethics , vol.18 , Issue.4 , pp. 361-378
    • Schubert, L.1
  • 42
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235:177-182. (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 43
    • 3042622482 scopus 로고    scopus 로고
    • HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues
    • Owens MA, Horten BC, Da Silva MM. HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues. Clin Breast Cancer 2004; 5:63-69. (Pubitemid 38821193)
    • (2004) Clinical Breast Cancer , vol.5 , Issue.1 , pp. 63-69
    • Owens, M.A.1    Horten, B.C.2    Da Silva, M.M.3
  • 44
    • 80053018463 scopus 로고    scopus 로고
    • HER2 testing in gastric/gastroesophageal junction adenocarcinomas: Unique features of a familiar test
    • Ross JS, Mulcahy M. HER2 testing in gastric/gastroesophageal junction adenocarcinomas: unique features of a familiar test. Gastrointest Cancer Res 2011; 4:62-66.
    • (2011) Gastrointest Cancer Res , vol.4 , pp. 62-66
    • Ross, J.S.1    Mulcahy, M.2
  • 45
    • 50849123421 scopus 로고    scopus 로고
    • HER2 in gastric cancer: A new prognostic factor and a novel therapeutic target
    • Gravalos C, Jimeno A. HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol 2008; 19:1523-1529.
    • (2008) Ann Oncol , vol.19 , pp. 1523-1529
    • Gravalos, C.1    Jimeno, A.2
  • 46
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2- positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2- positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010; 376:687-697.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 48
    • 84867131579 scopus 로고    scopus 로고
    • Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: A European and USA International collaborative analysis
    • Janjigian YY, Werner D, Pauligk C, et al. Prognosis of metastatic gastric and gastroesophageal junction cancer by HER2 status: a European and USA International collaborative analysis. Ann Oncol 2012; 23:2656-2662.
    • (2012) Ann Oncol , vol.23 , pp. 2656-2662
    • Janjigian, Y.Y.1    Werner, D.2    Pauligk, C.3
  • 49
    • 84868630658 scopus 로고    scopus 로고
    • HER2 as a prognostic marker in gastric cancer - A systematic analysis of data from the literature
    • Jorgensen JT, Hersom M. HER2 as a prognostic marker in gastric cancer-a systematic analysis of data from the literature. J Cancer 2012; 3:137-144.
    • (2012) J Cancer , vol.3 , pp. 137-144
    • Jorgensen, J.T.1    Hersom, M.2
  • 50
    • 82555194531 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 testing in gastroesophageal cancer: Correlation between immunohistochemistry and fluorescence in situ hybridization
    • Tafe LJ, Janjigian YY, Zaidinski M, et al. Human epidermal growth factor receptor 2 testing in gastroesophageal cancer: correlation between immunohistochemistry and fluorescence in situ hybridization. Arch Pathol Lab Med 2011; 135:1460-1465.
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 1460-1465
    • Tafe, L.J.1    Janjigian, Y.Y.2    Zaidinski, M.3
  • 51
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A german breast group 26/breast international group 03-05 study
    • von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a german breast group 26/breast international group 03-05 study. J Clin Oncol 2009; 27:1999-2006.
    • (2009) J Clin Oncol , vol.27 , pp. 1999-2006
    • Von Minckwitz, G.1    Du Bois, A.2    Schmidt, M.3
  • 52
    • 77953453066 scopus 로고    scopus 로고
    • Lapatinib monotherapy in recurrent upper gastrointestinal malignancy: Phase II efficacy and biomarker analyses
    • Hecht JR, Urba SG, Koehler M, et al. Lapatinib monotherapy in recurrent upper gastrointestinal malignancy: Phase II efficacy and biomarker analyses. 2008 Gastrointestinal Cancers Symposium.
    • (2008) Gastrointestinal Cancers Symposium
    • Hecht, J.R.1    Urba, S.G.2    Koehler, M.3
  • 53
    • 84861184026 scopus 로고    scopus 로고
    • A global, multicenter phase II trial of lapatinib plus capecitabine in gastric cancer [abstract]
    • Pishvaian M, Sakaeva D, Hsieh RK, et al. A global, multicenter phase II trial of lapatinib plus capecitabine in gastric cancer [abstract]. J Clin Oncol 2011; 29 (suppl 4; 88).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4 , pp. 88
    • Pishvaian, M.1    Sakaeva, D.2    Hsieh, R.K.3
  • 55
    • 79959621928 scopus 로고    scopus 로고
    • Targeting angiogenesis in esophagogastric adenocarcinoma
    • Okines AF, Reynolds AR, Cunningham D. Targeting angiogenesis in esophagogastric adenocarcinoma. Oncologist 2011; 16:844-858.
    • (2011) Oncologist , vol.16 , pp. 844-858
    • Okines, A.F.1    Reynolds, A.R.2    Cunningham, D.3
  • 56
    • 67649300463 scopus 로고    scopus 로고
    • The clinicopathological significance of tissue levels of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in gastric cancer
    • Kim SE, Shim KN, Jung SA, et al. The clinicopathological significance of tissue levels of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in gastric cancer. Gut Liver 2009; 3:88-94.
    • (2009) Gut Liver , vol.3 , pp. 88-94
    • Kim, S.E.1    Shim, K.N.2    Jung, S.A.3
  • 58
    • 80053573446 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A randomized, double-blind, placebo-controlled phase III study
    • Ohtsu A, Shah MA, Van Cutsem E, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol 2011; 29:3968-3976.
    • (2011) J Clin Oncol , vol.29 , pp. 3968-3976
    • Ohtsu, A.1    Shah, M.A.2    Van Cutsem, E.3
  • 59
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
    • Van Cutsem E, de Haas S, Kang YK, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 2012; 30:2119-2127.
    • (2012) J Clin Oncol , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1    De Haas, S.2    Kang, Y.K.3
  • 60
    • 77649213706 scopus 로고    scopus 로고
    • Phase i pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor- 2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor- 2. J Clin Oncol 2010; 28:780-787.
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 61
    • 82955241985 scopus 로고    scopus 로고
    • Phase II study of sunitinib as second-line treatment for advanced gastric cancer
    • Bang YJ, Kang YK, Kang WK, et al. Phase II study of sunitinib as second-line treatment for advanced gastric cancer. Invest New Drugs 2011; 29:1449-1458.
    • (2011) Invest New Drugs , vol.29 , pp. 1449-1458
    • Bang, Y.J.1    Kang, Y.K.2    Kang, W.K.3
  • 62
    • 84863364424 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel in patients with advanced esophageal cancer: A phase II study from the Hoosier Oncology Group
    • Schmitt JM, Sommers SR, Fisher W, et al. Sunitinib plus paclitaxel in patients with advanced esophageal cancer: a phase II study from the Hoosier Oncology Group. J Thorac Oncol 2012; 7:760-763.
    • (2012) J Thorac Oncol , vol.7 , pp. 760-763
    • Schmitt, J.M.1    Sommers, S.R.2    Fisher, W.3
  • 63
    • 77954574658 scopus 로고    scopus 로고
    • Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
    • Sun W, Powell M, O'Dwyer PJ, et al. Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J Clin Oncol 2010; 28:2947-2951.
    • (2010) J Clin Oncol , vol.28 , pp. 2947-2951
    • Sun, W.1    Powell, M.2    O'dwyer, P.J.3
  • 64
    • 84874416396 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab, irinotecan, cisplatin, and radiation as preoperative therapy in esophageal adenocarcinoma [abstract]
    • Ilson D, Goodman KA, Janjigian YY, et al. Phase II trial of bevacizumab, irinotecan, cisplatin, and radiation as preoperative therapy in esophageal adenocarcinoma [abstract]. J Clin Oncol 2012; 30(suppl 4; 67).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 4 , pp. 67
    • Ilson, D.1    Goodman, K.A.2    Janjigian, Y.Y.3
  • 65
    • 84864390180 scopus 로고    scopus 로고
    • A phase II trial of preoperative concurrent chemotherapy/radiation therapy plus bevacizumab/erlotinib in the treatment of localized esophageal cancer
    • Bendell JC, Meluch A, Peyton J, et al. A phase II trial of preoperative concurrent chemotherapy/radiation therapy plus bevacizumab/erlotinib in the treatment of localized esophageal cancer. Clin Adv Hematol Oncol 2012; 10:430-437.
    • (2012) Clin Adv Hematol Oncol , vol.10 , pp. 430-437
    • Bendell, J.C.1    Meluch, A.2    Peyton, J.3
  • 66
    • 84887020952 scopus 로고    scopus 로고
    • A phase i evaluation of vandetanib plus paclitaxel, carboplatin, 5-fluorouracil, and XRT induction therapy followed by surgery for previously untreated locally advanced cancer of the esophagus and GE junction [abstract]
    • Astsaturov IA, Meyer JE, Cheng JD, et al. A phase I evaluation of vandetanib plus paclitaxel, carboplatin, 5-fluorouracil, and XRT induction therapy followed by surgery for previously untreated locally advanced cancer of the esophagus and GE junction [abstract]. J Clin Oncol 2012; 30(suppl 4; 74).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 4 , pp. 74
    • Astsaturov, I.A.1    Meyer, J.E.2    Cheng, J.D.3
  • 67
    • 84857789861 scopus 로고    scopus 로고
    • Aberrant activation of the mTOR pathway and antitumour effect of everolimus on oesophageal squamous cell carcinoma
    • Hirashima K, Baba Y, Watanabe M, et al. Aberrant activation of the mTOR pathway and antitumour effect of everolimus on oesophageal squamous cell carcinoma. Br J Cancer 2012; 106:876-882.
    • (2012) Br J Cancer , vol.106 , pp. 876-882
    • Hirashima, K.1    Baba, Y.2    Watanabe, M.3
  • 68
    • 84887022761 scopus 로고    scopus 로고
    • Clinicopathologic significance and function of mammalian target of rapamycin activation in esophageal squamous cell carcinoma
    • Kim SH, Chau GC, Jang YH, et al. Clinicopathologic significance and function of mammalian target of rapamycin activation in esophageal squamous cell carcinoma. Hum Pathol 2012.
    • (2012) Hum Pathol
    • Kim, S.H.1    Chau, G.C.2    Jang, Y.H.3
  • 69
    • 84861392332 scopus 로고    scopus 로고
    • Phase III trial of everolimus (EVE) in previously treated patients with advanced gastric cancer (AGC): GRANITE-1 [abstract]
    • Van Cutsem E, Yeh KH, Bang YJ, et al. Phase III trial of everolimus (EVE) in previously treated patients with advanced gastric cancer (AGC): GRANITE-1 [abstract]. J Clin Oncol 2012; 30(suppl 4; LBA3).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 4
    • Van Cutsem, E.1    Yeh, K.H.2    Bang, Y.J.3
  • 70
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011; 29:3126-3132.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 71
    • 84997941720 scopus 로고    scopus 로고
    • An overview of the c-MET signaling pathway
    • Organ SL, Tsao MS. An overview of the c-MET signaling pathway. Ther Adv Med Oncol 2011; 3 (Suppl 1):S7-S19.
    • (2011) Ther Adv Med Oncol , vol.3 , Issue.SUPPL. 1
    • Organ, S.L.1    Tsao, M.S.2
  • 73
    • 40849119954 scopus 로고    scopus 로고
    • Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma
    • DOI 10.1038/sj.bjc.6604251, PII 6604251
    • Tuynman JB, Lagarde SM, Ten Kate FJ, et al. Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma. Br J Cancer 2008; 98:1102-1108. (Pubitemid 351399800)
    • (2008) British Journal of Cancer , vol.98 , Issue.6 , pp. 1102-1108
    • Tuynman, J.B.1    Lagarde, S.M.2    Ten Kate, F.J.W.3    Richel, D.J.4    Van Lanschot, J.J.B.5
  • 74
    • 0035175805 scopus 로고    scopus 로고
    • Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESVV) using human cancer cDNA arrays: Overexpression of oncogene MET correlates with tumor differentiation in ESCC
    • Hu YC, Lam KY, Law S, et al. Profiling of differentially expressed cancerrelated genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC. Clin Cancer Res 2001; 7:3519-3525. (Pubitemid 33069989)
    • (2001) Clinical Cancer Research , vol.7 , Issue.11 , pp. 3519-3525
    • Hu, Y.C.1    Lam, K.Y.2    Law, S.3    Wong, J.4    Srivastava, G.5
  • 75
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol 2011; 29:4803-4810.
    • (2011) J Clin Oncol , vol.29 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 76
    • 84870511276 scopus 로고    scopus 로고
    • Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer [abstract]
    • Oliner KS, Tang R, Anderson A, et al. Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer [abstract]. J Clin Oncol 2012; 30(suppl; 4005).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 4005
    • Oliner, K.S.1    Tang, R.2    Anderson, A.3
  • 78
    • 35148889523 scopus 로고    scopus 로고
    • A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
    • June 20 (No 18S, 3505)
    • Higano CS, Yu EY, Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncol 2007; (June 20 Supplement); 27(No 18S, 3505).
    • (2007) J Clin Oncol , Issue.SUPPL. 27
    • Higano, C.S.1    Yu, E.Y.2    Whiting, S.H.3
  • 79
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'day, S.J.2    McDermott, D.F.3
  • 80
    • 77649136167 scopus 로고    scopus 로고
    • Modulation of lymphocyte regulation for cancer therapy: A phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma
    • Ralph C, Elkord E, Burt DJ, et al. Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clin Cancer Res 2010; 16:1662-1672.
    • (2010) Clin Cancer Res , vol.16 , pp. 1662-1672
    • Ralph, C.1    Elkord, E.2    Burt, D.J.3
  • 83
    • 48249135539 scopus 로고    scopus 로고
    • Patients with ERCC1-negative locally advanced esophageal cancers may benefit from preoperative chemoradiotherapy
    • Kim MK, Cho KJ, Kwon GY, et al. Patients with ERCC1-negative locally advanced esophageal cancers may benefit from preoperative chemoradiotherapy. Clin Cancer Res 2008; 14:4225-4231.
    • (2008) Clin Cancer Res , vol.14 , pp. 4225-4231
    • Kim, M.K.1    Cho, K.J.2    Kwon, G.Y.3
  • 84
    • 84855351500 scopus 로고    scopus 로고
    • Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis
    • Metzger R, Warnecke-Eberz U, Alakus H, et al. Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis. J Gastrointest Surg 2012; 16:26-34.
    • (2012) J Gastrointest Surg , vol.16 , pp. 26-34
    • Metzger, R.1    Warnecke-Eberz, U.2    Alakus, H.3
  • 85
    • 79955979832 scopus 로고    scopus 로고
    • Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: A retrospective cohort study of the Eastern Cooperative Oncology Group
    • Yoon HH, Catalano PJ, Murphy KM, et al. Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group. BMC Cancer 2011; 11:176.
    • (2011) BMC Cancer , vol.11 , pp. 176
    • Yoon, H.H.1    Catalano, P.J.2    Murphy, K.M.3
  • 86
    • 67650388521 scopus 로고    scopus 로고
    • Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer
    • Burtness B, Gibson M, Egleston B, et al. Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer. Ann Oncol 2009; 20:1242-1248.
    • (2009) Ann Oncol , vol.20 , pp. 1242-1248
    • Burtness, B.1    Gibson, M.2    Egleston, B.3


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