Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome

AIDS

Volumn 27, Issue 11, 2013, Pages 1725-1734

  Tran, Huyen T T ^a,b   Van Den Bergh, Rafael ^a,b   Loembé, Marguerite M ^c   Worodria, William ^d   Mayanja Kizza, Harriet ^d   Colebunders, Robert ^c,e   Mascart, Françoise ^f   Stordeur, Patrick ^g   Kestens, Luc ^c,e   De Baetselier, Patrick ^a,b   Raes, Geert ^a,b  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d MAKERERE UNIVERSITY   (Uganda)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^g ERASME HOSPITAL   (Belgium)

Author keywords

combined antiretroviral therapy; complement system; HIV tuberculosis co infection; immune reconstitution inflammatory syndrome; monocytes

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C5;

ARTICLE; CD4 LYMPHOCYTE COUNT; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNOMODULATION; METABOLISM; MONOCYTE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; TUBERCULOSIS; TUBERCULOSIS ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME;

ADULT; ANTI-HIV AGENTS; COINFECTION; COMPLEMENT SYSTEM PROTEINS; FEMALE; GENE EXPRESSION PROFILING; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MALE; MONOCYTES; PROSPECTIVE STUDIES; TUBERCULOSIS;

EID: 84879878240     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328361648b     Document Type: Article

References (28)

1. Lawn SD, Bekker LG, Miller RF. Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infect Dis 2005; 5:361-373.
2. Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, et al. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 2008; 8:516-523.
3. Worodria W, Massinga-Loembe M, Mazakpwe D, Luzinda K, Menten J, Van Leth F, et al. Incidence and predictors of mortality and the effect of tuberculosis immune reconstitution inflammatory syndrome in a cohort of TB/HIV patients commencing antiretroviral therapy. J Acquir Immune Defic Syndr 2011; 58:32-37.
4. Conradie F, Foulkes AS, Ive P, Yin X, Roussos K, Glencross DK, et al. Natural killer cell activation distinguishes Mycobacterium tuberculosis-mediated immune reconstitution syndrome from chronic HIV and HIV/MTB coinfection. J Acquir Immune Defic Syndr 2011; 58:309-318.
5. Pean P, Nerrienet E, Madec Y, Borand L, Laureillard D, Fernandez M, et al. Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis. Blood 2012; 119:3315-3320.
6. Van den Bergh R, Vanham G, Raes G, De Baetselier P, Colebunders R. Mycobacterium-associated immune reconstitution disease: macrophages running wild? Lancet Infect Dis 2006; 6:2-3; author reply 4-5.
7. Lawn SD, Wainwright H, Orrell C. Fatal unmasking tuberculosis immune reconstitution disease with bronchiolitis obliterans organizing pneumonia: the role of macrophages. AIDS 2009; 23:143-145.
8. Worodria W, Menten J, Massinga-Loembe M, Mazakpwe D, Bagenda D, Koole O, et al. Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection. Antivir Ther 2012; 17:841-848.
9. Smyth G. Limma: linear models for microarray data. New York: Springer; 2005.
10. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3:Article 3 [Epub 12 February 2004].
11. Benjamini YHY. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57:289-300.
12. Nuijens JH, Eerenberg-Belmer AJ, Huijbregts CC, Schreuder WO, Felt-Bersma RJ, Abbink JJ, et al. Proteolytic inactivation of plasma C1-inhibitor in sepsis. J Clin Invest 1989; 84:443-450.
13. Curd JG, Yelvington M, Ziccardi RJ, Mathison DA, Griffin JH. Purification and characterization of two functionally distinct forms of C1 inhibitor from a patient with angioedema. Clin Exp Immunol 1981; 45:261-270.
14. Bourgarit A, Carcelain G, Samri A, Parizot C, Lafaurie M, Abgrall S, et al. Tuberculosis-associated immune restoration syndrome in HIV-1-infected patients involves tuberculinspecific CD4 Th1 cells and KIR-negative gammadelta T cells. J Immunol 2009; 183:3915-3923.
15. Meintjes G, Wilkinson KA, Rangaka MX, Skolimowska K, van Veen K, Abrahams M, et al. Type 1 helper T cells and FoxP3- positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med 2008; 178:1083-1089.
16. Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, et al. Elevated frequencies of highly activated CD4R T cells in HIVR patients developing immune reconstitution inflammatory syndrome. Blood 2010; 116:3818-3827.
17. Reid KB, Porter RR. The proteolytic activation systems of complement. Annu Rev Biochem 1981; 50:433-464.
18. Fearon DT, Carroll MC. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu Rev Immunol 2000; 18:393-422.
19. Barton GM, Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 2002; 14:380-383.
20. Mizuno M, Cole DS. Novel C5a regulators in inflammatory disease. Expert Opin Investig Drugs 2005; 14:807-821.
21. Morley B, Walport M. The complement facts book. London: Academic Press; 2000.
22. Whaley K. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes. J Exp Med 1980; 151:501-516.
23. Colten HR, Ooi YM, Edelson PJ. Synthesis and secretion of complement proteins by macrophages. AnnN Y Acad Sci 1979; 332:482-490.
24. Schwaeble W, Schafer MK, Petry F, Fink T, Knebel D, Weihe E, Loos M. Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis. J Immunol 1995; 155:4971-4978.
25. Li K, Fazekasova H, Wang N, Sagoo P, Peng Q, Khamri W, et al. Expression of complement components, receptors and regulators by human dendritic cells. Mol Immunol 2011; 48:1121-1127.
26. Loos M, Storz R, Muller W, Lemmel EM. Immunofluorescence studies on the subcomponents of the first component of complement (C1): detection of C1q and C1 s in different cells of biopsy material and on human as well as on guinea pig peritoneal macrophages. Immunobiology 1981; 158:213-224.
27. Bensa JC, Reboul A, Colomb MG. Biosynthesis in vitro of complement subcomponents C1q, C1 s and C1 inhibitor by resting and stimulated human monocytes. Biochem J 1983; 216:385-392.
28. Castellano G, Trouw LA, Fiore N, Daha MR, Schena FP, van Kooten C. Infiltrating dendritic cells contribute to local synthesis of C1q in murine and human lupus nephritis. Mol Immunol 2010; 47:2129-2137. Project