Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis

Blood

Volumn 119, Issue 14, 2012, Pages 3315-3320

  Pean, Polidy ^a   Nerrienet, Eric ^a   Madec, Yoann ^b   Borand, Laurence ^a   Laureillard, Didier ^c,d   Fernandez, Marcelo ^c,e   Marcy, Olivier ^c   Sarin, Chan ^c,f   Phon, Kerya ^a   Taylor, Sylvia ^b   Pancino, Gianfranco ^b   Barré Sinoussi, Françoise ^b   Scott Algara, Daniel ^b  

^a INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^b INSTITUT PASTEUR   (France)

^c Cambodian Health Committee   (Cambodia)

^d Agence Nationale de Recherche Sur le Sida   (Viet Nam)

^e HARVARD MEDICAL SCHOOL   (United States)

^f Hopital Calmette   (Cambodia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CAMBODIA; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRANULATION; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MALE; NATURAL KILLER CELL; PREDICTOR VARIABLE; PRIORITY JOURNAL; TUBERCULOSIS; VIRUS LOAD;

EID: 84859592888     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-377523     Document Type: Article

References (32)

1. WHO global tuberculosis control report 2010. Summary. Cent Eur J Public Health. 2010;18(4):237.
2. Blanc FX, Sok T, Laureillard D, et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N Engl J Med. 2011;365(16):1471-1481.
3. Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M. Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(4):251-261.
4. Veenstra H, Baumann R, Carroll NM, et al. Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders. Clin Exp Immunol. 2006;145(2):252-260. (Pubitemid 44060115)
5. Scott-Algara D, Paul P. NK cells and HIV infection: lessons from other viruses. Curr Mol Med. 2002;2(8):757-768. (Pubitemid 35385974)
6. Stewart CA, Vivier E, Colonna M. Strategies of natural killer cell recognition and signaling. Curr Top Microbiol Immunol. 2006;298:1-21.
7. Fauci AS, Mavilio D, Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat Rev Immunol. 2005;5(11):835-843. (Pubitemid 41581665)
8. Mavilio D, Benjamin J, Daucher M, et al. Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci U S A. 2003;100(25):15011- 15016. (Pubitemid 37518008)
9. Carrington M, Martin MP, van Bergen J. KIR-HLA intercourse in HIV disease. Trends Microbiol. 2008;16(12):620-627.
10. Martin MP, Gao X, Lee JH, et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet. 2002;31(4):429-434. (Pubitemid 35154456)
11. Ravet S, Scott-Algara D, Bonnet E, et al. Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals. Blood. 2007;109(10):4296-4305. (Pubitemid 46743396)
12. Scott-Algara D, Arnold V, Didier C, et al. The CD85j+ NK cell subset potently controls HIV-1 replication in autologous dendritic cells. PLoS One. 2008;3(4):e1975.
13. Vankayalapati R, Barnes PF. Innate and adaptive immune responses to human Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2009;89(suppl 1):S77-S80.
14. Vankayalapati R, Wizel B, Weis SE, et al. The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium. J Immunol. 2002;168(7):3451-3457. (Pubitemid 34250410)
15. Garg A, Barnes PF, Porgador A, et al. Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor. J Immunol. 2006;177(9):6192-6198. (Pubitemid 44628837)
16. Vankayalapati R, Klucar P, Wizel B, et al. NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen. J Immunol. 2004;172(1):130-137. (Pubitemid 38020464)
17. Roy S, Barnes PF, Garg A, Wu S, Cosman D, Vankayalapati R. NK cells lyse T regulatory cells that expand in response to an intracellular pathogen. J Immunol. 2008;180(3):1729-1736.
18. Conradie F, Foulkes AS, Ive P, et al. Natural killer cell activation distinguishes M. tuberculosis-mediated Immune reconstitution syndrome (IRIS) from chronic HIV and HIV-MTB co-infection. J Acquir Immune Defic Syndr. 2011;58(3):309-318.
19. Blanc F, Sok T, Laureillard D, et al. Significant enhancement in survival with early (2 weeks) vs. late (8 weeks) initiation of highly active antiretroviral treatment (HAART) in severely immunosuppressed HIV-infected adults with newly diagnosed tuberculosis. Presented at 18th International AIDS Conference, July 23, 2010. Vienna, Austria.
20. Mavilio D, Lombardo G, Benjamin J, et al. Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. Proc Natl Acad Sci U S A. 2005;102(8):2886- 2891. (Pubitemid 40299886)
21. Strowig T, Brilot F, Munz C. Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol. 2008;180(12):7785-7791.
22. Antonelli LR, Mahnke Y, Hodge JN, et al. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood. 2010;116(19):3818-3827.
23. Bourgarit A, Carcelain G, Samri A, et al. Tuberculosis-associated immune restoration syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells. J Immunol. 2009;183(6):3915- 3923.
24. Seddiki N, Sasson SC, Santner-Nanan B, et al. Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease. Eur J Immunol. 2009;39(2):391-403.
25. Zhou H, Chen L, You Y, Zou L, Zou P. Foxp3-transduced polyclonal regulatory T cells suppress NK cell functions in a TGF-beta dependent manner. Autoimmunity. 2010;43(4):299-307.
26. Conradie F, Foulkes A, Yin X, et al. NK cell activation distinguishes M. tuberculosis-mediated IRIS from chronic HIV and HIV/MTB coinfection. J Acquir Immune Defic Syndr. 2011;58(3):309-318.
27. Oliver BG, Elliott JH, Price P, et al. Mediators of innate and adaptive immune responses differentially affect immune restoration disease associated with Mycobacterium tuberculosis in HIV patients beginning antiretroviral therapy. J Infect Dis. 2010;202(11):1728-1737.
28. Elliott JH, Vohith K, Saramony S, et al. Immunopathogenesis and diagnosis of tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome during early antiretroviral therapy. J Infect Dis. 2009;200(11):1736- 1745.
29. Zenhaeusern G, Gasser O, Honger G, Durovic B, Stern M, Hess C. Regulatory allospecific NK cell function is differentially associated with HLA C allotypes. Am J Transplant. 2009;9(11):2624-2630.
30. Zocchi MR, Contini P, Alfano M, Poggi A. Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit Tat-induced TGF-beta production by NK cells and TGF-beta-mediated NK cell apoptosis. J Immunol. 2005;174(10):6054-6061. (Pubitemid 40663793)
31. Deniz G, Erten G, Kucuksezer UC, et al. Regulatory NK cells suppress antigen-specific T cell responses. J Immunol. 2008;180(2):850-857.
32. Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limon P. The polarization of immune cells in the tumour environment by TGFbeta. Nat Rev Immunol. 2010;10(8):554-567.