A microfluidic system to study the cytotoxic effect of drugs: The combined effect of celecoxib and 5-fluorouracil on normal and cancer cells

Microchimica Acta

Volumn 180, Issue 9-10, 2013, Pages 895-901

  Jastrzebska, Elzbieta ^a   Flis, Sylwia ^b   Rakowska, Aleksandra ^a   Chudy, Michal ^a   Jastrzebski, Zenon ^b   Dybko, Artur ^a   Brzozka, Zbigniew ^a  

^a WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b NATIONAL MEDICINES INSTITUTE   (Poland)

Author keywords

5 fluorouracil; Celecoxib; Chemotherapy resistance; Lab on a chip; Microfluidic gradient system; Multidrug tests

Indexed keywords

EID: 84879874461     PISSN: 00263672     EISSN: 14365073     Source Type: Journal    
DOI: 10.1007/s00604-013-1009-4     Document Type: Article

References (30)

1. Danesi DT (2010) The association of chemotherapy and radiotherapy: biological rationale. Curr Drug The 5: 152.
2. Gadgeel SM, Ramalingam SS, Kalemkerian GP (2012) Treatment of lung cancer. Radiol Clin N Am 5: 961.
3. Ullah MF (2008) Cancer Multidrug Resistance (MDR): a major impediment to effective chemotherapy. Asian Pac J Cancer Prev 9: 1.
4. Irie T, Tsujii M, Tsuji S, Yoshio T, Ishii S, Shinzaki S, Egawa S, Kakiuchi Y, Nishida T, Yasumaru M, Iijima H, Murata H, Takehara T, Kawano S, Hayashi N (2007) Synergic antitumor effects of celecoxib with 5-fluorouracil depend on INF-y. Int J Cancer 4: 878.
5. Wilgus TA, Breza TS, Tober KL, Oberyszyn TM (2004) Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. J Investig Dermatol 122: 1488.
6. Wu MH, Huang SB, Lee GB (2010) Microfluidic cell culture systems for drug research. Lab Chip 10: 939.
7. Yeo LY, Chang HC, Chan PP, Friend JR (2011) Microfluidic devices for bioapplications. Small 7: 12.
8. Noort D, Ong SM, Zhang C, Arooz T, Yu H (2009) Stem cells in microfluidics. Biotechnol Prog 25: 52.
9. Gupta K, Kim DH, Ellison D, Smith C, Kundu A, Suh KY, Tuan J, Levchenko A (2010) Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip 10: 2019.
10. Beebe DJ, Mensing GA, Walker GM (2002) Physics and applications of microfluidics in biology. Annu Rev Biomed Eng 4: 261.
11. Neužil P, Giselbrecht S, Länge K, Huang TJ, Manz A (2012) Revisiting lab-on-a-chip technology for drug discovery. Nat Rev Drug Discov 11: 620.
12. Hung PJ, Lee PJ, Sabounchi P, Aghdam N, Lin R, Lee LP (2005) A novel high aspect ratio microfluidic design to provide a stable and uniform microenvironment for cell growth in a high throughput mammalian cell culture array. Lab Chip 5: 44.
13. Kim DH, Wong PK, Park J, Levchenko A, Sun Y (2009) Microengineered platforms for cell mechanobiolog. Annu Rev Biomed Eng 11: 203.
14. Dertinger KW, Chiu DT, Jeon NL, Whitesides GM (2001) Generation of gradients having complex shapes using microfluidic networks. Anal Chem 73: 1240.
15. Chung BG, Lin F, Jeon NL (2006) A microfluidic multi-injector for gradient generation. Lab Chip 6: 764.
16. Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MC (2006) Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip 6: 191.
17. Fung WT, Beyzavi A, Abgrall P, Nguyen NT, Li HY (2009) Microfluidic platform for controlling the differentiation of embryoid bodies. Lab Chip 9: 2591.
18. Piraino F, Camci-Unal G, Hancock MJ, Rasponi M, Khademhosseini A (2012) Multi-gradient hydrogels produced layer by layer with capillary flow and crosslinking in open microchannels. Lab Chip 12: 659.
19. Gomez-Sjoberg R, Leyrat AA, Pirone DM, Chen CS, Quake SR (2007) Versatile, fully automated, microfluidic cell culture system. Anal Chem 79: 8557.
20. Prokop A, Prokop Z, Schaffer D, Kozlov E, Wikswo J, Cliffel D, Baudenbacher F (2004) NanoLiterBioReactor: monitoring of long-term mammalian cell physiology at nanofabricated scale. Biomed Microdevices 6: 325.
21. Jeon N, Baskaran H, Dertinger SK (2002) Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nat Biotechnol 20: 826.
22. Wang SJ, Saadi W, Lin F, Nguyen CMC, Jeon NL (2004) Differential effects of EGF gradient profiles on MDA-MB-231 breast cancer cell chemotaxis. Exp Cell Res 300: 180.
23. Chung BG, Flangan LA, Rhee SW, Schwartz PH, Lee AP, Monuki ES, Jeon NL (2005) Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 5: 401.
24. Siyan W, Feng Y, Lichuan Z, Jiarui W, Yingyan W, Li J, Bingcheng L, Qi W (2009) Application of microfluidic gradient chip in the analysis of lung cancer chemotherapy resistance. J Pharm Biomed Anal 49: 806.
25. Dertinger S, Jiang X, Li Z, Murthy V, Whitesides GM (2002) Gradients of substrate-bound laminin orient axonal specification of neurons. PNAS 99: 12542.
26. Ma B, Zhang GH, Qin JH, Lin BC (2009) Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device. Lab Chip 9: 232.
27. Hosokawa M, Hayashi T, Mori T, Yoshino T, Nakasono S, Matsunaga T (2011) Microfluidic device with chemical gradient for single-cell cytotoxicity assays. Anal Chem 83: 3648.
28. Jedrych E, Flis S, Sofinska K, Jastrzebski Z, Chudy M, Brzozka Z (2011) Evaluation of cytotoxic effects of 5-fluorourcil on human carcinoma cells in microfluidic system. Sensors Actuators B Chem 160: 1544.
29. Corvi R, Aardema MJ, Gribaldo L, Hayashi M, Hoffmann S, Schechtman L, Vanparys P (2012) ECVAM prevalidation study on in vitro cell transformation assays: general outline and conclusions of the study. Mutat Res 11: 12.
30. Ziolkowska K, Jedrych E, Kwapiszewski R, Lopacinska J, Skolimowski M, Chudy M (2010) PDMS/glass Microfluidic cell culture system for cytotoxicity tests and cells passage. Sensors Actuators B Chem 145: 533.