Organization and function of transmitter release sites at the neuromuscular junction

Journal of Physiology

Volumn 591, Issue 13, 2013, Pages 3159-3165

  Meriney, Stephen D ^a   Dittrich, Markus ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PITTSBURGH SUPERCOMPUTING CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; NEUROTRANSMITTER; VOLTAGE GATED CALCIUM CHANNEL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

ANURA; ARTICLE; CALCIUM BINDING; CALCIUM TRANSPORT; CELL FUNCTION; CELLULAR DISTRIBUTION; COMPUTER MODEL; MATHEMATICAL COMPUTING; NERVE POTENTIAL; NERVE STIMULATION; NEUROMUSCULAR SYNAPSE; NEUROMUSCULAR TRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN FUNCTION; RELIABILITY; SIGNAL TRANSDUCTION; ANIMAL; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

ANIMALS; NEUROMUSCULAR JUNCTION; NEUROTRANSMITTER AGENTS; SYNAPTIC TRANSMISSION;

EID: 84879844170     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.248625     Document Type: Article

References (36)

1. Bekkers JM (1994). Quantal analysis of synaptic transmission in the central nervous system. Curr Opin Neurobiol 4, 360-365.
2. Bennett MR (1996). Neuromuscular transmission at an active zone: the secretosome hypothesis. J Neurocytol 25, 869-891.
3. 2+ sensor that triggers exocytosis Nat Rev Mol Cell Biol 3, 498-508.
4. Chen J, Mizushige T & Nishimune H (2012). Active zone density is conserved during synaptic growth but impaired in aged mice. J Comp Neurol 520, 434-452.
5. Dittrich M, Pattillo JM, King JD, Cho S, Stiles JR & Meriney SD (2013). An excess calcium binding site model predicts neurotransmitter release at the NMJ Biophysical J. (in press).
6. Feng TP (1941). Studies on the neuromuscular junction XXVI. The changes of the end-plate potential during and after prolonged stimulation. Chin J Physiol 16, 341-372.
7. Grinnell AD (1995). Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions. Physiol Rev 75, 789-834.
8. Harlow ML, Ress D, Stoschek A, Marshall RM & McMahan UJ (2001). The architecture of active zone material at the frog's neuromuscular junction. Nature 409, 479-484.
9. Heuser JE, Reese TS & Landis DM (1974). Functional changes in frog neuromuscular junctions studied with freeze-fracture. J Neurocytol 3, 109-131.
10. Heuser JE, Reese TS, Dennis MJ, Jan Y, Jan L & Evans L (1979). Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release. J Cell Biol 81, 275-300.
11. Katz B (1969). The Release of Neural Transmitter Substances Liverpool University Press, Liverpool
12. Katz B & Miledi R (1979). Estimates of quantal content during 'chemical potentiation' of transmitter release. Proc R Soc Lond B Biol Sci 205, 369-378.
13. Kerr RA, Bartol TM, Kaminsky B, Dittrich M, Chang JC, Baden SB, Sejnowski TJ & Stiles JR (2008). Fast Monte Carlo simulation methods for biological reaction-diffusion systems in solution and on surfaces. SIAM J Sci Comput 30, 3126.
14. Ko CP (1987). A lectin, peanut agglutinin, as a probe for the extracellular matrix in living neuromuscular junctions. J Neurocytol 16, 567-576.
15. Luo F, Dittrich M, Stiles JR & Meriney SD (2011). Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals. J Neurosci 31, 11268-11281.
16. Ma J, Dittrich M, Tarr T, Meriney SD & Stiles JR (2010). Computational Study of Active Zone Structure and Function at the Mammalian Neuromuscular Junction Program No. 448.11. 2010 Neuroscience Meeting Planner. Society for Neuroscience, Washington, DC Online. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=5918d739-ab0c-46f4-87ee-39b34e89f097&cKey=5a6369e6-7b2f-42d7-b06d-6a74332b2ab2&mKey=%7bE5D5C83F-CE2D-4D71-9DD6-FC7231E090FB%7d.
17. Ma J, Kelly L, Price T, Ingram J, Meriney SD, Dittrich M & Stiles J (2011). Computational Study of Persistent Calcium Binding Provides Insight into Short-Term Synaptic Facilitation Program No. 448.02. 2011 Neuroscience Meeting Planner. Society for Neuroscience, Washington, DC Online. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=bace4c2a-3ebd-4b6c-b9f2-b94276ea96f8&cKey=2793328a-81cd-4500-bdfc-36130fbbdb4a&mKey=%7b8334BE29-8911-4991-8C31-32B32DD5E6C8%7d.
18. Nagwaney S, Harlow ML, Jung JH, Szule JA, Ress D, Xu J, Marshall RM & McMahan UJ (2009). Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse. J Comp Neurol 513, 457-468.
19. Nishimune H, Sanes JR & Carlson SS (2004). A synaptic laminin-calcium channel interaction organizes active zones in motor nerve terminals. Nature 432, 580-587.
20. 2+ channel complex. FEBS Lett 326, 255-260.
21. Pawson PA, Grinnell AD & Wolowske B (1998). Quantitative freeze-fracture analysis of the frog neuromuscular junction synapse-I. Naturally occurring variability in active zone structure. J Neurocytol 27, 361-377.
22. Pumplin DW, Reese TS & Llinás R (1981). Are the presynaptic membrane particles the calcium channels Proc Natl Acad Sci U S A 78, 7210-7213.
23. Reddy LV, Koirala S, Sugiura Y, Herrera AA & Ko CP (2003). Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo. Neuron 40, 563-580.
24. Rogozhin AA, Pang KK, Bukharaeva E, Young C & Slater CR (2008). Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A. J Physiol 586, 3163-3182.
25. Ruiz R, Cano R, Casañas JJ, Gaffield MA, Betz WJ & Tabares L (2011). Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse. J Neurosci 31, 2000-2008.
26. 2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction. J Neurosci 26, 13240-13249.
27. Shon KJ, Olivera BM, Watkins M, Jacobsen RB, Gray WR, Floresca CZ, Cruz LJ, Hillyard DR, Brink A, Terlau H & Yoshikami D (1998). μ-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes. J Neurosci 18, 4473-4481.
28. Tabares L, Ruiz R, Linares-Clemente P, Gaffield MA, Alvarez de Toledo G, Fernandez-Chacón R & Betz WJ (2007). Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin. J Neurosci 27, 5422-5430.
29. Tarr TB, Dittrich M & Meriney SD (2013). Are unreliable release mechanisms conserved from NMJ to CNS Trends Neurosci 36, 14-22.
30. 2+ channels. Proc Natl Acad Sci U S A 100, 3491-3496.
31. Wachman ES, Poage RE, Stiles JR, Farkas DL & Meriney SD (2004). Spatial distribution of calcium entry evoked by single action potentials within the presynaptic active zone. J Neurosci 24, 2877-2885.
32. Wang X, Engisch KL, Li Y, Pinter MJ, Cope TC & Rich MM (2004). Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo. J Neurosci 24, 10687-10692.
33. 2+ dependence of the binomial parameters p and n at the mouse neuromuscular junction. J Neurophysiol 103, 659-666.
34. Wood SJ & Slater CR (2001). Safety factor at the neuromuscular junction. Prog Neurobiol 64, 393-429.
35. Wyatt RM & Balice-Gordon RJ (2008). Heterogeneity in synaptic vesicle release at neuromuscular synapses of mice expressing synaptopHluorin. J Neurosci 28, 325-335.
36. Yoshikami D, Bagabaldo Z & Olivera BM (1989). The inhibitory effects of omega-conotoxins on Ca channels and synapses. Ann N Y Acad Sci 560, 230-248.