The fatigue-motor performance paradox in multiple sclerosis

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Pardini, Matteo ^a   Bonzano, Laura ^a   Roccatagliata, Luca ^a   Mancardi, Giovanni L ^a   Bove, Marco ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; FATIGUE; HUMAN; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PSYCHOMOTOR PERFORMANCE;

FATIGUE; HUMANS; MAGNETIC RESONANCE IMAGING; MULTIPLE SCLEROSIS; PSYCHOMOTOR PERFORMANCE;

EID: 84879836259     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02001     Document Type: Article

References (28)

1. Chaudhuri, A. & Behan, P. O. Fatigue in neurological disorders. Lancet 363, 978-988 (2004). (Pubitemid 38388334)
2. Krupp, L. B., Alvarez, L. A., LaRocca, N. G. & Scheinberg, L. C. Fatigue in multiple sclerosis. Arch Neurol 45, 435-437 (1988). (Pubitemid 18098285)
3. Cook, D. B., O'Connor, P. J., Lange, G. & Steffener, J. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage 36, 108-122 (2007). (Pubitemid 46617953)
4. DeLuca, J., Genova, H. M.,Hillary, F. G.& Wylie, G. Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI. J Neurol Sci 270, 28-39 (2008).
5. Inglese, M. et al. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch Neurol 64, 196-202 (2007).
6. Pardini, M., Bonzano, L., Mancardi, G. L. & Roccatagliata, L. Frontal networks play a role in fatigue perception in multiple sclerosis. Behav Neurosci 124, 329-336 (2010).
7. Roelcke, U. et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology 48, 1566-1571 (1997).
8. Bove, M. et al. The effects of rate and sequence complexity on repetitive finger movements. Brain Res 1153, 84-91 (2007). (Pubitemid 46813136)
9. Stoodley, C. J. & Schmahmann, J. D. Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies. Neuroimage 44, 489-501 (2009).
10. Rao, S. M. et al. Distributed neural systems underlying the timing of movements. J Neurosci 17, 5528-5535 (1997). (Pubitemid 27300317)
11. Ivry, R. B. & Spencer, R. M. The neural representation of time. Curr Opin Neurobiol 14, 225-232 (2004). (Pubitemid 38479941)
12. Bonzano, L. et al. Basal ganglia are active duringmotor performance recovery after a demanding motor task. Neuroimage 65, 257-266 (2013).
13. Tajima, S. et al. Medial orbitofrontal cortex is associated with fatigue sensation. Neurol Res Int 2010, 671421 (2010).
14. Boksem, M. A. & Tops, M. Mental fatigue: costs and benefits. Brain Res Rev 59, 125-139 (2008).
15. Cavada, C., Company, T., Tejedor, J., Cruz-Rizzolo, R. J. & Reinoso-Suarez, F. The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex 10, 220-242 (2000). (Pubitemid 30159290)
16. Krienen, F. M. & Buckner, R. L. Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity. Cereb Cortex 19, 2485-2497 (2009).
17. Wallis, J. D. Neuronal mechanisms in prefrontal cortex underlying adaptive choice behavior. Ann N Y Acad Sci 1121, 447-460 (2007).
18. Kurtzke, J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33, 1444-1452 (1983). (Pubitemid 14237132)
19. Smith, A. Symbol Digit Modalities Test (SDMT): Manual (Western Psychological Services, Los Angeles, CA, 1982).
20. Deloire, M. S. et al. How to detect cognitive dysfunction at early stages of multiple sclerosis? Mult Scler 12, 445-452 (2006). (Pubitemid 44132585)
21. Amato, M. P. et al. The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian population. Mult Scler 12, 787-793 (2006). (Pubitemid 46111772)
22. First, M. B., Spitzer, R. L., Gibbon, M. & Williams, J. Research Version, Patient Edition. (SCID-I/P) (New York State Psychiatric Institute, New York, 2002).
23. Zigmond, A. S. & Snaith, R. P. The hospital anxiety and depression scale. Acta Psychiatr Scand 67, 361-370 (1983). (Pubitemid 13098606)
24. Bagby, R. M., Parker, J. D. & Taylor, G. J. The twenty-item Toronto Alexithymia Scale-I. Item selection and cross-validation of the factor structure. J Psychosom Res 38, 23-32 (1994).
25. Fisk, J. D. et al.Measuring the functional impact of fatigue: initial validation of the fatigue impact scale. Clin Infect Dis 18 Suppl 1, S79-83 (1994). (Pubitemid 24023890)
26. Oldfield, R. C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97-113 (1971).
27. Aschersleben, G. Temporal control of movements in sensorimotor synchronization. Brain Cogn 48, 66-79 (2002). (Pubitemid 34095193)
28. Friston, K. J. et al. Analysis of fMRI time-series revisited. Neuroimage 2, 45-53 (1995).