Knockdown of long non-coding RNA HOTAIR suppresses tumor invasion and reverses epithelial mesenchymal transition in gastric cancer

International Journal of Biological Sciences

Volumn 9, Issue 6, 2013, Pages 587-597

  Xu, Zhi Yuan ^a   Yu, Qi Ming ^a   Du, Yi An ^a   Yang, Li Tao ^a   Dong, Rui Zeng ^a   Huang, Ling ^a   Yu, Peng Fei ^a   Cheng, Xiang Dong ^a  

^a ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

Epithelial mesenchymal transition; Gastric cancer; HOTAIR; Long non coding RNA; Lymphatic node metastasis

Indexed keywords

HOTAIR; SMALL INTERFERING RNA; UNTRANSLATED RNA;

ADULT; AGED; ARTICLE; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; GENETICS; HUMAN; LONG NON-CODING RNA; LYMPHATIC NODE METASTASIS.; MALE; METASTASIS; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; STOMACH CANCER; STOMACH TUMOR; TUMOR INVASION; VERY ELDERLY;

EPITHELIAL-MESENCHYMAL TRANSITION; GASTRIC CANCER; HOTAIR; LONG NON-CODING RNA; LYMPHATIC NODE METASTASIS.;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; STOMACH NEOPLASMS;

EID: 84879833696     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.6339     Document Type: Article

References (23)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008; 58: 71-96.
2. Villanueva MT. Combination therapy: update on gastric cancer in East Asia. Nat Rev Clin Oncol. 2011; 8: 690.
3. Lin Y, Ueda J, Kikuchi S, et al. Comparative epidemiology of gastric cancer between Japan and China. World J Gastroenterol. 2011; 17: 4421-4428.
4. Stein LD. Human genome: end of the beginning. Nature. 2004; 431: 915-916.
5. Brosnan CA, Voinnet O. The long and the short of noncoding RNAs. Curr Opin Cell Biol. 2009; 21: 416-425.
6. Costa FF. Non-coding RNAs: new players in eukaryotic biology. Gene. 2005; 357: 83-94.
7. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006; 6: 857-866.
8. Popov N, Gil J. Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. Epigenetics. 2010; 5: 685-690.
9. Calin GA, Liu CG, Ferracin M, et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007; 12: 215-229.
10. Gutschner T, Diederichs S. The Hallmarks of Cancer: A long non-coding RNA point of view. RNA Biol. 2012 Jun;9(6):703-19.
11. Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 2007; 129: 1311-1323.
12. Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010; 464: 1071-1076.
13. Yang Z, Zhou L, Wu LM, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011; 18: 1243-1250.
14. Kim K, Jutooru I, Chadalapaka G, et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2012.
15. Ray PS, Wang J, Qu Y, et al. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res. 2010; 70: 3870-3876.
16. Xu ZY, Ding SM, Zhou L, et al. FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition. Int J Biol Sci. 2012; 8: 1130-1141.
17. Cheng J, Xie HY, Xu X, et al. NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma. Cancer Lett. 2011; 310: 35-45.
18. Niinuma T, Suzuki H, Nojima M, et al. Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. Cancer Res. 2012; 72: 1126-1136.
19. Geng YJ, Xie SL, Li Q, et al. Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 2011; 39: 2119-2128.
20. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011; 147: 275-292.
21. Gibb EA, Brown CJ, Lam WL. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 2011; 10: 38.
22. Bonnomet A, Brysse A, Tachsidis A, et al. Epithelial-to-mesenchymal transitions and circulating tumor cells. J Mammary Gland Biol Neoplasia. 2010; 15: 261-273.
23. Wan Y, Chang HY. HOTAIR: Flight of noncoding RNAs in cancer metastasis. Cell Cycle. 2010; 9: 3391-3392.