Synthesis, in vitro antifungal activity and in silico study of 3-(1,2,4-triazol-1-yl)flavanones

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 480-488

  Emami, Saeed ^a   Shojapour, Shahaboddin ^a   Faramarzi, Mohammad Ali ^b   Samadi, Nasrin ^c   Irannejad, Hamid ^a  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,2,4 Triazole; Antifungal activity; Azole antifungals; Docking study; Drug likeness; Flavanones

Indexed keywords

2 (2 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE NITRATE; 2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; 2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2 (3 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; 2 (4 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (2 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE NITRATE; 2,3 DIHYDRO 2 (3 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (4 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (4 METHOXYPHENYL) 3 (1H 1,2,4-TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (4 METHYLPHENYL) 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 PHENYL 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2,3 DIHYDRO 2 PHENYL 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1BENZOPYRAN 4 ONE; ANTIFUNGAL AGENT; FLAVANONE DERIVATIVE; FLUCONAZOLE; UNCLASSIFIED DRUG; VORICONAZOLE; KETOCONAZOLE; STEROL 14ALPHA DEMETHYLASE; TRANS 2 (2 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE NITRATE; TRANS 2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; TRANS 2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2 (3 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2 (4 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H 1,2,4 TRIAZOL 1YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 (2 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE NITRATE; TRANS 2,3 DIHYDRO 2 (3 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 (3 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 (4 FLUOROPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 (4 METHOXYPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 (4 METHYLPHENYL) 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 PHENYL 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1BENZOPYRAN 4 ONE; TRANS 2,3 DIHYDRO 2 PHENYL 3 (1H 1,2,4 TRIAZOL 1 YL) 4H 1BENZOPYRAN 4 ONE OXIME; TRIAZOLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; CANDIDA ALBICANS; COMPUTER MODEL; CONCENTRATION RESPONSE; DEAMINATION; DRUG CONFORMATION; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; SACCHAROMYCES CEREVISIAE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DILUTION; ENANTIOMER; INFRARED SPECTROSCOPY; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

EID: 84879824001     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.008     Document Type: Article

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