Design of conformationally constrained azole antifungals: Efficient synthesis and antifungal activity of trans-3-imidazolylflavanones

Chemical Biology and Drug Design

Volumn 73, Issue 4, 2009, Pages 388-395

  Emami, Saeed ^a   Behdad, Mehran ^a   Foroumadi, Alireza ^b   Falahati, Mehraban ^c   Lotfali, Ensieh ^c   Sharifynia, Somaye ^c  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antifungal activity; Azole antifungals; Flavanone; Imidazole; Oxime

Indexed keywords

2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2 (2,4 DICHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 4H 1 BENZYPYRAN 4 ONE; 2 (3 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2 (3 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 4H BENZOPYRAN 4 ONE; 2 (4 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 4H 1 BENZYPYRAN 4 ONE; 2 (4 CHLOROPHENYL) 2,3 DIHYDRO 3 (1H IMIDAZOLE 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2,3 DIHYDRO 2 (3 FLUOROPHENYL) 3 (1H IMIDAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (4 FLUOROPHENYL) 3 (1H IMIDAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE; 2,3 DIHYDRO 2 (4 FLUOROPHENYL) 3 (1H IMIDAZOL 1 YL) 4H 1 BENZOPYRAN 4 ONE OXIME; 2,3 DIHYDRO 3 (1H IMIDAZOL 1 YL) 2 PHENYL 4H 1 BENZOPYRAN 4 ONE OXIME; 2,3 DIHYDRO 3 (1H IMIDAZOLE 1 YL) 2 PHENYL 4H 1 BENZOPYRAN 4 ONE; 3 IMIDAZOLYLFLAVANONE; 3 IMIDAZOLYLFLAVANONE OXIME; ANTIFUNGAL AGENT; BENZALDEHYDE DERIVATIVE; BENZOPYRAN DERIVATIVE; FLAVANONE DERIVATIVE; FLUCONAZOLE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; OXIME DERIVATIVE; PHENYL GROUP; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRROLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; CANDIDA ALBICANS; CHEMICAL MODIFICATION; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL STRAIN; MICROSPORUM GYPSEUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ASPERGILLUS NIGER; FLAVANONES; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSPORUM; OXIMES; STEREOISOMERISM; YEASTS;

FUNGI;

EID: 61849165732     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00797.x     Document Type: Article

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