Alcohol and antiretroviral therapy - A lethal cocktail

Journal of AIDS and Clinical Research

Volumn 3, Issue SPL ISS1A, 2012, Pages

  Schneider, Michelle ^a   Neuman, Manuela ^b,c   Chersich, Matthew ^d,e   Parry, Charles ^a,f  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b In Vitro Drug Safety and Biotechnology   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^e GHENT UNIVERSITY   (Belgium)

^f STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

AIDS ARV; Alcohol; HAART; HIV; Immunology; Pharmacology

Indexed keywords

EID: 84879812566     PISSN: None     EISSN: 21556113     Source Type: Journal    
DOI: 10.4172/2155-6113.S1-005     Document Type: Article

References (83)

1. Rehm J, Rehn N, Room R, Monteiro M, Gmel G, et al. (2003) The global distribution of average volume of alcohol consumption and patterns of drinking. Eur Addict Res 9: 147-156.
2. UNAIDS, AIDS epidemic update (2009) "UNAIDS/09.36E / JC1700E". UNAIDS. World Health Organization.
3. Motlanthe K (2011) ARVs open to all. The Times, Sapa 12 August, 2011.
4. Motsoaledi A (2011) 'How we're re-engineering the health system, Motsoaledi: Health Budget Vote Policy Speech presented at the National Assembly.
5. Oh J, Hegele RA (2007) HIV-associated dyslipidaemia: pathogenesis and treatment. Lancet Infect Dis 7: 787-796.
6. Gmel G, Shield KD, Rehm J (2011) Developing a method to derive alcohol-attributable fractions for HIV/AIDS mortality based on alcohol's impact on adherence to antiretroviral medication. Popul Health Metr 9: 5.
7. Neblett RC, Hutton HE, Lau B, McCaul ME, Moore RD, et al. (2011) Alcohol consumption among HIV-infected women: impact on time to antiretroviral therapy and survival. J Women's Health (Larchmt) 20: 279-286.
8. Hahn JA, Bwana MB, Javors MA, Martin JN, Emenyonu NI, et al. (2010) Biomarker Testing to Estimate Under-Reported Heavy Alcohol Consumption by Persons with HIV Initiating ART in Uganda. AIDS Behav 14: 1265-1268.
9. World Health Organization (2011) Global Status Report on Alcohol and Health. Geneva.
10. Míguez-Burbano MJ, Lewis JE, Fishman J, Asthana D, Malow RM (2009) The influence of different types of alcoholic beverages on disrupting highly active antiretroviral treatment (HAART) outcome. Alcohol and Alcoholism 44: 366-371.
11. Baliunas D, Rehm J, Irving H, Shuper P (2010) Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis. Alcohol consumption and risk of incident human immunodeficiency virus infection: a meta-analysis. Int J Public Health 55: 159-166.
12. Shuper PA, Neuman M, Kanteres F, Baliunas D, Joharchi N, et al. (2010) Causal considerations on alcohol and HIV/AIDS a systematic. Alcohol Alcohol 45: 159-166.
13. Braithwaite RS, Conigliaro J, Roberts MS, Shechter S, Schaefer A, et al. (2007) Estimating the impact of alcohol consumption on survival for HIV-individuals. AIDS Care 19: 459-466.
14. Kalichman SC (1999) Psychological and social correlates of high-risk sexual behaviour among men and women living with HIV/AIDS. AIDS Care 11: 415-427.
15. Kalichman SC, Rompa D, Cage M (2000) Sexually transmitted infections among HIV seropositive men and women. Sex Transm Infect 76: 350-354.
16. Kalichman SC, Simbayi LC, Kaufman M, Cain D, Jooste S (2007) Alcohol use and sexual risks for HIV/AIDS in sub-Saharan Africa: systematic review of empirical findings. Prev Sci 8: 141-151.
17. Brennan DJ, Welles SL, Miner MH, Ross MW, Rosser BR, et al. (2010) HIV treatment optimism and unsafe anal intercourse among HIV-positive men who have sex with men: findings from the positive connections study. AIDS Educ Prev 22: 126-137.
18. Do NT, Phiri K, Bussmann H, Gaolathe T, Marlink RG, et al. (2010) Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. AIDS Res Hum Retroviruses 26: 685-691.
19. Andreani G, Espada C, Ceballos A, Ambrosioni J, Petroni A, et al. (2011) Detection of HIV-1 dual infections in highly exposed treated patients. Virol J 8: 392.
20. Wasserheit JN (1992) Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis 19: 61-77.
21. Theall KP, Amedee A, Clark RA Dumestre J, Kissinger P (2008) Alcohol consumption and HIV-1 vaginal RNA shedding among women. J Stud Alcohol Drugs 69: 454-458.
22. Lima V, Harrigan R, Murray M, Moore D, Wood E, et al. (2008) Differential impact of adherence on long-term treatment response among naive HIV-infected individuals. AIDS 22: 2371-2380.
23. Gardner EM, Burma WJ, Steiner JF, Anderson PL, Bangsberg DR (2009) Antiretroviral medication adherence and the development of class-specific antiretroviral resistance. AIDS 23: 1035-1046.
24. Jaspan HB, Mueller AD, Myer L, Bekker LG, Orrell C (2011) Effect of Caregivers' Depression and Alcohol Use on Child Antiretroviral Adherence in South Africa. AIDS Patient Care STDS 25: 595-600.
25. Hendershot C, Stoner S, Pantalone, Simoni J (2009) Alcohol Use and Antiretroviral Adherence: Review and Meta-Analysis. J Acquir Immune Defic Syndr 52: 180-202.
26. Dahab M, Charalambous S, Hamilton R, Fielding K, Kielmann K, et al. (2008) "That is why I stopped the ART": Patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health 8: 63.
27. Venkatesh KK, Srikrishnan AK, Mayer KH, Kumarasamy N, Raminani S, et al. (2010) Predictors of nonadherence to highly active antiretroviral therapy among HIV-infected South Indians in clinical care: implications for developing adherence interventions in resource-limited settings. AIDS Patient Care STDS 24: 795-803.
28. Jaquet A, Ekouevi DK, Bashi J, Aboubakrine M, Messou E, et al. (2010) Alcohol use and non-adherence to antiretroviral therapy in HIV-infected patients in West Africa. Addiction 105: 1416-1421.
29. Van Geertruyden JP, Woelk G, Mukumbi H, Ryder H, Colebunders R (2010) Alcohol and Antiretroviral Adherence? What About Africa? Letters to the Editor J Acquir Immune Defic Syndr 54: e10.
30. Díaz LE, Montero A, González-Gross M, Vallejo AI, Romeo J, et al. (2002) Influence of alcohol consumption on immunological status: a review. Eur J Clin Nutr 56: S50-S53.
31. Watzl B, Watson RR (1992) Role of alcohol abuse in nutritional immunosuppression. J Nutr 122: 733-737.
32. Balagopal A, Philip FH, Astemborski J, Block TM, Mehta A, et al. (2008) Human Immunodeficiency Virus-Related Microbial Translocation and Progression of Hepatitis C. Gastroenterology135: 226-233.
33. Molina PE, McClain C, Valla D, Guidot D, Diehl AM, et al. (2002) Molecular pathology and clinical aspects of alcohol induced tissue injury. Alcohol Clin Exp Res 26: 120-128.
34. Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA (2003) Alcohol consumption and HIV disease progression: Are they related? Alcohol Clin Exp Res 27: 862-867.
35. Samet JH, Cheng DM, Libman H, Nunes DP, Alperen JK, et al. (2007) Alcohol consumption and HIV disease progression. J Acquir Immune Defic Syndr 46: 194-199.
36. Fabris P, Tositti G, Manfrin V, Giordani MT, Vaglia A, et al. (2000) Does alcohol intake affect highly active antiretroviral therapy (HAART) response in HIVpositive patients? J AIDS 25: 92-93.
37. Baum MK, Rafie C, Lai S, Sales S, Page JB, et al. (2010) Alcohol Use Accelerates HIV Disease Progression. AIDS Research and Human Retroviruses 26: 511-518.
38. Goral J, Karavitis J, Kovacs EJ (2008) Exposure-dependent effects of ethanol on the innate immune system. Alcohol 42: 237-247.
39. Meadows GG, Wallendal M, Kosugi A, Wunderlich J, Singer DS (1992) Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol Clin Exp Res 16: 474-479.
40. Szabo G (1999) Consequences of alcohol consumption on host defence. Alcohol 34: 830-841.
41. National Institute on Alcohol Abuse and Alcholism (2006) Niaaa Plan for Hiv-Related Biomedical Research: Strenthening Alcohol and HIV / AIDS Biomedical Research. Report to the Extramural Advisory Board October 4-5.
42. Neuman MG, Monteiro M, Rehm J (2006) Drug Interactions between Psychoactive Substances and Antiretroviral Therapy in Individuals Infected With Human Immunodeficiency and Hepatitis Viruses. Subst Use Misuse 41: 1395-1463.
43. Neuman MG, Brenner DA, Rehermann B, Taieb J, Chollet-Martin S (2001) Mechanisms of alcoholic liver disease. Alcohol Clin Exp Res 25: 251S-253S.
44. Lieber CS (1978) Pathogenesis and early diagnosis of alcoholic liver injury. N Engl J Med 298: 888-893.
45. Lieber CS (2000) Hepatic, metabolic, and nutritional disorders of alcoholism: from pathogenesis to therapy. Crit Rev Clin Lab Sci 37: 551-584.
46. Neuman MG, Shear NH, Cameron RG, Katz G, Tiribelli C (1999) Ethanol-Induced Apoptosis In Vitro. Clin Biochem 32: 547-555.
47. Parker WB, Cheng YC (1994) Mitochondrial toxicity of antiviral nucleoside analogs. J NIH RES 6: 57-61.
48. Lieber CS (2004) CYP2E1: from ASH to NASH. Hepatol Res 28: 1-11.
49. Miguez MJ, Shor-Posner G, Morales G, Rodriguez A, Burbano X (2003) HIV treatment in drug abusers: impact of alcohol use. Addict Biol 8: 33-37.
50. Zimmerman HJ (1999) Hepatotoxicity the adverse effects of drugs and other chemicals on the liver. (pp. 498-509) 2 ed. Philadelphia: Lippincott Williams and Wilkins.
51. Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S (2010) Alcohol's role in HIV transmission and disease progression. Alcohol Res Health 33: 203-218.
52. Jiménez-Nácher I, Alvarez E, Morello J, Rodriguez-Nóvoa S, de Andrés S, et al. (2011) Approaches for understanding and predicting drug interactions in human immunodeficiency virus-infected patients. Expert Opin Drug Metab Toxicol 7: 457-477.
53. DeLeve LD, Kaplowitz N (1991) Glutathione metabolism and its role in hepatotoxicity. Pharmac Ther 52: 287-305.
54. Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, et al. (1989) Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 2: 1294-1298.
55. Staal FJ, Ela SW, Roederer M, Anderson MT, Herzenberg LA (1992) Glutathione deficiency and human immunodeficiency virus infection. Lancet 339: 909-912.
56. Vogel M, Boesecke C, Wasmuth JC, Rockstroh JK (2010) HIV and hepatitis C co-infection. Dtsch Med Wochenschr 135: 1186-1191.
57. Romeo R, Rumi MG, Donato MF, Cargnel MA, Vigano P (2000) Hepatitis C is more severe in drug users with human immunodeficiency virus infection. J Viral Hepatitis 7: 297-301.
58. Prakash O, Mason A, Luftig RB, Bautista AP (2002) Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) infections in alcoholics. Front Biosci 1: e286-300.
59. Míguez-Burbano MJ, Lewis JE, Malow R (2009) "Alcohol and race/ethnicity elicit different changes in lipid profiles in HIV-infected individuals receiving highly active antiretroviral therapy". The J Assoc Nurses AIDS Care 20: 176-183.
60. Neuman MG, Malkiewicz IM, Phillips EJ, Rachlis A, Ong D, et al. (2002) Monitoring adverse drug reactions to sulphonamide antibiotics in human immunodeficiency virus infected individuals. Therapeutic Drug Monitoring 24: 728-736.
61. Fulco PP, Zingone MM, Higginson RT (2008) Possible Antiretroviral Therapy-Warfarin Drug Interaction. Pharmacotherapy 28: 945-949.
62. Rehm J, Samokhvalov AV, Neuman MG, Room R, Parry C, et al. (2009) The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review. BMC Public Health 9: 450.
63. Bruce RD, Altice FL, Gourevitch MN, Friedland GH (2006) Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practice. J Acquir Immune Defic Syndr 41: 563-572.
64. Cvetkovic RS, Goa KL (2003) Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 63:769-802.
65. McCance-Katz EF, Rainey PM, Friedland G, Kosten TR, Jatlow P (2001) Effect of opioid dependence pharmacotherapies on zidovudine disposition. Am J Addict 10: 296-307.
66. Barber TJ, Marett B, Waldron S, Portsmouth S, Mackie NE, et al. (2007) Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice? AIDS 21: 1823-1824.
67. Sullivan LE, Saitz R, Cheng DM, Libman H, Nunes D, et al. (2008) The impact of alcohol use on depressive symptoms in human immunodeficiency virusinfected patients. Addiction 103: 1461-1467.
68. Leserman J (2008) Role of depression, stress, and trauma in HIV diseaseprogression. Psychosom Med 70: 539-545.
69. Chopra M, Kendall C, Hill Z, Schaay N, Nkonki LL, et al. (2006) "Nothing new": responses to the introduction of antiretroviral drugs in South Africa. AIDS 20: 1975-1977.
70. Mogatle S, Skinner M, Mills E, Kanfer I (2008) Effect of African potato (Hypoxis hemerocallidea) on the pharmacokinetics of efavirenz. S Afr Med J 98: 945-949.
71. Morojele NK, Pithey AL, Kekwaletswe CT, Joubert-Wallis M, Pule MI, et al. (2010) South African health care providers recognition of the links between alcohol and HIV in their daily practice: a pilot study. African Journal of Drug and Alcohol Studies 9: 1-14.
72. Kalichman SC, Amaral CM, White D, Swetsze C, Howard P, et al. (2009) Prevalence and Clinical Implications of Interactive Toxicity Beliefs Regarding Mixing Alcohol and Antiretroviral Therapies among People Living with HIV/AIDS. AIDS Patient Care STDs 23: 449-454.
73. Fitzgerald M, Collumbien M, Hosegood V (2010) "No one can ask me 'Why do you take that stuff?'": men's experiences of antiretroviral treatment in South Africa. AIDS Care 22: 355-360.
74. Shacham E, Agbebi A, Stamm K, Overton ET (2011) Alcohol consumption is associated with poor health in HIV clinic patient population: a behavioral surveillance study. AIDS Behav 15: 209-213.
75. Sankar A, Wunderlich T, Neufeld S, Luborsky M, (2007) Sero-positive African Americans "Beliefs about Alcohol and Their Impact on Anti-retroviral Adherence. AIDS Behav 11: 195-203.
76. Hahn JA, Woolf-King SE, Muyindike W (2011) Adding Fuel to the Fire: Alcohol's Effect on the HIV Epidemic in Sub-Saharan Africa. Curr HIV/AIDS Rep 8: 172-180.
77. Bryant KJ (2006) Expanding Research on the Role of Alcohol Consumption and Related Risks in the Prevention and Treatment of HIV/AIDS. Substance Use & Misuse 41: 1465-1507.
78. Delva W, Pretorius C, Temmerman M (2009) Is scaling up enough to curb the HIV epidemic in southern Africa? SAMJ 99: 638-639.
79. Michel L, Carrieri MP, Fugon L, Roux P, Aubin HJ, et al. (2010) Harmful alcohol consumption and patterns of substance use in HIV-infected patients receiving antiretrovirals (ANRS-EN12-VESPA Study): relevance for clinical management and intervention. AIDS Care 22: 1136-1145.
80. Luchters S, Geibel S, Syengo M, Lango D, Kingola N, et al. (2011) Use of AUDIT, and measures of drinking frequency and patterns to detect associations between alcohol and sexual behaviour in male sex workers in Kenya. BMC Public Health 11: 384.
81. Kader R, Seedat S, Koch, JR, Parry CDH (in press) A preliminary investigation of the AUDIT and DUDIT in comparison to biomarkers for alcohol and drug use among HIV-infected clinic attendees in Cape Town, South Africa. African Journal of Psychiatry.
82. Parry CDH, Rehm J, Morojele NK (2010) Is There A Causal Relationship Between Alcohol and HIV? Implications for Policy Practice and Future Research. Journal of Drug and Alcohol Studies 9: 81-91.
83. Chersich MF, Rees HV, Scorgie F, Martin G (2009) Enhancing global control of alcohol to reduce unsafe sex and HIV in sub-Saharan Africa. Global Health 5: 16.