TGFβ1 alters androgenic metabolites and hydroxysteroid dehydrogenase enzyme expression in human prostate reactive stromal primary cells: Is steroid metabolism altered by prostate reactive stromal microenvironment?

Journal of Steroid Biochemistry and Molecular Biology

Volumn 138, Issue , 2013, Pages 206-213

  Piao, Yun Shang ^a   Wiesenfeld, Paddy ^b   Sprando, Robert ^b   Arnold, Julia T ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Androstenedione; DHEA; Reactive prostate stroma; Steroid metabolism; Testosterone; TGF 1

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 5; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANDROSTANOLONE; ANDROSTENEDIONE; HYDROXYSTEROID DEHYDROGENASE; MESSENGER RNA; PRASTERONE SULFATE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANDROGEN METABOLISM; ARTICLE; CANCER CELL; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PROSTATE CANCER; PROSTATE STROMAL CELL; STEROID METABOLISM; STROMA CELL; T LYMPHOCYTE; TUMOR CELL LINE; TUMOR MICROENVIRONMENT; UPREGULATION;

17Β-HYDROXYSTEROID DEHYDROGENASE TYPE 2 OR TYPE 5; 17HSD2 OR 17HSD5; 4-DIONE; 5Α-ANDROSTANEDIONE; 5-DIOL; 6S; A-DIONE; ANALYSIS OF VARIANCE; ANDROGEN RECEPTOR; ANDROSTENEDIOL; ANDROSTENEDIONE; ANOVA; AR; CANCER-DERIVED PRIMARY STROMAL CELLS; DEHYDROEPIANDROSTERONE; DHEA; DHEA SULFATE; DHEAS; DHT; DIHYDROTESTOSTERONE; DMEM; DULBECCO'S MODIFIED EAGLES MEDIA; E1; E2; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; ESTRONE; FBS; FETAL BOVINE SERUM; HSD; HYDROXYSTEROID DEHYDROGENASE; NORMAL PRIMARY PROSTATE STROMAL CELLS; PRSC; REACTIVE PROSTATE STROMA; S.E.M.; STANDARD ERROR OF THE MEAN; STEROID METABOLISM; T; TESTOSTERONE; TGFΒ1; TRANSFORMING GROWTH FACTORΒ-1;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ANDROSTENEDIONE; CELL LINE, TUMOR; DEHYDROEPIANDROSTERONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROXYSTEROID DEHYDROGENASES; MALE; PROSTATE; PROSTATIC NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; STROMAL CELLS; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84879805657     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.05.016     Document Type: Article

References (45)

1. D.A. Barron, and D.R. Rowley The reactive stroma microenvironment and prostate cancer progression Endocrine-related Cancer 19 2012 187 204
2. C. Alberti Prostate cancer progression and surrounding microenvironment The International Journal of Biological Markers 21 2006 88 95 (Pubitemid 44210037)
3. Y.N. Niu, and S.J. Xia Stroma-epithelium crosstalk in prostate cancer Asian Journal of Andrology 11 2009 28 35
4. J.A. Tuxhorn, G.E. Ayala, M.J. Smith, V.C. Smith, and T.D. Dang Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling Clinical Cancer Research 8 2002 2912 2923 (Pubitemid 35025739)
5. P. Soronen, M. Laiti, S. Torn, P. Harkonen, and L. Patrikainen Sex steroid hormone metabolism and prostate cancer The Journal of Steroid Biochemistry and Molecular Biology 92 2004 281 286 (Pubitemid 40128249)
6. F. Labrie Intracrinology Molecular and Cellular Endocrinology 78 1991 C113 C118
7. A. Belanger, B. Candas, A. Dupont, L. Cusan, and P. Diamond Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men The Journal of Clinical Endocrinology and Metabolism 79 1994 1086 1090 (Pubitemid 24342252)
8. J. Geller Rationale for blockade of adrenal as well as testicular androgens in the treatment of advanced prostate cancer Seminars in Oncology 12 1985 28 35 (Pubitemid 15149394)
9. E.E. Baulieu Dehydroepiandrosterone (DHEA): a fountain of youth? The Journal of Clinical Endocrinology and Metabolism 81 1996 3147 3151
10. N. Orentreich, J.L. Brind, J.H. Vogelman, R. Andres, and H. Baldwin Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men The Journal of Clinical Endocrinology and Metabolism 75 1992 1002 1004
11. S. Alesci, I. Manoli, and M.R. Blackman Dehydrodepiandrosterone (DHEA) P. Coates, Encyclopedia of Dietary Supplements 1st ed. 2005 Marcel Dekker, Inc. New York, NY 167 176
12. H. Klein, T. Molwitz, and W. Bartsch Steroid sulfate sulfatase in human benign prostatic hyperplasia: characterization and quantification of the enzyme in epithelium and stroma Journal of Steroid Biochemistry 33 1989 195 200 (Pubitemid 19218749)
13. K.H. Chang, R. Li, M. Papari-Zareei, L. Watumull, and Y.D. Zhao Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer Proceedings of the National Academy of Sciences of the United States of America 108 2011 13728 13733
14. J.P. Elo, L.A. Akinola, M. Poutanen, P. Vihko, and A.P. Kyllonen Characterization of 17beta-hydroxysteroid dehydrogenase isoenzyme expression in benign and malignant human prostate International Journal of Cancer 66 1996 37 41 (Pubitemid 26120897)
15. S.J. Ellem, and G.P. Risbridger Aromatase and prostate cancer Minerva Endocrinologica 31 2006 1 12
16. N. Cherradi, E.M. Chambaz, and G. Defaye Type beta 1 transforming growth factor is an inhibitor of 3 beta-hydroxysteroid dehydrogenase isomerase in mouse adrenal tumor cell line Y1 Endocrine Research 21 1995 61 66
17. D. Naville, W.E. Rainey, and J.I. Mason Corticotropin regulation of 3 beta-hydroxysteroid dehydrogenase/delta 5-4-isomerase in ovine adrenocortical cells: inhibition by transforming growth factor beta Molecular and Cellular Endocrinology 75 1991 257 263
18. A.K. Stankovic, L.D. Dion, and C.R. Parker Jr. Effects of transforming growth factor-beta on human fetal adrenal steroid production Molecular and Cellular Endocrinology 99 1994 145 151 (Pubitemid 24076960)
19. Y.S. Ee, L.C. Lai, K. Reimann, and P.K. Lim Effect of transforming growth factor-beta1 on oestrogen metabolism in MCF-7 and MDA-MB-231 breast cancer cell lines Oncology Reports 6 1999 843 846
20. S.F. Wong, K. Reimann, and L.C. Lai Effect of transforming growth factor-beta1, insulin-like growth factor-I and insulin-like growth factor-II on cell growth and oestrogen metabolism in human breast cancer cell lines Pathology 33 2001 454 459 (Pubitemid 34032950)
21. N.E. Gray, X. Liu, R. Choi, M.R. Blackman, and J.T. Arnold Endocrine immune-paracrine interactions in prostate cells as targeted by phytomedicines Cancer Prevention and Research 2 2009 134 142
22. A.T. Weeraratna, J.T. Arnold, D.J. George, A. DeMarzo, and J.T. Isaacs Rational basis for Trk inhibition therapy for prostate cancer Prostate 45 2000 140 148
23. H. Le, J.T. Arnold, K.K. McFann, and M.R. Blackman DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells American Journal of Physiology. Endocrinology and Metabolism 290 2006 E952 E960
24. K.A. Klein, R.E. Reiter, J. Redula, H. Moradi, and X.L. Zhu Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice Nature Medicine 3 1997 402 408 (Pubitemid 27145681)
25. A. Latil, I. Bieche, D. Vidaud, R. Lidereau, and P. Berthon Evaluation of androgen, estrogen (ER alpha and ER beta), and progesterone receptor expression in human prostate cancer by real-time quantitative reverse transcription- polymerase chain reaction assays Cancer Research 61 2001 1919 1926 (Pubitemid 32692008)
26. G. Vollmer, H. Michna, M.R. Schneider, and R. Knuppen Stromal expression of tenascin is inversely correlated to epithelial differentiation of hormone dependent tissues The Journal of Steroid Biochemistry and Molecular Biology 48 1994 487 494 (Pubitemid 24171875)
27. J.T. Arnold, N.E. Gray, K. Jacobowitz, L. Viswanathan, and P.W. Cheung Human prostate stromal cells stimulate increased PSA production in DHEA-treated prostate cancer epithelial cells The Journal of Steroid Biochemistry and Molecular Biology 111 2008 240 246
28. A.M. De Marzo, E.A. Platz, S. Sutcliffe, J. Xu, H. Gronberg, C.G. Drake, Y. Nakai, W.B. Isaacs, and W.G. Nelson Inflammation in prostate carcinogenesis Nature Reviews. Cancer 7 2007 256 269 (Pubitemid 46486616)
29. A.M. De Marzo, V.L. Marchi, J.I. Epstein, and W.G. Nelson Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis The American Journal of Pathology 155 1999 1985 1992
30. H. Pham, and V.A. Ziboh 5 alpha-reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids The Journal of Steroid Biochemistry and Molecular Biology 82 2002 393 400 (Pubitemid 36183192)
31. V. Luu-The, A. Belanger, and F. Labrie Androgen biosynthetic pathways in the human prostate Best Practice & Research. Clinical Endocrinology & Metabolism 22 2008 207 221 (Pubitemid 351611954)
32. M. El-Alfy, V. Luu-The, X.F. Huang, L. Berger, and F. Labrie Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry Endocrinology 140 1999 1481 1491 (Pubitemid 29104255)
33. K.M. Fung, E.N. Samara, C. Wong, A. Metwalli, and R. Krlin Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma Endocrine-related Cancer 13 2006 169 180
34. H.K. Lin, S. Steckelbroeck, K.M. Fung, A.N. Jones, and T.M. Penning Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate Steroids 69 2004 795 801 (Pubitemid 39593392)
35. G. Pelletier, V. Luu-The, B. Tetu, and F. Labrie Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues The Journal of Histochemistry and Cytochemistry 47 1999 731 738
36. R. Li, K. Evaul, K.K. Sharma, K.H. Chang, and J. Yoshimoto Abiraterone inhibits 3beta-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer Clinical Cancer Research 18 2012 3571 3579
37. J. Cheng, Y. Wu, J.L. Mohler, and C. Ip The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction Cancer Biology & Therapy 9 2010 1033 1042
38. T.M. Penning, and M.C. Byrns Steroid hormone transforming aldo-keto reductases and cancer Annals of the New York Academy of Sciences 1155 2009 33 42
39. H. Engelhardt, F.R. Tekpetey, R.E. Gore-Langton, and D.T. Armstrong Regulation of steroid production in cultured porcine thecal cells by transforming growth factor-beta Molecular and Cellular Endocrinology 85 1992 117 126
40. C. Sordoillet, M.A. Chauvin, J.C. Hendrick, P. Franchimont, and A.M. Morera Sites of interaction between epidermal growth factor and transforming growth factor-beta 1 in the control of steroidogenesis in cultured porcine Leydig cells Endocrinology 130 1992 1352 1358
41. Y. Li, V. Isomaa, A. Pulkka, R. Herva, and H. Peltoketo Expression of 3beta-hydroxysteroid dehydrogenase type 1, P450 aromatase, and 17beta-hydroxysteroid dehydrogenase types 1, 2, 5 and 7 mRNAs in human early and mid-gestation placentas Placenta 26 2005 387 392 (Pubitemid 40567916)
42. X.H. Li, Z. Xiu, and Piao YS Transforming growth factor-beta1 and epidermal growth factor decrease the expression of 17beta-hydroxysteroid dehydrogenase type 2 in endometrial carcinoma cells Chinese Science Bulletin 47 2002 43 46
43. J.T. Arnold DHEA metabolism in prostate: for better or worse? Molecular and Cellular Endocrinology 301 2009 83 88
44. G. Vollmer, J. Helle, H. Amri, X. Liu, and J.T. Arnold The EPI bioassay identifies natural compounds with estrogenic activity that are potent inhibitors of androgenic pathways in human prostate stromal and epithelial cells The Journal of Steroid Biochemistry and Molecular Biology 129 2012 153 162
45. T.S. Vasaitis, R.D. Bruno, and V.C. Njar CYP17 inhibitors for prostate cancer therapy The Journal of Steroid Biochemistry and Molecular Biology 125 1/2 2011 23 31