Evaluation and comparison of soluble transferrin receptor in thalassemia carriers and iron deficient patients

Hemoglobin

Volumn 37, Issue 4, 2013, Pages 387-395

  Khatami, Shohreh ^a   Dehnabeh, Soghra Rouhi ^a   Mostafavi, Ehsan ^a   Kamalzadeh, Neda ^b   Yaghmaei, Paricheher ^b   Saeedi, Parinaz ^a   Shariat, Farangis ^c   Bagheriyan, Hamideh ^d   Zeinali, Sirous ^a,d   Akbari, Mohammad Taghi ^e,f  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c Noor Pathobiology Lab   (Iran)

^d Medical Genetics Laboratory of Dr Zeinali   (Iran)

^e TARBIAT MODARES UNIVERSITY   (Iran)

^f Tehran Medical Genetics Laboratory   (Iran)

Author keywords

Anemia; Iron deficiency; Soluble transferrin receptor (sTfR); Soluble transferrin receptor log ferritin index (sTfR F index); Thalassemia; Transferrin receptor (TfR)

Indexed keywords

FERRITIN; HEMOGLOBIN; TRANSFERRIN RECEPTOR;

ALPHA THALASSEMIA; ARTICLE; BETA THALASSEMIA; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; ERYTHROCYTE; FEMALE; HEMATOCRIT; HUMAN; HUMAN TISSUE; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL;

ANEMIA, IRON-DEFICIENCY; CROSS-SECTIONAL STUDIES; ERYTHROCYTE INDICES; FEMALE; HEMOGLOBINS; HETEROZYGOTE; HUMANS; IRON; MALE; RECEPTORS, TRANSFERRIN; THALASSEMIA;

EID: 84879803751     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.3109/03630269.2013.780248     Document Type: Article

References (23)

1. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol. 1998;35(1):35-54.
2. Huebers HA, Csiba E, Huebers E, Finch CA. Competitive advantage of diferric transferrin in delivering iron to reticulocytes. Proc Natl Acad Sci USA. 1983;80(1):300-304.
3. Cazzola M, Pootrakul P, Bergamaschi G, Huebers HA, Eng M, Finch CA. Adequacy of iron supply for erythropoiesis: in vivo observations in humans. J Lab Clin Med. 1987;110(6):734-739.
4. Soluble Transferrin Receptor (sTfR) Minireviews, First printed in the R&D Systems' 1998 Catalog (http://www.rndsystems.com/mini-review-detail- objectname-MR98-sTfR.aspx).
5. Canonne-Hergaux F, Zhang A-S, Ponka P, Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;98(13): 3823-3830.
6. Katz JH. Iron and protein kinetics studied by means of doubly labeled human crystalline transferrin. J Clin Invest. 1961;40(12):2143-2152.
7. Li H, Ginzburg YZ. Crosstalk between iron metabolism and erythropoiesis. Adv Hematol. 2010; 2010:605435.
8. Ward JH, Kushner JP, Ray FA, Kaplan J. Transferrin receptor function in hereditary hemochromatosis. J Lab Clin Med. 1984;103(2):246-254.
9. Kohgo Y, Niitsu Y, Nishisato T. Externalization of transferrin receptor in established human cell lines. Cell Biol Int Rep. 1987;11(12):871-879.
10. R'zik S, Beguin Y. Serum soluble transferrin receptor concentration is an accurate estimate of the mass of tissue receptors. Exp Hematol. 2001;29(1):677-685.
11. Kohgo Y, Niitsu Y, Kondo H. Serum transferrin receptor as a new index of erythropoiesis. Blood. 1987;70(6):1955-1958.
12. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood. 1990;75(1):102-107.
13. Uaprasert N, Rojnuckarin P, Bhokaisawan N, et al. Elevated serum transferrin receptor levels in common types of thalassemia heterozygotes in Southeast Asia: a correlation with genotypes and red cell indices. Clin Chim Acta. 2009;403(1-2):110-113.
14. Skikne BS, Punnonen K, Caldron PH, et al. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index. Am J Hematol. 2011;86(11):923-927.
15. Iron: deficiency and toxicity. http://www.drhoffman.com/page.cfm/120).
16. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89(3):1052-1057.
17. Galanello R, Raffaella O. Thalassemia. Orphanet J Rare Dis. 2010;5:11 (http://www.ojrd.com/content/5/1/11).
18. Raya G, Henny J, Steinmetz J, Herbeth B, Siest G. Soluble transferrin receptor (sTfR): biological variations and reference limits. Clin Chem Lab Med. 2001;39(11):1162-1168.
19. Karlsson T. Comparative evaluation of the reticulocyte hemoglobin content assay when screening for iron deficiency in elderly anemic patients. Anemia. 2011;2011 (http://www.hindawi.com/journals/ane/2011/925907/).
20. Lopez-Sierra M, Calderón S, Gomez J, Pilleux L. Prevalence of anaemia and evaluation of transferrin receptor (stfr) in the diagnosis of iron deficiency in the hospitalized elderly patients: anaemia clinical studies in Chile. Anemia. 2012;2012 (http://www.hindawi.com/journals/ane/2012/646201/).
21. Lee EJ, Oh E-J, Park Y-J, Lee HK, Kim BK. Soluble transferrin receptor (sTfR), ferritin, and sTfR/log ferritin index in anemic patients with nonhematologic malignancy and chronic inflammation. Clin Chem. 2002;48(7):1118-1121.
22. Feelders RA, Kuiper-Kramer EP, van Eijk HG. Structure, function and clinical significance of transferrin receptors. Clin Chem Lab Med. 1999;37(1):1-10.
23. Kehrer JP. The Haber-Weiss reaction and mechanisms of toxicity. Toxicology. 2000;149(1):43-50.