Predicting drug penetration across the blood-brain barrier: Comparison of micellar liquid chromatography and immobilized artificial membrane liquid chromatography

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 18, 2013, Pages 6029-6041

  De Vrieze, Mike ^a   Lynen, Frédéric ^a   Chen, Kai ^a   Szucs, Roman ^b   Sandra, Pat ^a,c  

^a GHENT UNIVERSITY   (Belgium)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c Belgian Research Institute for Chromatography   (Belgium)

Author keywords

Blood brain barrier; Central nervous system; Immobilized artificial membrane; Micellar liquid chromatography; Modeling

Indexed keywords

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; CONSTRUCTION OF MODELS; IMMOBILIZED ARTIFICIAL MEMBRANES; MICELLAR LIQUID CHROMATOGRAPHY; PHOSPHATE-BUFFERED SALINES; POLYOXYETHYLENE (23) LAURYL ETHER (BRIJ-35); RELATIVE PERFORMANCE;

BLOOD; BRAIN MODELS; FORECASTING; MODELS; NEUROPHYSIOLOGY; POLYETHYLENE OXIDES; SODIUM DODECYL SULFATE;

LIQUID CHROMATOGRAPHY;

BUFFER; DODECYL SULFATE SODIUM; MACROGOL DERIVATIVE; SURFACTANT;

ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; CHEMISTRY; COMPARATIVE STUDY; COMPUTER PROGRAM; CONFERENCE PAPER; EQUIPMENT; HUMAN; LIQUID CHROMATOGRAPHY; METHODOLOGY; MICELLE; PHARMACOLOGY; REGRESSION ANALYSIS; THEORETICAL MODEL;

BLOOD-BRAIN BARRIER; BUFFERS; CHROMATOGRAPHY, LIQUID; HUMANS; LEAST-SQUARES ANALYSIS; MEMBRANES, ARTIFICIAL; MICELLES; MODELS, THEORETICAL; PHARMACOLOGICAL PROCESSES; POLYETHYLENE GLYCOLS; SODIUM DODECYL SULFATE; SOFTWARE; SURFACE-ACTIVE AGENTS;

EID: 84879797928     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7015-x     Document Type: Conference Paper

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