The protective effects of glutamine on radiation-induced diarrhea

Supportive Care in Cancer

Volumn 21, Issue 4, 2013, Pages 1071-1075

  Kucuktulu, Eda ^a   Guner, Ali ^a   Kahraman, Izzettin ^a   Topbas, Murat ^b   Kucuktulu, Uzer ^a  

^a Kanuni Training and Research Hospital ^*  (Turkey)

^b KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Diarrhea; Glutamine; Radiotherapy

Indexed keywords

GLUTAMINE; LOPERAMIDE; PLACEBO;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; GYNECOLOGIC CANCER; HUMAN; INCIDENCE; MALE; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; RADIATION HAZARD; RADIATION INDUCED DIARRHEA; RECTUM CANCER; SOFT TISSUE SARCOMA; TREATMENT OUTCOME;

AGED; ANTIDIARRHEALS; DIARRHEA; FEMALE; GLUTAMINE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; TURKEY;

EID: 84879795964     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-012-1627-0     Document Type: Article

References (31)

1. Labow BI, Souba WW (2000) Glutamine. World J Surg 24:504-513
2. Lacey J, Wilmore D (1990) Is glutamine a conditionally essential amino acid? Nutr Rev 48:297-309
3. Kapadia C, Muhlbacher F, Smith R (1982) Alterations in glutamine metabolism in response to operative stress and food deprivation. Surg Forum 33:19-21
4. Savarese DM, Savy G, Vahdat L et al (2003) Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev 29:501-513
5. Klimberg VS, Souba WW, Dolson DJ et al (1990) Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 66:62-68
6. Klimberg VS, Salloum RM, Kasper M et al (1990) Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Arch Surg 125:1040-1045
7. Jensen JC, Schaefer R, Nwokedi E et al (1994) Prevention of chronic radiation enteropathy by dietary glutamine. Ann Surg Oncol 1:157-163
8. Nagata Y, Lee CKK, Anderson PM, et al. (1995) Reduction of radiation damage in small intestine of rats by glutamine. In: Program and Abstracts of the 43rd Annual Meeting of the Radiation Research Society, 15th Annual Meeting of the North American Hyperthermia Society, San Jose, 1-6 April 1995.
9. Kaya E, Gur ES, Özguc H et al (1999) L-glutamine enemas attenuate mucosal injury in experimental colitis. Dis Colon Rectum 42:1209-1215
10. Scheppach W, Dusel G, Kuhn T et al (1996) Effect of L-glutamine and n-butyrate on the restitution of rat colonic mucosa after acid induced injury. Gut 38:878-885
11. DeCosse JJ, Rhodes RD, Wentz WB et al (1969) The natural history and management of radiation induced injury of the gastrointestinal tract. Ann Surg 170:369-373
12. Guzman G, Bonsack M, Liberty J et al (1989) Abdominal radiation causes bacterial translocation. J Surg Res 46:104-107
13. Miller RC, Martenson JA, Sargent DJ et al (1998) Acute treatment-related diarrhea during postoperative adjuvant therapy for high-risk rectal carcinoma. Int J Radiat Oncol Biol Phys 41:593-598
14. Kozelsky TF, Meyers GE, Sloan JA et al (2003) Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol 21:1669-1674
15. Daniele B, Perrone F, Gallo C et al (2001) Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomized trial. Gut 48:28-33
16. Wilmore DW, Shabert JK (1998) Role of glutamine in immunologic responses. Nutrition 14:618-626
17. Parry-Billigs M, Evans J, Calder PC et al (1990) Does glutamine contribute to immunosuppression after major burns? Lancet 336:523-525
18. Roth E, Funovics J, Muhlbacher F et al (1982) Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle. Clin Nutr 1:25-41
19. Oudemans-van Straaten HM, Bomsan RJ, Treskes M et al (2011) Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med 27:84-90
20. Tremel H, Kienle B, Weilemann LS et al (1994) Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 107:1595-1601
21. Buchman AL, Moukarzel AA, Bhuta S et al (1995) Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. JPEN J Parenter Enteral Nutr 19:453-460
22. Van der Julst RRWJ, Van Krell BK, Meyenfeldt V et al (1993) Glutamine and the preservation of gut integrity. Lancet 334:1363
23. Richards EW, Long CL, Pinkston JA, et al (1992) The role of oral glutamine supplementation in the prevention of radiation-induced enterocolitis in prostate cancer patients. FASEB J 6:A 1680 [abstract]
24. Hall JC, Heel K, McCauley R (1996) Glutamine. Br J Surg 83:305-312
25. Windmueller H (1982) Glutamine utilization by the small intestine. Adv Enzymol 53:201-237
26. Panigrahi P, Gewolb I, Bamford P et al (1997) Role of glutamine in bacterial transcytosis and epithelial cell injury. JPEN 21:75-80
27. Martenson JA, Hyland G, Moertel CG et al (1996) Olsalazine is contraindicated during pelvic radiation therapy: results of a double-blind, randomized clinical trial. Int J Radiat Oncol Biol Phys 35:299-303
28. Crook J, Esche B, Futter N (1996) Effect of pelvic radiotherapy prostate cancer on bowel, bladder and sexual function: the patient's perspective. Urology 47:387-394
29. Minsky BD, Conti JA, Huang Y et al (1995) Relationship of acute gastrointestinal toxicity and the volume of irradiated small bowel in patients receiving combined modality therapy for rectal cancer. J Clin Oncol 13:1409-1416
30. Potish RA, Jones TK Jr, Levitt SH (1979) Factors predisposing to radiation-related small-bowel damage. Radiology 132:479-482
31. Pilepich MV, Kral JM, Sause WT et al (1987) Correlation of radiotherapeutic parameters and treatment related morbidity in carcinoma of the prostate: analysis of RTOG study 75-06. Int J Radiat Oncol Biol Phys 13:351-357