The effects of vitamin D3 supplementation on serum total 25[OH]D concentration and physical performance: A randomised dose-response study

British Journal of Sports Medicine

Volumn 47, Issue 11, 2013, Pages 692-696

  Close, Graeme L ^a   Leckey, Jill ^a   Patterson, Marcelle ^a   Bradley, Warren ^a   Owens, Daniel J ^a   Fraser, William D ^b   Morton, James P ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; 25-HYDROXYVITAMIN D; COLECALCIFEROL; DRUG DERIVATIVE; VITAMIN; VITAMIN D;

ARTICLE; ATHLETIC PERFORMANCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; EXERCISE TEST; HUMAN; METABOLISM; MUSCLE METABOLISM; NUTRITION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPORTS AND NUTRITION; SUPPLEMENTS; YOUNG ADULT; ANALOGS AND DERIVATIVES;

MUSCLE METABOLISM; NUTRITION; SPORTS AND NUTRITION; SUPPLEMENTS;

ATHLETIC PERFORMANCE; CHOLECALCIFEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXERCISE TEST; HUMANS; VITAMIN D; VITAMINS; YOUNG ADULT;

EID: 84879795866     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2012-091735     Document Type: Article

References (57)

1. Dirks-Naylor AJ, Lennon-Edwards S. The effects of vitamin D on skeletal muscle function and cellular signaling. J Steroid Biochem Mol Biol 2011;125: 159-68.
2. Walters MR. Newly identified actions of the vitamin D endocrine system. Endocr Rev 1992;13: 719-64. (Pubitemid 23037213)
3. Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008;13: 6-20. (Pubitemid 351489580)
4. Simpson RU, Thomas GA, Arnold AJ. Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem 1985;260: 8882-91. (Pubitemid 15011982)
5. Pfeifer M, Begerow B, Minne HW. Vitamin D and muscle function. Osteoporos Int 2002;13: 187-94. (Pubitemid 34408183)
6. Rimaniol JM, Authier FJ, Chariot P. Muscle weakness in intensive care patients: initial manifestation of vitamin D deficiency. Intensive Care Med 1994;20: 591-2. (Pubitemid 24364940)
7. Ziambaras K, Dagogo-Jack S. Reversible muscle weakness in patients with vitamin D deficiency. West J Med 1997;167: 435-9. (Pubitemid 128752619)
8. Prabhala A, Garg R, Dandona P. Severe myopathy associated with vitamin D deficiency in western New York. Arch Intern Med 2000;160: 1199-203. (Pubitemid 30227032)
9. Irani PF. Electromyography in nutritional osteomalacic myopathy. J Neurol Neurosurg Psychiatry 1976;39: 686-93.
10. Sato Y, Iwamoto J, Kanoko T, et al. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis 2005;20: 187-92. (Pubitemid 41254180)
11. Sedrani SH. Vitamin D status of Saudi men. Trop Geogr Med 1984;36: 181-7. (Pubitemid 15203350)
12. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997;7: 439-43. (Pubitemid 27443069)
13. Lamberg-Allardt CJ, Outila TA, Karkkainen MU, et al. Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? J Bone Miner Res 2001;16: 2066-73. (Pubitemid 32995398)
14. McGrath JJ, Kimlin MG, Saha S, et al. Vitamin D insufficiency in south-east Queensland. Med J Aust 2001;174: 150-1. (Pubitemid 32149364)
15. Ward KA, Das G, Roberts SA, et al. A randomized, controlled trial of vitamin D supplementation upon musculoskeletal health in postmenarchal females. J Clin Endocrinol Metab 2010;95: 4643-51.
16. Lehtonen-Veromaa M, Mottonen T, Irjala K, et al. Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls. Eur J Clin Nutr 1999;53: 746-51. (Pubitemid 29424006)
17. Ducher G, Kukuljan S, Hill B, et al. Vitamin D status and musculoskeletal health in adolescent male ballet dancers a pilot study. J Dance Med Sci 2011;15: 99-107.
18. Hamilton B, Grantham J, Racinais S, et al. Vitamin D deficiency is endemic in Middle Eastern sportsmen. Public Health Nutr 2010;13: 1528-34.
19. Halliday TM, Peterson NJ, Thomas JJ, et al. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med Sci Sports Exerc 2011;43: 335-43.
20. Lovell G. Vitamin D status of females in an elite gymnastics program. Clin J Sport Med 2008;18: 159-61. (Pubitemid 351365723)
21. Morton JP, Iqbal Z, Drust B, et al. Seasonal variation in vitamin D status in professional soccer players of the English Premier League. Appl Physiol Nutr Metab 2012;37: 798-802.
22. Bescos Garcia R, Rodriguez Guisado FA. Low levels of vitamin D in professional basketball players after wintertime: relationship with dietary intake of vitamin D and calcium. Nutr Hosp 2011;26: 945-51.
23. Close GL, Russell J, Cobley JN, et al. Assessment of vitamin D concentration in professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci 2012.
24. Wilson G, Fraser WD, Sharma A, et al. Markers of bone health, renal function, liver function, anthropometry and perception of mood: a comparison between Flat & National Hunt jockeys. Int J Sports Med 2012.
25. Willis KS, Peterson NJ, Larson-Meyer DE. Should we be concerned about the vitamin D status of athletes? Int J Sport Nutr Exerc Metab 2008;18: 204-24.
26. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135: 317-22. (Pubitemid 40194499)
27. Gillie O. Sunlight robbery: a critique of public health policy on vitamin D in the UK. Mol Nutr Food Res 2010;54: 1148-63.
28. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80(6 Suppl):1678S-88S.
29. Barger-Lux MJ, Heaney RP. Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab 2002;87: 4952-6. (Pubitemid 35316331)
30. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003;89: 552-72. (Pubitemid 36592083)
31. Glendenning P, Noble JM, Taranto M, et al. Issues of methodology, standardization and metabolite recognition for 25-hydroxyvitamin D when comparing the diasorin radioimmunoassay and the nichols advantage automated chemiluminescence protein-binding assay in hip fracture cases. Ann Clin Biochem 2003;40(Pt 5): 546-51. (Pubitemid 37152208)
32. Holick MF. 25-OH-vitamin D assays. J Clin Endocrinol Metab 2005;90: 3128-9.
33. Fraser WD. Standardization of vitamin D assays: art or science? Ann Clin Biochem 2009;46(Pt 1): 3-4.
34. Glendenning P, Taranto M, Noble JM, et al. Current assays overestimate 25-hydroxyvitamin D3 and underestimate 25-hydroxyvitamin D2 compared with HPLC: need for assay-specific decision limits and metabolite-specific assays. Ann Clin Biochem 2006;43(Pt 1): 23-30. (Pubitemid 43105054)
35. Cashman KD, Hill TR, Lucey AJ, et al. Estimation of the dietary requirement for vitamin D in healthy adults. Am J Clin Nutr 2008;88: 1535-42.
36. Heaney RP, Davies KM, Chen TC, et al. Human serum 25- hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77: 204-10. (Pubitemid 36015393)
37. Holick MF. McCollum Award Lecture, 1994: vitamin D - new horizons for the 21st century. Am J Clin Nutr 1994;60: 619-30.
38. Batterham AM, Atkinson G. How big does my sample need to be? A primer on the murky world of sample size estimation. Phys Ther Sport 2005;6: 153-63. (Pubitemid 41150121)
39. Atkinson G. What is this thing called measurement error? In: Reilly T, Marfell-Jones M eds. Kinanthropometry VIII: Proceedings of the 8th International Conference of the International Society for the Advancement of Kinanthropometry (ISAK). London: Taylor and Francis, 2003, 3-14.
40. Maxwell SE, Delaney HD. Designing experiments and analyzing data: a model comparison perspective. 2nd edn. Mahwah, NJ: Lawrence Erlbaum Associates, 2004.
41. Morton JP, Iqbal Z, Drust B, et al. Seasonal variation in vitamin D status in professional soccer players of the English premier league. Appl Physiol Nutr Metab 2012;37: 798-802.
42. Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr 2007;85: 649-50. (Pubitemid 46393494)
43. Heaney RP. Assessing vitamin D status. Curr Opin Clin Nutr Metab Care 2011;14: 440-4.
44. Durup D, Jorgensen HL, Christensen J, et al. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice, the CopD study. J Clin Endocrinol Metab 2012;97: 2644-52.
45. Wagner D, Hanwell HE, Schnabl K, et al. The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. J Steroid Biochem Mol Biol 2011;126: 72-7.
46. Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect 2007;135: 1095-6.
47. Giovannucci E. Vitamin D and cardiovascular disease. Curr atheroscler Rep 2009;11: 456-61.
48. Lappe JM, Travers-Gustafson D, Davies KM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007;85: 1586-91. (Pubitemid 46890428)
49. Heaney RP, Dowell MS, Hale CA, et al. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22: 142-6. (Pubitemid 36417827)
50. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003;326:469.
51. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293: 2257-64. (Pubitemid 40629192)
52. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 2009;169: 551-61.
53. Biesalski HK, Aggett PJ, Anton R, et al. 26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: evidence-based nutrition. Nutrition 2011;27(Suppl 10):S 1-20.
54. Heaney RP, Holick MF. Why the IOM recommendations for vitamin D are deficient. J Bone Miner Res 2011;26: 455-7.
55. Close GL, Kayani A, Vasilaki A, et al. Skeletal muscle damage with exercise and aging. Sports Med 2005;35: 413-27. (Pubitemid 40806941)
56. Evans WJ. Skeletal muscle loss: cachexia, sarcopenia, and inactivity. Am J Clin Nutr 2010;91:1123S-7S.
57. Lynch GS. Sarcopenia - age related muscle wasting and weakness:mechanisms and treatments. 1st edn. London, UK: Springer-Verlag, 2011.