Mesenchymal Stem Cells Improve Medullary Inflammation and Fibrosis after Revascularization of Swine Atherosclerotic Renal Artery Stenosis

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Ebrahimi, Behzad ^a   Eirin, Alfonso ^a   Li, Zilun ^a,b   Zhu, Xiang Yang ^a   Zhang, Xin ^a   Lerman, Amir ^a   Textor, Stephen C ^a   Lerman, Lilach O ^a  

^a MAYO CLINIC   (United States)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FUROSEMIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADIPOSE TISSUE CELL; ANGIOGENESIS; ANGIOPLASTY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC RENAL ARTERY STENOSIS; BLOOD PRESSURE REGULATION; BOLD SIGNAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; KIDNEY ARTERY STENOSIS; KIDNEY BLOOD FLOW; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PARENCHYMA; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE DAMAGE; MESENCHYMAL STEM CELL TRANSPLANTATION; NEPHRITIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PERCUTANEOUS TRANSLUMINAL RENAL ANGIOPLASTY; PROTEIN EXPRESSION; REVASCULARIZATION; SIGNAL TRANSDUCTION; SWINE; TREATMENT RESPONSE;

ANGIOPLASTY; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ARGINASE; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; INFLAMMATION; KIDNEY; KIDNEY TUBULES, PROXIMAL; MACROPHAGES; MESENCHYMAL STEM CELL TRANSPLANTATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RENAL ARTERY OBSTRUCTION; SWINE;

SUIDAE;

EID: 84879772568     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067474     Document Type: Article

References (33)

1. de Mast Q, Beutler JJ, (2009) The prevalence of atherosclerotic renal artery stenosis in risk groups: a systematic literature review. J Hypertens 27: 1333-1340.
2. Lerman LO, Textor SC, Grande JP, (2009) Mechanisms of tissue injury in renal artery stenosis: ischemia and beyond. Prog Cardiovasc Dis 52: 196-203.
3. Daghini E, Sanna M, Versari D, Di Paco I, Ghiadoni L, et al. (2010) Long Term Follow up of Hypertensive Patients with Atherosclerosis Renal Artery Stenosis after Percutaneous Renal Artery Angioplasty or Stenting: Blood Pressure Outcome. Journal of Hypertension 28: E210-E210.
4. Eirin A, Zhu XY, Urbieta-Caceres VH, Grande JP, Lerman A, et al. (2011) Persistent kidney dysfunction in swine renal artery stenosis correlates with outer cortical microvascular remodeling. Am J Physiol Renal Physiol 300: F1394-1401.
5. Wheatley K, Ives N, Gray R, Kalra PA, Moss JG, et al. (2009) Revascularization versus Medical Therapy for Renal-Artery Stenosis. New England Journal of Medicine 361: 1953-1962.
6. Cooper CJ, Murphy TP, Matsumoto A, Steffes M, Cohen DJ, et al. (2006) Stent revascularization for the prevention of cardiovascular and renal events among patients with renal artery stenosis and systolic hypertension: rationale and design of the CORAL trial. Am Heart J 152: 59-66.
7. Eirin A, Zhu XY, Krier JD, Tang H, Jordan KL, et al. (2012) Adipose tissue-derived mesenchymal stem cells improve revascularization outcomes to restore renal function in swine atherosclerotic renal artery stenosis. Stem Cells 30: 1030-1041.
8. Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, et al. (2009) Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Circulation 119: 547-557.
9. Chade AR, Zhu XY, Krier JD, Jordan KL, Textor SC, et al. (2010) Endothelial progenitor cells homing and renal repair in experimental renovascular disease. Stem Cells 28: 1039-1047.
10. Ebrahimi B, Li Z, Eirin A, Zhu XY, Textor SC, et al. (2012) Addition of endothelial progenitor cells to renal revascularization restores medullary tubular oxygen consumption in swine renal artery stenosis. Am J Physiol Renal Physiol 302: F1478-1485.
11. Herrera MB, Bussolati B, Bruno S, Fonsato V, Romanazzi GM, et al. (2004) Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med 14: 1035-1041.
12. Togel F, Hu Z, Weiss K, Isaac J, Lange C, et al. (2005) Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol 289: F31-42.
13. Zhu XY, Urbieta-Caceres V, Krier JD, Textor SC, Lerman A, et al. (2013) Mesenchymal Stem Cells and Endothelial Progenitor Cells Decrease Renal Injury in Experimental Swine Renal Artery Stenosis Through Different Mechanisms. Stem Cells 31: 117-125.
14. Semedo P, Wang PM, Andreucci TH, Cenedeze MA, Teixeira VP, et al. (2007) Mesenchymal stem cells ameliorate tissue damages triggered by renal ischemia and reperfusion injury. Transplant Proc 39: 421-423.
15. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, et al. (2004) Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15: 1794-1804.
16. Semedo P, Correa-Costa M, Cenedeze MA, Malheiros DMAC, dos Reis MA, et al. (2009) Mesenchymal Stem Cells Attenuate Renal Fibrosis Through Immune Modulation and Remodeling Properties in a Rat Remnant Kidney Model. Stem Cells 27: 3063-3073.
17. Lerman LO, Schwartz RS, Grande JP, Sheedy PF, Romero JC, (1999) Noninvasive evaluation of a novel swine model of renal artery stenosis. J Am Soc Nephrol 10: 1455-1465.
18. Urbieta-Caceres VH, Lavi R, Zhu XY, Crane JA, Textor SC, et al. (2010) Early atherosclerosis aggravates the effect of renal artery stenosis on the swine kidney. Am J Physiol Renal Physiol 299: F135-140.
19. Favreau F, Zhu XY, Krier JD, Lin J, Warner L, et al. (2010) Revascularization of swine renal artery stenosis improves renal function but not the changes in vascular structure. Kidney Int 78: 1110-1118.
20. Warner L, Glockner JF, Woollard J, Textor SC, Romero JC, et al. (2011) Determinations of renal cortical and medullary oxygenation using blood oxygen level-dependent magnetic resonance imaging and selective diuretics. Invest Radiol 46: 41-47.
21. Daghini E, Primak AN, Chade AR, Krier JD, Zhu XY, et al. (2007) Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT. Radiology 243: 405-412.
22. Krier JD, Ritman EL, Bajzer Z, Romero JC, Lerman A, et al. (2001) Noninvasive measurement of concurrent single-kidney perfusion, glomerular filtration, and tubular function. Am J Physiol Renal Physiol 281: F630-638.
23. Marigo I, Dazzi F, (2011) The immunomodulatory properties of mesenchymal stem cells. Semin Immunopathol 33: 593-602.
24. Ebrahimi B, Gloviczki M, Woollard JR, Crane JA, Textor SC, et al. (2012) Compartmental analysis of renal BOLD MRI data: Introduction and validation. Invest Radiol 47: 175-182.
25. Ward WK, Quinn MJ, Wood MD, Tiekotter KL, Pidikiti S, et al. (2003) Vascularizing the tissue surrounding a model biosensor: how localized is the effect of a subcutaneous infusion of vascular endothelial growth factor (VEGF)? Biosens Bioelectron 19: 155-163.
26. Eirin A, Li Z, Zhang X, Krier JD, Woollard JR, et al. (2012) A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis. Hypertension 60: 1242-1249.
27. Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW Jr, (2002) Increased renal medullary oxidative stress produces hypertension. Hypertension 39: 667-672.
28. Mori T, Cowley AW Jr, (2003) Angiotensin II-NAD(P)H oxidase-stimulated superoxide modifies tubulovascular nitric oxide cross-talk in renal outer medulla. Hypertension 42: 588-593.
29. Mori T, Cowley AW, (2004) Renal oxidative stress in medullary thick ascending limbs produced by elevated NaCl and glucose. Hypertension 43: 341-346.
30. Bruno S, Grange C, Deregibus MC, Calogero RA, Saviozzi S, et al. (2009) Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury. Journal of the American Society of Nephrology 20: 1053-1067.
31. Gatti S, Bruno S, Deregibus MC, Sordi A, Cantaluppi V, et al. (2011) Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol Dial Transplant 26: 1474-1483.
32. Timmers L, Lim SK, Arslan F, Armstrong JS, Hoefer IE, et al. (2007) Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium. Stem Cell Res 1: 129-137.
33. Biancone L, Bruno S, Deregibus MC, Tetta C, Camussi G, (2012) Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrology Dialysis Transplantation 27: 3037-3042.