Slow accrual of elderly patients with metastatic breast cancer in the Dutch multicentre OMEGA study

Breast

Volumn 22, Issue 4, 2013, Pages 556-559

  Hamaker, M E ^a   Seynaeve, C ^b   Nortier, J W R ^c   Wymenga, M ^d   Maartense, E ^e   Boven, E ^f   van Leeuwen Stok, A E ^g   de Rooij, S E ^h   van Munster, B C ^h,i   Smorenburg, C H ^j  

^a DEPARTMENT OF SURGERY   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MEDISCH SPECTRUM TWENTE   (Netherlands)

^e REINIER DE GRAAF HOSPITAL   (Netherlands)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^g Dutch Breast Cancer Trialists' Group BOOG   (Netherlands)

^h ACADEMIC MEDICAL CENTER   (Netherlands)

ⁱ GELRE HOSPITALS   (Netherlands)

^j Location Alkmaar   (Netherlands)

more..

Author keywords

Accrual; Clinical trials; Elderly; Metastatic breast cancer

Indexed keywords

AGED; ARTICLE; BREAST CANCER; CANCER PATIENT; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GERIATRIC PATIENT; HEART FUNCTION; HUMAN; LIFE EXPECTANCY; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTICENTER STUDY; PATIENT EDUCATION; PATIENT PARTICIPATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT REFUSAL;

EID: 84879735866     PISSN: 09609776     EISSN: 15323080     Source Type: Journal    
DOI: 10.1016/j.breast.2012.12.010     Document Type: Article

References (17)

1. Hutchins L.F., Unger J.M., Crowley J.J., Coltman C.A., Albain K.S. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. NEngl J Med 1999, 341(27):2061-2067.
2. Scher K.S., Hurria A. Under-representation of older adults in cancer registration trials: known problem, little progress. JClin Oncol 2012, 30(17):2036-2038.
3. Wildiers H., Kunkler I., Biganzoli L., Fracheboud J., Vlastos G., Bernard-Marty C., et al. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol 2007, 8(12):1101-1115.
4. Charlson M.E., Pompei P., Ales K.L., Mackenzie C.R. Anew method of classifying prognostic comorbidity in longitudinal studies: development and validation. JChronic Dis 1987, 40(5):373-383.
5. Lawton M.P., Brody E.M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969, 9(3):179-186.
6. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res 1975, 12(3):189-198.
7. Sheikh J.I., Yesavage J.A., Brooks J.O., Friedman L., Gratzinger P., Hill R.D., et al. Proposed factor structure of the geriatric depression scale. Int Psychogeriatr 1991, 3(1):23-28.
8. Slaets J.P. Vulnerability in the elderly: frailty. Med Clin North Am 2006, 90(4):593-601.
9. Ferrucci L., Guralnik J.M., Studenski S., Fried L.P., Cutler G.B., Walston J.D. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. JAm Geriatr Soc 2004, 52(4):625-634.
10. ten Tije A.J., Smorenburg C.H., Seynaeve C., Sparreboom A., Schothorst K.L., Kerkhofs L.G., et al. Weekly paclitaxel as first-line chemotherapy for elderly patients with metastatic breast cancer. A multicentre phase II trial. Eur J Cancer 2004, 40(3):352-357.
11. Maas H.A., Janssen-Heijnen M.L., Olde Rikkert M.G., Machteld Wymenga A.N. Comprehensive geriatric assessment and its clinical impact in oncology. Eur J Cancer 2007, 43(15):2161-2169.
12. Reed M.W., Wyld L., Ellis P., Bliss J., Leonard R. Breast cancer in older women: trials and tribulations. Clin Oncol (R Coll Radiol ) 2009, 21(2):99-102.
13. Leonard R., Ballinger R., Cameron D., Ellis P., Fallowfield L., Gosney M., et al. Adjuvant chemotherapy in older women (ACTION) study - what did we learn from the pilot phase?. Br J Cancer 2011, 105(9):1260-1266.
14. Liu G., Franssen E., Fitch M.I., Warner E. Patient preferences for oral versus intravenous palliative chemotherapy. JClin Oncol 1997, 15(1):110-115.
15. Audisio R.A., Van L.B. When reporting on older patients with cancer, frailty information is needed. Ann Surg Oncol 2011, 18(1):4-5. Date of Publication: January 2011(1):January.
16. Townsley C.A., Chan K.K., Pond G.R., Marquez C., Siu L.L., Straus S.E. Understanding the attitudes of the elderly towards enrolment into cancer clinical trials. BMC Cancer 2006, 6:34.
17. Wright J.R., Whelan T.J., Schiff S., Dubois S., Crooks D., Haines P.T., et al. Why cancer patients enter randomized clinical trials: exploring the factors that influence their decision. JClin Oncol 2004, 22(21):4312-4318.