Antihepatotoxic, nephroprotective, and antioxidant activities of phenolic compounds from Satureja macrostema leaves against carbon tetrachloride-induced hepatic damage in mice

Medicinal Chemistry Research

Volumn 22, Issue 4, 2013, Pages 1846-1855

  Gutierrez, Rosa Martha Perez ^a  

^a INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Flavonoids glycosides; Hepatoprotective activity; Kidney protective; Satureja macrostema

Indexed keywords

4' METHOXY 5,7,3' TETRA HYDROXY FLAVANONE 3 O BETA D RHAMNOPYRANOSYL (1 2) BETA D RHAMNOPYRANOSIDE; 5 HYDROXY 3,6,4' TRIMETHOXYFLAVONOL 7 C ALPHA L RHAMNIPYRANOSYL (1 3) BETA D GLUCOPYRANOSIDE; 5 HYDROXY 7,4' DIMETHOXYFLAVONE; 5,3',4',5' TETRAHYDROXYFLAVANONE 7 O BETA D RHAMNOPYRANOSIDE; 5,3',4',5' TETRAMETHOXYFLAVANONE 7 O BETA D RHAMNOPYRANOSIDE; 5,4' DIMETHOXY 3' HYDROXYFLAVONE 7 BETA D RHAMNOPYRANOSIDE; 5,4' DIMETHOXY 7,3',5' TRIHYDROXYFLAVANONE 2 O BETA D RHAMNOPYRANOSIDE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CATALASE; CHOLESTEROL; CREATININE; DIOSMIN; FLAVONOID GLYCOSIDE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; MALONALDEHYDE; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN; PRUNIN; SATUREJA MACROSTEMA EXTRACT; SILYMARIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; KIDNEY FUNCTION; KIDNEY INJURY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; RAT; RENAL PROTECTION; SATUREJA MACROSTEMA; SAVORY; UREA BLOOD LEVEL;

EID: 84879689395     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0176-x     Document Type: Article

References (27)

1. Aguilar RM (2001) Fenologia del te nurite (Satureja macrostema (Benth.) Bricq.). In: Memoria de la reunion interamericana de ciencias horticolas. 8, 284
2. Baek NL, Kim YS, Kyung JS, Park KH (1996) Isolation of anti-hepatotoxic agent from the roots of Astragalus membranaceous. Korean J Pharmacogn 27:111-116
3. Brenini B, Chulia AJ, Kaouadji M, Thomasson F (1988) Flavonoid glycosides from Erica cinerea. Phytochemistry 31:2483-2486
4. D'Agostino M, De Feo V, De Simone F, Vincieri FF, Pizza C (1989) Isolation of 8-Hydroxy-5,7,3′,4′-tetramethoxy-4-phenylcoumarin from Coutarea hexandra. Planta Med 55:578-5580
5. Dorkina EG (2004) Investigation of the hepatoprotector action of natural flavonoids. Eksp Klin Farmakol 67:41-42
6. Erez A, Lavee S (1969) Prunin identification, biological activity and quantitative change in comparison to naringenin in dormant peach buds. Plant Physiol 44:342-346
7. Espejo A, Lopez-Ferrari AR (1998) Las monocotiledóneas mexicanas una sinopsis florística 1. Consejo nacional de la flora de México, A.C., Universidad Autónoma Metroplitana-Iztapalapa, comisión nacional para el conocimiento y uso de la biodiversidad. México, pp 235-241
8. Gaffield W, Lundin RE, Gentili BR, Horowitz M (1975) C-2 stereochemistry of naringin and its relation to taste and biosynthesis in maturing grapefruit. Bioorg Chem 4:259-269
9. Kokkalou E, Kapetanidis I (1988) Flavonoids and phenolic acids in Salvia horminus L. (Lamiaceae). Pharm Acta Helv 63:90-92
10. Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H (2004) Antioxidant and free radical-scavenging activity of choto-san and its related constituents. Biol Pharm Bull 27:38-46
11. Martini ND, Katerere DR, Eloff JN (2004) Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae). J Ethnopharmacol 93:207-212
12. Matsuda H, Nishida N, Yoshikawa M (2002) Antidiabetic principles of natural medicines. Aldose reductase inhibitors from Myrcia multiflora DC. (2): of structures myrciacitrins III, IV and V. Chem Pharm Bull 50:429-431
13. Miller NJ, Rice-Evans C (1997) Factors influencing the antioxidant activity determined by the ABTS radical cation assay. Free Radic Res 26:195-199
14. Moure A, Cruz JM, Franco D, Dominguez JM, Sineiro J, Dominguez H (2001) Natural antioxidants from residual sources. Food Chem 72:145-171
15. Nishikimi M, Appaji N, Yagi K (1972) The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 46:849-853
16. Ohkawa H, Onishi M, Yagi K (1979) Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction. Anal Biochem 95:351-358
17. Ozturk F, Ucar M, Ozturk IC, Vardi N, Batcioglu K (2003) Carbon tetrachloride- induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats. Urology 62:353-356
18. Pajero VL, Codina C, Petrakis C, Kefalas P (2000) Evaluation of scavenging activity assessed by Co(II)/EDTA-induced luminal chemiluminescence and DPPH (2,2-diphenyl-1 picryl-hydrazyl) free radical assay. J Pharmacol Toxicol Methods 44:507-512
19. Perez GRM, Gallardo NYT (2010) Antioxidant and hepatoprotective effects of methanol extract of leaves of Satureja Macrostema. Phcog Mag 6:125-131
20. Perez AL, Courel M, Sobrado J, Gonzalez L (1987) Acute renal failure after topical application of carbon tetrachloride. Lancet 1:515-516
21. 13C-NMR assignments of its acetyl derivative. Fitoterapia 66:471-472
22. Sallie R, Tredger JM, William R (1991) Drug and the liver. Biopharm Drug Disp 12:251-259
23. Sekiya N, Hikiami H, Nakai Y, sakakibara I, Nozaki K, Kouta K, Shimada Y, Terasawa K (2005) Inhibitory effect of triterpenes isolated from chuling (Polyporus umbellatus fries) on free radical-induced lysis of red blood cells. Biol Pharm Bull 25:817-821
24. Soicke H, Leng-Peschlow E (1977) Characterisation of flavonoids from Baccharis trimera and their antihepatotoxic properties. Planta Med 39:37-39
25. Upadhay R, Pandey ND, Narvi SS, Verma A, Ahmed B (2010) Antihepatotoxic effect of Feronia limonia fruit against carbon tetrachloride induced hepatic damage in albino rats. Chinese Med 1:18-22
26. 4)-induced acute liver failure. Pharm Res 26:893-902
27. Yoshizaki M, Fujino H, Masuyama M, Arisawa M, Morita N (1987) A chemotaxonomic study of flavonoids in the leaves of six Trichosanthes species. Phytochemistry 25:57-59