In vivo antidiabetic activity and in silico studies on adenosine monophosphate-activated protein kinase (AMPK) of (2E,5E)-2,5-bis(4-hydroxy-3- methoxybenzylidene) cyclopentanone

Medicinal Chemistry Research

Volumn 22, Issue 5, 2013, Pages 2430-2436

  Raj, Chenna Govindaraju Darshan ^a   Sarojini, Balladka Kunhanna ^a   Khan, Mahmud Tareq Hassan ^b   Raghavendra, Ramappa ^c  

^a P A COLLEGE OF ENGINEERING   (India)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c KUVEMPU UNIVERSITY   (India)

Author keywords

AMPK; Antidiabetes; Antihyperglycemic; Bischalcone derivative

Indexed keywords

2,5BIS(4 HYDROXY 3 METHOXYBENZYLIDENE) CYCLOPENTANONE; ADENOSINE PHOSPHATE; ADENYLATE KINASE; ANTIDIABETIC AGENT; CYCLOPENTANONE DERIVATIVE; GLIBENCLAMIDE; GLUCOSE; STREPTOZOCIN; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; IN VIVO STUDY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STREPTOZOCIN DIABETES;

EID: 84879688358     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0237-1     Document Type: Article

References (24)

1. Abagyan RA, Totrov MM, Kuznetsov DA (1994) ICM: a new method for protein modeling and design: applications to docking and structure prediction from the distorted native conformation. J Comput Chem 15:488-506
2. Anusuya S, Venugopal PM (2003) Protection of pancreatic β-cell by the potential antioxidant bis-ohydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. J Pharm Pharm Sci 6:327-333
3. Arie G, Gali B, Shlomo S (2009) Adenosine monophosphate-activated protein kinase (ampk) as a new target for antidiabetic drugs: a review on metabolic, pharmacological and chemical considerations. Rev Diabetes Stud 6:13-36
4. Butcher RJ, Jasinski JP, Narayana B, Sarojini BK, Bindya S, Yathirajan HS (2007) 2,5-Bis(3,4-dimethoxybenzylidene)cyclopentanone. Acta Cryst E 63:o3270-o3271
5. Furniss BS, Hannaford AJ, Smith PWG, Tatchell AR (1989) Vogel's text book of practical organic chemistry, 5th edn. Longman Group UK Ltd., London, p 1034
6. Habbu PV, Mahadevan KM, Kulkarni PV, Daultsingh C, Veerapur VP, Shastry RA (2010) Adaptogenic and in vitro antioxidant activity of argyreia speciosa (burm.f) boj. in acute and chronic stress paradigms in rodents. Indian J Exp Biol 48:53-60
7. Halgren TA (1996a) Merck molecular force field. II. MMFF94 van der Waals and electrostatic parameters for intermolecular interactions. J Comput Chem 17:520-552
8. Halgren TA (1996b) Merck molecular force field. III. Molecular geometries and vibrational frequencies. J Comput Chem 17:553-586
9. Halgren TA (1996c) Merck molecular force field. V. Extension of MMFF94 using experimental data, additional computational data and empirical rules. J Comput Chem 17:616-641
10. Halgren TA (1999a) MMFF VI. MMFF94s option for energy minimization studies. J Comput Chem 20:720-729
11. Halgren TA (1999b) MMFF VII characterization of MMFF94, MMFF94s, and other widely available force fields for conformational energies and for intermolecular-interaction energies and geometries. J Comput Chem 20:730-748
12. Halgren TA, Nachbar RB (1996) Merck molecular force field. IV. Conformational energies and geometries for MMFF94. J Comput Chem 17:587-615
13. Kasiviswanath R, Ramesh A, Kumar KE (2005) Hypoglycemic and antihyperglycemic effect of Gmelina asiatica Linn in normal and alloxan induced diabetic rats. Biol Pharm Bull 28:729-732
14. Khan MT, Fuskevag OM, Sylte I (2009) Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays. J Med Chem 52:48-61
15. Lernmark A, Ott J (1998) Sometimes it's hot. Sometimes its not. Nat Genet 19:213-218
16. Matti R, Das UK, Ghosh D (2005) Attenuation of hyperglycemia and hyperlipidemia in streptozotocin induced diabetic rats by aqueous CA of seed of Tamarindus indica. Biol Pharm Bull 28:1172-1176
17. Natchaya W, Pattarin S, Amporn J, Apichart S, Suthiluk P (2009) Effects of curcumin and tetrahydrocurcumin on diabetes induced endothelial dysfunction. Afr J Biochem Res 3:259-265
18. Pathak RM, Ansari S, Mahnood A (1981) Changes in chemical composition of intestinal brush border membrane in alloxan induced chronic diabetes. Indian J Exp Biol 9:503-505
19. Preetha A, Chitra S, Sonia J, Ajaikumar BK, Bharat B (2008) Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett 267:133-164
20. Schapira M, Totrov M, Abagyan R (1999) Prediction of the binding energy for small molecules, peptides and proteins. J Mol Recognit 12:177-190
21. Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G (2003) Hypoglycaemic and hypolipidemic effect of ethanolic CA of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 85:201-206
22. Siddique O, Sun Y, Lin JC, Chein YW (1987) Facilitated transdermal transport of insulin. J Pharmacol Sci 76:341-345
23. Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes. Diabetes Care 27:1047-1053
24. Yanardag R, Colak H (1998) Effect of chard (Beta vulgaris L. var. cicla) on blood glucose levels in normal and alloxan-induced diabetic rabbits. Pharm Pharmacol Commun 4:309-311