Neuregulin 3 and Erbb signalling networks in embryonic mammary gland development

Journal of Mammary Gland Biology and Neoplasia

Volumn 18, Issue 2, 2013, Pages 149-154

  Kogata, Naoko ^a   Zvelebil, Marketa ^a   Howard, Beatrice A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Erbb4; Mammary primordium; Network; Neuregulin 3 (Nrg3)

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GROWTH FACTOR; NEUREGULIN 3; UNCLASSIFIED DRUG;

BREAST CANCER; BREAST DEVELOPMENT; CELL FATE; CELL FUNCTION; EMBRYO DEVELOPMENT; GENE; MAMMARY GLAND; MOLECULAR BIOLOGY; MORPHOGENESIS; NONHUMAN; NRG3 GENE; PHENOTYPE; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MAMMARY GLANDS, ANIMAL; MAMMARY GLANDS, HUMAN; NEUREGULINS; ONCOGENE PROTEINS V-ERBB; SIGNAL TRANSDUCTION;

EID: 84879684536     PISSN: 10833021     EISSN: 15737039     Source Type: Journal    
DOI: 10.1007/s10911-013-9286-4     Document Type: Review

References (29)

1. Howard B, Panchal H, McCarthy A, Ashworth A. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005;19(17):2078-90. doi: 10.1101/gad.338505.
2. Cowin P, Wysolmerski J. Molecular mechanisms guiding embryonic mammary gland development. Cold Spring Harb Perspect Biol. 2010;2(6):a003251. doi: 10.1101/cshperspect.a003251.
3. Howard BA, Gusterson BA. The characterization of a mouse mutant that displays abnormal mammary gland development. Mamm Genome. 2000;11(3):234-7.
4. Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, et al. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997;94(18):9562-7.
5. Falls DL. Neuregulins: functions, forms, and signaling strategies. Exp Cell Res. 2003;284(1):14-30.
6. Hayes NV, Gullick WJ. The neuregulin family of genes and their multiple splice variants in breast cancer. J Mammary Gland Biol Neoplasia. 2008;13(2):205-14. doi: 10.1007/s10911-008-9078-4.
7. Bao J, Wolpowitz D, Role LW, Talmage DA. Back signaling by the Nrg-1 intracellular domain. J Cell Biol. 2003;161(6):1133-41. doi: 10.1083/jcb.200212085.
8. Graus-Porta D, Beerli RR, Daly JM, Hynes NE. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J. 1997;16(7):1647-55. doi: 10.1093/emboj/16.7.1647.
9. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23(1):112-22. doi: 10.1681/ASN.2011020160.
10. Wansbury O, Panchal H, James M, Parry S, Ashworth A, Howard B. Dynamic expression of Erbb pathway members during early mammary gland morphogenesis. J Invest Dermatol. 2008;128(4):1009-21. doi: 10.1038/sj.jid.5701118.
11. van Genderen C, Okamura RM, Farinas I, Quo RG, Parslow TG, Bruhn L, et al. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 1994;8(22):2691-703.
12. Boras-Granic K, Chang H, Grosschedl R, Hamel PA. Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol. 2006.
13. Panchal H, Wansbury O, Parry S, Ashworth A, Howard B. Neuregulin3 alters cell fate in the epidermis and mammary gland. BMC Dev Biol. 2007;7:105. doi: 10.1186/1471-213X-7-105.
14. Balinsky B. On the developmental processes in mammary glands and other epidermal structures. Transactions of the Royal Society Edinburgh. 1949-1950;62:1-31.
15. Balinsky BI. On the prenatal growth of the mammary gland rudiment in the mouse. J Anat. 1950;84(3):227-35.
16. Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell. 2012;10(2):183-97. doi: 10.1016/j.stem.2011.12.018.
17. Wansbury O, Mackay A, Kogata N, Mitsopoulos C, Kendrick H, Davidson K, et al. Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment. Breast Cancer Res. 2011;13(4):R79. doi: 10.1186/bcr2928.
18. Zhang J, Eto K, Honmyou A, Nakao K, Kiyonari H, Abe S. Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis. Development. 2011;138(15):3159-68. doi: 10.1242/dev.062380.
19. Balko JM, Miller TW, Morrison MM, Hutchinson K, Young C, Rinehart C, et al. The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium. Proc Natl Acad Sci U S A. 2012;109(1):221-6. doi: 10.1073/pnas.1115802109.
20. Sims D, Bursteinas B, Gao Q, Jain E, MacKay A, Mitsopoulos C, et al. ROCK: a breast cancer functional genomics resource. Breast Cancer Res Treat. 2010;124(2):567-72. doi: 10.1007/s10549-010-0945-5.
21. Muraoka-Cook RS, Feng SM, Strunk KE, Earp 3rd HS. ErbB4/HER4: role in mammary gland development, differentiation and growth inhibition. J Mammary Gland Biol Neoplasia. 2008;13(2):235-46. doi: 10.1007/s10911-008-9080-x.
22. Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R, et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature. 1995;378(6555):390-4. doi: 10.1038/378390a0.
23. Tidcombe H, Jackson-Fisher A, Mathers K, Stern DF, Gassmann M, Golding JP. Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A. 2003;100(14):8281-6. doi: 10.1073/pnas.1436402100.
24. Long W, Wagner KU, Lloyd KC, Binart N, Shillingford JM, Hennighausen L, et al. Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003;130(21):5257-68. doi: 10.1242/dev.00715.
25. Veikkolainen V, Vaparanta K, Halkilahti K, Iljin K, Sundvall M, Elenius K. Function of ERBB4 is determined by alternative splicing. Cell Cycle. 2011;10(16):2647-57.
26. Elenius K, Corfas G, Paul S, Choi CJ, Rio C, Plowman GD, et al. A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 1997;272(42):26761-8.
27. Elenius K, Choi CJ, Paul S, Santiestevan E, Nishi E, Klagsbrun M. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. Oncogene. 1999;18(16):2607-15. doi: 10.1038/sj.onc.1202612.
28. Muraoka-Cook RS, Sandahl MA, Strunk KE, Miraglia LC, Husted C, Hunter DM, et al. ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol. 2009;29(18):4935-48. doi: 10.1128/MCB.01705-08.
29. Rohrschneider LR, Custodio JM, Anderson TA, Miller CP, Gu H. The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo. Dev Biol. 2005;283(2):503-21. doi: 10.1016/j.ydbio.2005.04.032.