The protective effect of L-carnitine on hepatic ischemia-reperfusion injury in rats

Turkish Journal of Gastroenterology

Volumn 24, Issue 1, 2013, Pages 51-56

  C̈ekin, Ayhan Hilmi ^a   GüR, Gürden ^b   Türkoǧlu, Suna ^c   Aldemir, Derya ^c   Ugur Yilmaz ^c   Gürsoy, Murat ^d   Taşkoparan, Muharrem ^e   Boyacioǧlu, Sedat ^e  

^a Antalya Training and Research Hospital ^*  (Turkey)

^b ANKARA NUMUNE HOSPITAL   (Turkey)

^c Baflkent University   (Turkey)

^d Anadolu Hospital   (Turkey)

^e GÜVEN HOSPITAL   (Turkey)

Author keywords

Antioxidant; Hepatic ischemia reperfusion injury; L carnitine; Lipid peroxidation; Rats

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARNITINE; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; LIVER; LIVER CELL; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; RAT; REPERFUSION INJURY;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARNITINE; DISEASE MODELS, ANIMAL; GLUTATHIONE; LIPID PEROXIDATION; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATIONS; RATS; RATS, WISTAR; REPERFUSION INJURY; VITAMIN B COMPLEX;

EID: 84879681918     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: 10.4318/tjg.2013.0645     Document Type: Article

References (29)

1. Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003;18:891-902.
2. Atila K, Coker A, Sagol O, et al. Protective effects of carnitine in an experimental ischemia-reperfusion injury. Clin Nutr 2002;21:309-13.
3. Yonezawa K, Tolba RH, Wetter A, et al. L-carnitine could not improve hepatic warm ischemia-reperfusion injury despite ameliorated blood flow. J Surg Res 2005;125:16-22.
4. Casillas-Ramiírez A, Mosbah IB, Ramalho F, Roselló-Catafau J, Peralta C. Past and future approaches to ischemiareperfusion lesion associated with liver transplantation. Life Sci 2006;79:1881-94.
5. Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003;284:G15-G26.
6. Serracino-Inglott F, Habib NA, Mathie RT. Hepatic ischemia reperfusion injury. Am J Surgery 2001;181:160-6.
7. Gómez-Amores L, Mate A, Revilla E, Santa-María C, Vázquez CM. Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. Life Sci 2006;78:1945-52.
8. Mansour HH. Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res 2006;54:165-71.
9. Canbaz H, Akca T, Tataroglu C, et al. The effects of exogenous L-carnitine on lipid peroxidation and tissue damage in an experimental warm hepatic ischemia-reperfusion injury model. Cur Ther Res 2007;68:32-46.
10. Arduini A, Holme S, Sweeney JD, et al. Addition of L-carnitine to additive solution-suspended red cells stored at 4 degrees C reduces in vitro hemolysis and improves in vivo viability. Transfusion 1997;37:166-74.
11. Furuno T, Kanno T, Arita K, et al. Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. Biochem Pharmacol 2001;62:1037-46.
12. Izgut-Uysal VN, Agac A, Derin N. Effect of carnitine on stress-induced lipid peroxidation in rat gastric mucosa. J Gastroenterol 2001;36:231-6.
13. Nemoto S, Aoki M, Dehua C, Imai Y. Effects of carnitine on cardiac function after cardioplegic ischemia in neonatal rabbit hearts. Ann Thorac Surg 2001;71:254-9.
14. Mister M, Noris M, Szymczuk J, et al. Propionyl-L-carnitine prevents renal function deterioration due to ischemia/ reperfusion. Kidney Int 2002;61:1064-78.
15. Adembri C, Domenici LL, Formigli L, et al. Ischemia-reperfusion of human skeletal muscle during aortoiliac surgery: effects of acetylcarnitine. Histol Histopathol 1994;9:683-90.
16. Wainwright MS, Mannix MK, Brown J. L-carnitine reduces brain injury after hypoxia-ischemia in newborn rats. Pediatr Res 2003;54:688-95.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
18. Beuge JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52:302-11.
19. Beutler E. Glutathione in red blood cell metabolism. A manual of biochemical methods. New York: Grune & Stratton; 1975;112-4.
20. Dobrzyní ska I, Szachowicz-Petelska B, et al. Effect of L-carnitine on liver cell membranes in ethanol-intoxicated rats. Chem Biol Interact 2010; 188:44-51.
21. Sushamakumari S, Jayadeep A, Kumar JS, Menon VP. Effect of carnitine on malondialdehyde, taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol. Indian J Exp Biol 1989;27:134-7.
22. Yasui F, Matsugo S, Ishibashi M, et al. Effects of chronic acetyl-l-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence accelerated mice. Neurosci Lett 2002;334:177-80.
23. Masubuchi Y, Suda C, Horie T. Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 2005;42:110-6.
24. Kelly GSL. Therapeutic applications of a conditionally essential amino acid. Altern Med Rev 1998;3:345-60
25. Yapar K, Kart A, Karapehlivan M, et al. Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice. Exp Toxicol Pathol 2007;59:121-8.
26. Okatani Y, Wakatsuki A, Enzan H, Miyahara Y. Edaravone protects against ischemia/reperfusion-induced oxidative damage to mitochondria in rat liver. Eur J Pharmacol 2003;465:163-70.
27. Sommer SP, Sommer S, Sinha B, et al. Glutathione preconditioning ameliorates mitochondria dysfunction during warm pulmonary ischemia-reperfusion injury. Eur J Cardiothorac Surg 2012;41:140-8.
28. Sommer SP, Gohrbandt B, Fischer S, et al. Glutathione improves the function of porcine pulmonary grafts stored for twenty-four hours in low-potassium dextran solution. J Thorac Cardiovasc Surg 2005;130:864-9.
29. Li JL, Wang QY, Luan HY, et al. Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha. J Biomed Sci 2012;19:32.