Addition of L-carnitine to additive solution-suspended red cells stored at 4°C reduces in vitro hemolysis and improves in vivo viability

Transfusion

Volumn 37, Issue 2, 1997, Pages 166-174

  Arduini, A ^a   Holme, S ^a   Sweeney, J D ^a   Dottori, S ^a   Sciarroni, A F ^a   Calvani, M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACYLCARNITINE; ADENOSINE TRIPHOSPHATE; CARNITINE; LONG CHAIN FATTY ACID; PRESERVATIVE;

ACYLATION; ADULT; ARTICLE; BLOOD STORAGE; CELL VIABILITY; CONTROLLED STUDY; ERYTHROCYTE LIFESPAN; ERYTHROCYTE MEMBRANE; ERYTHROCYTE METABOLISM; ERYTHROCYTE PRESERVATION; FEMALE; HEMOLYSIS; HUMAN; HUMAN CELL; LIPID METABOLISM; MALE; NORMAL HUMAN;

EID: 0031042003     PISSN: 00411132     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1537-2995.1997.37297203519.x     Document Type: Article

References (52)

1. Moore GL. Red blood cell preservation: a survey of recent research. In: Sohmer PR, Schiffer CA, eds. Blood storage and preservation. A technical workshop. Arlington: American Association of Blood Banks, 1982:9-22.
2. Wolfe LC. The membrane and the lesions of storage in preserved red cells. Transfusion 1985;25:185-203.
3. Heaton WA. Enhancement of cellular elements. In: Wallas CH, McCarthy LJ, eds. New frontiers in blood banking. Arlington: American Association of Blood Banks, 1986:89-125.
4. Heaton WA. Evaluation of posttransfusion recovery and survival of transfused red cells. Transfus Med Rev 1992;6:153-69.
5. Olivieri O, de Franceschi L, de Gironcoli M, et al. Potassium loss and cellular dehydration of stored erythrocytes following incubation in autologous plasma: role of the KCl cotransport system. Vox Sang 1993;65:95-102.
6. Trotter J, Rumsby M. Lipids of the erythrocyte membrane during storage for transfusion. Correlation of lipid changes with the discocyte to spherocyte shape transformation. J Appl Biochem 1981;3:19-31.
7. Greenwalt TJ, Bryan DJ, Dumaswala UJ. Erythrocyte membrane vesiculation and changes in membrane composition during storage in citrate-phosphate-dextrose-adenine-1. Vox Sang 1984;47:261-70.
8. AuBuchon JP, Estep TN, Davey RJ. The effect of the plasticizer di-2-ethylhexyl phthalate on the survival of stored RBCs. Blood 1988;71:448-52.
9. Högman CF, Eriksson L, Ericson Å, Reppucci AJ. Storage of saline-adenine-glucose-mannitol-suspended red cells in a new plastic container: polyvinylchloride plasticized with butyryl-n-trihexyl-citrate. Transfusion 1991;31:26-9.
10. Högman CF, Hedlund K, Sahlestrom Y. Red cell preservation in protein-poor media. III. Protection against in vitro hemolysis. Vox Sang 1981;41:274-81.
11. Carmen R. The selection of plastic materials for blood bags. Transfus Med Rev 1993;7:1-10.
12. Högman CF, Hedlund K, Akerblom O, Venge P. Red blood cell preservation in protein-poor media. I. Leukocyte enzymes as a cause of hemolysis. Transfusion 1978;18:233-41.
13. Bieber LL. Carnitine. Annu Rev Biochem 1988;57:261-83.
14. Snyder JW, Kyle ME, Ferraro TN. L-carnitine delays the killing of cultured hepatocytes by 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine. Arch Biochem Biophys 1990;276:132-8.
15. Volz A, Piper HM, Siegmund B, Schwartz P. Longevity of adult ventricular rat heart muscle cells in serum-free primary culture. J Mol Cell Cardiol 1991;23:161-73.
16. Pastorino JG, Snyder JW, Serroni A, et al. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem 1993;268:13791-8.
17. Semino-Mora MC, Leon-Monzon ME, Dalakas MC. Effect of L-carnitine on the zidovudine-induced destruction of human myotubes. Part I: L-carnitine prevents the myotoxicity of AZT in vitro. Lab Invest 1994;71:102-12.
18. Paulson DJ, Shug AL. Effects of carnitine on the ischemic arrested heart. Basic Res Cardiol 1982;77:460-3.
19. Broderick TL, Quinney HA, Barker CC, Lopashuk GD. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation 1993;87:972-81.
20. Arduini A, Dottori S, Molajoni F, et al. Is the carnitine system part of the heart antioxidant network? In: De Jong JW, Ferrari R, eds. The carnitine system. A new therapeutical approach to cardiovascular medicine. Amsterdam: Kluwer Academic Publisher, 1995:169-81.
21. Cooper MB, Forte CA, Jones DA. Carnitine and acetylcarnitine in red blood cells. Biochim Biophys Acta 1988;959:100-5.
22. Ramsay RR, Mancinelli G, Arduini A. Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity. Biochem J 1991;275(Pt 3):685-8.
23. Kobayashi A, Watanabe H, Fujisawa S, et al. Effects of L-carnitine and palmitoylcarnitine on membrane fluidity of human erythrocytes. Biochim Biophys Acta 1989;986:83-8.
24. Watanabe H, Kobayashi A, Hayashi H, Yamazaki N. Effects of long-chain acyl carnitine on membrane fluidity of human erythrocytes. Biochim Biophys Acta 1989;980:315-8.
25. Arduini A, Rossi M, Mancinelli G, et al. Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability. Life Sci 1990;47:2395-400.
26. Arduini A, Gorbunov N, Arrigoni-Martelli E, et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. Biochim Biophys Acta 1993;1146:229-35.
27. Butterfield DA, Rangachari A. Acetylcarnitine increases membrane cytoskeletal protein-protein interactions. Life Sci 1992;52:297-303.
28. Arduini A, Mancinelli G, Ramsay RR. Palmitoyl-L-carnitine, a metabolic intermediate of the fatty acid incorporation pathway in erythrocyte membrane phospholipids. Biochem Biophys Res Commun 1990;173:212-7.
29. Arduini A, Mancinelli G, Radatti GL, et al. Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes. J Biol Chem 1992;267:12673-81.
30. Ramsay RR, Arduini A. The carnitine acyltransferases and their role in modulating acyl-CoA pools. Arch Biochem Biophys 1993;302:307-14.
31. Arduini A, Tyurin V, Tyurina Y, et al. Carnitine dependent long-chain acyltransferase, an essential component of the membrane's secondary antioxidant response system in human red cells. Life Chem Rep 1994;12:49-54.
32. 51chromium post-transfusion recovery of red cells stored in saline, adenine, glucose, mannitol for 42 days. Vox Sang 1989;57:37-42.
33. Keegan TE, Heaton A, Holme S, et al. Improved post-transfusion quality of density separated AS-3 red cells after extended storage. Br J Haematol 1992;82:114-21.
34. Pace JA, Wannemacher RW Jr, Neufeld HA. Improved radio-chemical assay for carnitine and its derivatives in plasma and tissue extracts. Clin Chem 1978;24:32-5.
35. Rose HG, Hoklander M. Improved procedure for the extraction of lipids from human erythrocytes. J Lipid Res 1965;6:428-31.
36. Bottcher CJ, van Gent GM, Pries C. A rapid and sensitive submicro-phosphorous determination. Anal Chim Acta 1961;24:203-8.
37. Haradin AR, Weed RI, Reed CF. Changes in physical properties of stored erythrocytes. Relationship to survival in vivo. Transfusion 1969;9:229-37.
38. La Celle PL. Alteration of deformability of the erythrocyte membrane in stored blood. Transfusion 1969;9:238-45.
39. Card RT, Mohandas N, Mollison PL. Relationship of post-transfusion viability to deformability of stored red cells. Br J Haematol 1983;53:237-40.
40. Marchesi VT. Stabilizing infrastructure of cell membranes. Annu Rev Cell Biol 1985;1:531-61.
41. Shen BW, Josephs R, Steck TL. Ultrastructure of the intact skeleton of the human erythrocyte membrane. J Cell Biol 1986;102:997-1006.
42. Bennett V. The spectrin-actin junction of erythrocyte membrane skeletons. Biochim Biophys Acta 1989;988:107-21.
43. Wolfe LC, Byrne AM, Lux SE. Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. J Clin Invest 1986;78:1681-6.
44. Fritz IB, Wong K, Burdzy K. Clustering of erythrocytes by fibrinogen is inhibited by carnitine: evidence that sulfhydryl groups on red blood cell membranes are involved in carnitine actions. J Cell Physiol 1991;149:269-76.
45. Shohet SB, Nathan DG, Karnovsky ML. Stages in the incorporation of fatty acids into red blood cells. J Clin Invest 1968;47:1096-108.
46. Dise CA, Goodman DB, Rasmussen H. Definition of the pathway for membrane phospholipid fatty acid turnover in human erythrocytes. J Lipid Res 1980;21:292-300.
47. Lubin BH, Shohet SB, Nathan DG. Changes in fatty acid metabolism after erythrocyte peroxidation: stimulation of a membrane repair process. J Clin Invest 1972;51:338-44.
48. Dise CA, Goodman DB. t-Butyl hydroperoxide alters fatty acid incorporation into erythrocyte membrane phospholipid. Biochim Biophys Acta 1986;859:69-78.
49. Arduini A, Denisova N, Virmani A, et al. Evidence for the involvement of carnitine-dependent long-chain acyltransferases in neuronal triglyceride and phospholipid fatty acid turnover. J Neurochem 1994;62:1530-8.
50. Arduini A, Tyurin V, Tyuruna Y, et al. Acyl-trafficking in membrane phospholipid fatty acid turnover: the transfer of fatty acid from the acyl-L-carnitine pool to membrane phospholipids in intact human erythrocytes. Biochem Biophys Res Commun 1992;187:353-8.
51. McLean LR, Grote C, Silberstein EB, McGill M. Red blood cell membrane microviscosity correlates with posttransfusion survival. Biochem Biophys Res Commun 1988;154:387-91.
52. Wolfe LC. Oxidative injuries to the red cell membrane during conventional blood preservation. Semin Hematol 1989;26:307-12.