Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: Preliminary structure-activity relationship and pharmacophore modeling

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 15, 2013, Pages 4678-4686

  Eterović, Vesna A ^a   Del Valle Rodriguez, Angelie ^a   Pérez, Dinely ^a   Carrasco, Marimée ^a   Khanfar, Mohammad A ^b   El Sayed, Khalid A ^c   Ferchmin, Pedro A ^a  

^a Universidad Central del Caribe School of Medicine   (Puerto Rico)

^b UNIVERSITY OF JORDAN   (Jordan)

^c UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

DFP; Neuroprotection; Neurotoxicity; Organophosphorous insecticide; Pharmacophore modeling; Tobacco cembranoids

Indexed keywords

2,7,11 CEMBRATRIENE 4,6 DIOL DERIVATIVE; CEMBRANOID; DYFLOS; HYDROGEN; NEUROPROTECTIVE AGENT; OXYGEN; SULFUR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN SLICE; CATALYSIS; CHEMICAL MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG SYNTHESIS; HIPPOCAMPUS; HYDROGEN BOND; HYDROPHOBICITY; MALE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

NICOTIANA TABACUM;

EID: 84879677140     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.018     Document Type: Article

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