The pro- and anticoagulant role of blood-borne phagocytes in patients with acute coronary syndrome

Thrombosis and Haemostasis

Volumn 110, Issue 1, 2013, Pages 101-109

  Leers, Math P G ^a   Keuren, Jeffrey F W ^b,c   Frissen, Mick E P W ^a   Huts, Mark ^a   Kragten, Johannes A ^a   Jie, Kon Siong G ^a  

^a Zuyderland Medical Centre   (Netherlands)

^b Zuwe Hofpoort Ziekenhuis   (Netherlands)

^c GROENE HART HOSPITAL   (Netherlands)

Author keywords

Endothelium; Flow cytometry; Microparticles; Phagocytosis; Platelets

Indexed keywords

ANTICOAGULANT AGENT; C REACTIVE PROTEIN; CD14 ANTIGEN; CD16 ANTIGEN; CREATINE KINASE; EPITOPE; PADGEM PROTEIN; PROCOAGULANT; THROMBOPLASTIN; TROPONIN T;

ACUTE CORONARY SYNDROME; ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUTROPHIL; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE CORONARY SYNDROME; ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; APOPTOSIS; BLOOD CELLS; BLOOD COAGULATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PHAGOCYTES; PHAGOCYTOSIS; THROMBOPLASTIN; YOUNG ADULT;

EID: 84879653460     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-09-0643     Document Type: Article

References (32)

1. da Costa Martins PA, van Gils JM, Mol A, et al. Platelet binding to monocytes increases the adhesive properties of monocytes by up-regulating the expression and functionality of beta1 and beta2 integrins. J Leukoc Biol 2006; 79: 499-507.
2. Brambilla M, Camera M, Colnago D, et al. Tissue factor in patients with acute coronary syndromes: expression in platelets, leukocytes, and platelet-leukocyte aggregates. Arterioscler Thromb Vasc Biol 2008; 28: 947-953.
3. Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation 2002; 105: 2130-2132.
4. Jurk K, Kehrel BE. Platelets: physiology and biochemistry. Semin Thromb Hemost 2005; 31: 381-392.
5. Sayed D, Amin NF, Galal GM. Monocyte-platelet aggregates and platelet microparticles in patients with post-hepatitic liver cirrhosis. Thromb Res 2010; 125: e228-233.
6. Harakawa N, Shigeta A, Wato M, et al. P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes. Int Immunol 2007; 19: 321-329.
7. Hrachovinova I, Cambien B, Hafezi-Moghadam A, et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med 2003; 9: 1020-1025.
8. Maugeri N, Rovere-Querini P, Evangelista V, et al. Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and {beta}2 integrindependent cell clearance program. Blood 2009; 113: 5254-5265.
9. Manfredi AA, Rovere-Querini P, Maugeri N. Dangerous connections: neutrophils and the phagocytic clearance of activated platelets. Curr Opin Hematol 2010; 17: 3-8.
10. Maugeri N, Malato S, Femia EA, et al. Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia. Blood 2011; 118: 3359-3366.
11. Wong KL, Yeap WH, Tai JJ, et al. The three human monocyte subsets: implications for health and disease. Immunol Res 2012; 53: 41-57.
12. Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood 2010; 116: e74-80.
13. Ziegler-Heitbrock HW, Fingerle G, Strobel M, et al. The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages. Eur J Immunol 1993; 23: 2053-2058.
14. Zawada AM, Rogacev KS, Rotter B, et al. SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 2011; 118: e50-61.
15. Zawada AM, Rogacev KS, Schirmer SH, et al. Monocyte heterogeneity in human cardiovascular disease. Immunobiology 2012; 217: 1273-1284.
16. Cros J, Cagnard N, Woollard K, et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 2010; 33: 375-386.
17. Hristov M, Schmitz S, Nauwelaers F, et al. A flow cytometric protocol for enumeration of endothelial progenitor cells and monocyte subsets in human blood. J Immunol Methods 2012; 381: 9-13.
18. Hristov M, Schmitz S, Schuhmann C, et al. An optimized flow cytometry protocol for analysis of angiogenic monocytes and endothelial progenitor cells in peripheral blood. Cytometry A 2009; 75: 848-853.
19. Getz GS. Thematic review series: the immune system and atherogenesis. Immune function in atherogenesis. J Lipid Res 2005; 46: 1-10.
20. Ozaki Y, Imanishi T, Taruya A, et al. Circulating CD14+CD16+ Monocyte Subsets as Biomarkers of the Severity of Coronary Artery Disease in Patients With Stable Angina Pectoris. Circ J 2012; Epub ahead of print.
21. Nakamura S, Imamura T, Okamoto K. Tissue factor in neutrophils: yes. J Thromb Haemost 2004; 2: 214-217.
22. Osterud B. Tissue factor in neutrophils: no. J Thromb Haemost 2004; 2: 218-220.
23. Maugeri N, Brambilla M, Camera M, et al. Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation. J Thromb Haemost 2006; 4: 1323-1330.
24. Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008; 8: 802-815.
25. Schlitt A, Heine GH, Blankenberg S, et al. CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost 2004; 92: 419-424.
26. Tsujioka H, Imanishi T, Ikejima H, et al. Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J Am Coll Cardiol 2009; 54: 130-138.
27. Tapp LD, Shantsila E, Wrigley BJ, et al. The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J Thromb Haemost 2012; 10: 1231-1241.
28. Rogacev KS, Cremers B, Zawada AM, et al. CD14++CD16+ Monocytes Independently Predict Cardiovascular Events: A Cohort Study of 951 Patients Referred for Elective Coronary Angiography. J Am Coll Cardiol 2012; 60: 1512-1520.
29. Tacke F, Alvarez D, Kaplan TJ, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 2007; 117: 185-194.
30. Weber C, Belge KU, von Hundelshausen P, et al. Differential chemokine receptor expression and function in human monocyte subpopulations. J Leukoc Biol 2000; 67: 699-704.
31. Ancuta P, Rao R, Moses A, et al. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med 2003; 197: 1701-1707.
32. Heimbeck I, Hofer TP, Eder C, et al. Standardized single-platform assay for human monocyte subpopulations: Lower CD14+CD16++ monocytes in females. Cytometry A 2010; 77: 823-830.