Class specific peptide inhibitors for secretory phospholipases A2

Biochemical and Biophysical Research Communications

Volumn 436, Issue 2, 2013, Pages 349-353

  Mahalka, Ajay K ^a   Kinnunen, Paavo K J ^a  

^a AALTO UNIVERSITY   (Finland)

Author keywords

Oligomerization; Peptide inhibitor; PLA2

Indexed keywords

AMYLOID; BEE VENOM; SECRETORY PHOSPHOLIPASE A2;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; LACRIMAL FLUID; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; BEE VENOMS; BIOCATALYSIS; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHOSPHATIDIC ACIDS; PHOSPHOLIPASES A2, SECRETORY; PROTEIN MULTIMERIZATION; SUBSTRATE SPECIFICITY; TEARS;

APOIDEA;

EID: 84879607371     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.110     Document Type: Article

References (48)

1. Balsinde J., Winstead M.V., Dennis E.A. Phospholipase A(2) regulation of arachidonic acid mobilization. FEBS Lett. 2002, 531:2-6.
2. Balsinde J., Balboa M.A., Insel P.A., et al. Regulation and inhibition of phospholipase A2. Annu. Rev. Pharmacol. Toxicol. 1999, 39:175-189.
3. Six D.A., Dennis E.A. The expanding superfamily of phospholipase A(2) enzymes: classification and characterization. Biochim. Biophys. Acta 2000, 1488:1-19.
4. Dennis E.A., Rhee S.G., Billah M.M., et al. Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991, 5:2068-2077.
5. Scott D.L., White S.P., Otwinowski Z., et al. Interfacial catalysis: the mechanism of phospholipase A2. Science 1990, 250:1541-1546.
6. Dennis E.A. The growing phospholipase A2 superfamily of signal transduction enzymes. Trends Biochem. Sci. 1997, 22:1-2.
7. Dennis E.A. Diversity of group types, regulation, and function of phospholipase A2. J. Biol. Chem. 1994, 269:13057-13060.
8. Farooqui A.A., Ong W.Y., Horrocks L.A. Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders. Pharmacol. Rev. 2006, 58:591-620.
9. Gattaz W.F., Kollisch M., Thuren T., et al. Increased plasma phospholipase-A2 activity in schizophrenic patients: reduction after neuroleptic therapy. Biol. Psychiatry 1987, 22:421-426.
10. Corson M.A. Phospholipase A2 inhibitors in atherosclerosis: the race is on. Lancet 2009, 373:608-610.
11. Dennis E.A., Cao J., Hsu Y.H., et al. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem. Rev. 2011, 111:6130-6185.
12. Moriyama T., Urade R., Kito M. Purification and characterization of diacylglycerol lipase from human platelets. J. Biochem. 1999, 125:1077-1085.
13. Balsinde J., Dennis E.A. Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J. Biol. Chem. 1996, 271:31937-31941.
14. Mustonen P., Lehtonen J.Y., Kinnunen P.K.J. Binding of quinacrine to acidic phospholipids and pancreatic phospholipase A2. Effects on the catalytic activity of the enzyme. Biochemistry 1998, 37:12051-12057.
15. Mounier C., Vargaftig B.B., Franken P.A., et al. Platelet secretory phospholipase A2 fails to induce rabbit platelet activation and to release arachidonic acid in contrast with venom phospholipases A2. Biochim. Biophys. Acta 1994, 1214:88-96.
16. Takayama K., Hara S., Kudo I., et al. Detection of 14-kDa group II phospholipase A2 in human seminal plasma. Biochem. Biophys. Res. Commun. 1991, 178:1505-1511.
17. Nevalainen T.J., Aho H.J., Peuravuori H. Secretion of group 2 phospholipase A2 by lacrimal glands. Invest. Ophthalmol. Vis. Sci. 1994, 35:417-421.
18. Menschikowski M., Hagelgans A., Siegert G. Secretory phospholipase A2 of group IIA: is it an offensive or a defensive player during atherosclerosis and other inflammatory diseases?. Prostaglandins Other Lipid Mediat. 2006, 79:1-33.
19. Code C., Domanov Y., Jutila A., et al. Amyloid-type fiber formation in control of enzyme action: interfacial activation of phospholipase A2. Biophys. J. 2008, 95:215-224.
20. Mahalka A.K., Code C., Rezaijahromi B., et al. Activation of phospholipase A2 by Hsp70 in vitro. Biochim. Biophys. Acta 1808, 2011:2569-2572.
21. Zhao H., Kinnunen P.K.J. Modulation of the activity of secretory phospholipase A2 by antimicrobial peptides. Antimicrob. Agents Chemother. 2003, 47:965-971.
22. Code C., Domanov Y.A., Killian J.A., et al. Activation of phospholipase A2 by temporin B: formation of antimicrobial peptide-enzyme amyloid-type cofibrils. Biochim. Biophys. Acta 2009, 1788:1064-1072.
23. Code C., Mahalka A.K., Bry K., et al. Activation of phospholipase A2 by 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine in vitro. Biochim. Biophys. Acta 2010, 1798:1593-1600.
24. Larsen T.A., Olson A.J., Goodsell D.S. Morphology of protein-protein interfaces. Structure 1998, 6:421-427.
25. Boden M., Yuan Z., Bailey T.L. Prediction of protein continuum secondary structure with probabilistic models based on NMR solved structures. BMC Bioinformatics 2006, 7:68.
26. Conchillo-Sole O., de Groot N.S., Aviles F.X., et al. AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics 2007, 8:65.
27. Fernandez-Escamilla A.M., Rousseau F., Schymkowitz J., et al. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat. Biotechnol. 2004, 22:1302-1306.
28. Trovato A., Seno F., Tosatto S.C. The PASTA server for protein aggregation prediction. Protein Eng. Des. Sel. 2007, 20:521-523.
29. Thuren T., Virtanen J.A., Somerharju P.J., et al. Phospholipase A2 assay using an intramolecularly quenched pyrene-labeled phospholipid analog as a substrate. Anal. Biochem. 1988, 170:248-255.
30. Thuren T., Virtanen J.A., Kinnunen P.K.J. Polyamine-phospholipid interaction probed by the accessibility of the phospholipid sn-2 ester bond to the action of phospholipase A2. J. Membr. Biol. 1986, 92:1-7.
31. Thuren T., Virtanen J.A., Lalla M., et al. Fluorometric assay for phospholipase A2 in serum. Clin. Chem. 1985, 31:714-717.
32. Mahalka A.K., Kinnunen P.K.J. Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: lessons from temporins B and L. Biochim. Biophys. Acta 2009, 1788:1600-1609.
33. Sanchez S.A., Bagatolli L.A., Gratton E., et al. A two-photon view of an enzyme at work: crotalus atrox venom PLA2 interaction with single-lipid and mixed-lipid giant unilamellar vesicles. Biophys. J. 2002, 82:2232-2243.
34. Zhou L., Zhao S.Z., Koh S.K., et al. In-depth analysis of the human tear proteome. J. Proteomics 2012, 75:3877-3885.
35. Lopez de la Paz M., Serrano L. Sequence determinants of amyloid fibril formation. Proc. Natl. Acad. Sci. USA 2004, 101:87-92.
36. Calamai M., Taddei N., Stefani M., et al. Relative influence of hydrophobicity and net charge in the aggregation of two homologous proteins. Biochemistry 2003, 42:15078-15083.
37. Nicolas J.P., Lin Y., Lambeau G., et al. Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity. J. Biol. Chem. 1997, 272:7173-7181.
38. Kini R.M., Iwanaga S. Structure-function relationships of phospholipases. I: prediction of presynaptic neurotoxicity. Toxicon 1986, 24:527-541.
39. Lehtonen J.Y., Holopainen J.M., Kinnunen P.K.J. Activation of phospholipase A2 by amyloid beta-peptides in vitro. Biochemistry 1996, 35:9407-9414.
40. Pochet S., Tandel S., Querriere S., et al. Modulation by LL-37 of the responses of salivary glands to purinergic agonists. Mol. Pharmacol. 2006, 69:2037-2046.
41. Signor G., Mammi S., Peggion E., et al. Interaction of bombolitin III with phospholipid monolayers and liposomes and effect on the activity of phospholipase A2. Biochemistry 1994, 33:6659-6670.
42. Koumanov K., Momchilova A., Wolf C. Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2. Cell Biol. Int. 2003, 27:871-877.
43. Hazlett T.L., Deems R.A., Dennis E.A. Activation, aggregation, inhibition and the mechanism of phospholipase A2. Adv. Exp. Med. Biol. 1990, 279:49-64.
44. Hille J.D., Egmond M.R., Dijkman R., et al. Aggregation of porcine pancreatic phospholipase A2 and its zymogen induced by submicellar concentrations of negatively charged detergents. Biochemistry 1983, 22:5347-5353.
45. Grainger D.W., Reichert A., Ringsdorf H., et al. Hydrolytic action of phospholipase A2 in monolayers in the phase transition region: direct observation of enzyme domain formation using fluorescence microscopy. Biochim. Biophys. Acta 1990, 1023:365-379.
46. Bell J.D., Biltonen R.L. The temporal sequence of events in the activation of phospholipase A2 by lipid vesicles. studies with the monomeric enzyme from agkistrodon piscivorus piscivorus. J. Biol. Chem. 1989, 264:12194-12200.
47. Hayouka Z., Rosenbluh J., Levin A., et al. Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium. Proc. Natl. Acad. Sci. USA 2007, 104:8316-8321.
48. Hayouka Z., Rosenbluh J., Levin A., et al. Peptides derived from HIV-1 rev inhibit HIV-1 integrase in a shiftide mechanism. Biopolymers 2008, 90:481-487.