Preoperative chemoradiotherapy improves local recurrence free survival in locally advanced rectal cancer

Journal of B.U.ON.

Volumn 18, Issue 2, 2013, Pages 385-390

  Tural, Deniz ^a   Ozturk, M ^a   Selcukbiricik, F ^a   Yildiz, O ^a   Elicin, O ^a   Turna, H ^a   Guney, S ^a   Ozguroglu, M ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Locally advanced; Postoperative chemoradiotherapy; Preoperative chemoradiotherapy; Rectal cancer; Treatment outcome

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ANASTOMOSIS LEAKAGE; ANASTOMOSIS STENOSIS; ARTICLE; BLOOD CELL COUNT; BLOOD TOXICITY; CANCER RECURRENCE; CANCER STAGING; CHEMORADIOTHERAPY; COLONOSCOPY; CONTROLLED STUDY; DERMATITIS; DIARRHEA; FEMALE; FISTULA; HERNIA; HISTOPATHOLOGY; HUMAN; LOCAL RECURRENCE FREE SURVIVAL; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NAUSEA AND VOMITING; OVERALL SURVIVAL; PELVIS ABSCESS; PERINEURAL INVASION; POSTOPERATIVE CARE; PREOPERATIVE CHEMORADIOTHERAPY; PREOPERATIVE TREATMENT; RADIATION DOSE; RECTUM CANCER; RETROSPECTIVE STUDY;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY; CHI-SQUARE DISTRIBUTION; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HUMANS; KAPLAN-MEIER ESTIMATE; LEUCOVORIN; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RADIATION DOSAGE; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84879596070     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Sauer R, Becker H, Hohenberger W. Preoperative versus Postoperative CRT for Rectal Cancer. The German Rectal Cancer Study Group. N Engl J Med 2004;351:1731-1740.
2. Guillem JG, Díaz-Gonzalez JA, Minskyc BD. T3N0 rectal cancer: potential overtreatment with preoperative CRT is warranted. J Clin Oncol 2008;26:368-373. (Pubitemid 351171686)
3. Cawthorn Sj, Parums DV, Gibbs NM. Extent of mesorectal spread and involvement of lateral resection as prognostic factors after surgery for rectal cancer. Lancet 1990;335:1055-1059. (Pubitemid 20148648)
4. Havenga K, Enker WE, Norstein J. Improved survival and local control after total mesorectal excision or D3 lymphadenectomy in the treatment of primary rectal cancer:An international analysis of 1411 patients. Eur J Surg Oncol 1999;24:368-374. (Pubitemid 29364222)
5. Kapiteijn E, Marijnen CAM, Nagtegaal ID. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638-646.
6. Birgisson H, Pahlman L, Gunnarsson U. Adverse effects of preoperative radiation therapy for rectal cancer: Long-term follow-up of the Swedish Rectal Cancer Trial. J Clin Oncol 2005;23:8697-8705. (Pubitemid 46211513)
7. Peeters KC, Marijnen CA, Nagtegaal ID.The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007;246:693-701. (Pubitemid 350035641)
8. Sebag-Montefiore D, Stephens RJ, Steele R. Preoperative radiotherapy versus selective postoperative CRT in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 2009;373:811-820.
9. Ceelen WP, Van Nieuwenhove Y, Fierens K. Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev 2009: CD006041.
10. Bosset JF, Calais G, Mineur L. Enhanced tumoricidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results - EORTC 22921. J Clin Oncol 2005;23:5620-5627.
11. Bosset JF, Collette L, Calais G. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:1114-1123. (Pubitemid 44394918)
12. Gérard JP, Conroy T, Bonnetain F. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006; 24:4620-4625. (Pubitemid 46630960)
13. Roh MS, Colangelo LH, O'Connell MJ. Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol 2009;27:5124-5130.
14. Kao PS, Chang SC, Wang LW. The impact of preoperative chemoradiotherapy on advanced low rectal cancer. J Surg Oncol 2010;102:771-777.
15. Enker WE, Merchant N, Cohen AM. Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service. Ann Surg 1999;230:544-552.
16. Ulrich A, Weitz J, Slodczyk M. Neoadjuvant treatment does not influence perioperative outcome in rectal cancer surgery. Int J Radiat Oncol Biol Phys 2009;75:129-136.
17. protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol 2002; 20:1996-2004.