Guaifenesin derivatives promote neurite outgrowth and protect diabetic mice from neuropathy

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 5071-5078

  Hadimani, Mallinath B ^c   Purohit, Meena K ^a,b   Vanampally, Chandrashaker ^c   Van Der Ploeg, Randy ^e   Arballo, Victor ^d   Morrow, Dwane ^e   Frizzi, Katie E ^d   Calcutt, Nigel A ^d   Fernyhough, Paul ^e   Kotra, Lakshmi P ^a,c,f  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^c UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MANITOBA   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL GROUP; GUAIFENESIN; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; ENANTIOMER; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MEMBRANE PERMEABILITY; MICROWAVE IRRADIATION; MOTOR NERVE CONDUCTION; MOUSE; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; RAT; SENSORY NERVE CELL; SPINAL GANGLION; STREPTOZOCIN DIABETES; STRUCTURE ACTIVITY RELATION; VELOCITY;

ANIMALS; DIABETIC NEUROPATHIES; FEMALE; GUAIFENESIN; HUMANS; MALE; MICE; MICROSOMES, LIVER; NEURITES; PERMEABILITY; RATS; STEREOISOMERISM;

EID: 84879590428     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400401y     Document Type: Article

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