Severe bacterial infection: Increased mortality in elderly women with low body weight taking drugs prolonging the QTc interval;Schwere bakterielle Infektionen: Erhöhte Mortalität bei älteren Frauen mit niedrigem Körpergewicht unter QTc-Intervall-verlängernder Medikation

Medizinische Klinik - Intensivmedizin und Notfallmedizin

Volumn 107, Issue 4, 2012, Pages 275-284

  Suefke, S ^a   Djonlagic H ^a   Kibbel, T ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Age; Bacterial infection; Body weight; Gender; QT interval prolonging drugs

Indexed keywords

MACROLIDE; QUINOLONE DERIVATIVE;

ADULT; AGE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BODY WEIGHT; COMPARATIVE STUDY; CRITICALLY ILL PATIENT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; QT PROLONGATION;

EID: 84879587820     PISSN: 21936218     EISSN: 21936226     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Haverkamp W, Breithardt G, Camm AJ et al (2000) The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications report on a policy conference of the European Society of Cardiology. Cardiovasc Res 47: 219-233.
2. De Bruin ML, Langendijk PN, Koopmans RP et al (2007) In-hospital cardiac arrest is associated with use of non-antiarrhythmic QTc-prolonging drugs. Br J Clin Pharmacol 63: 216-223.
3. Sommargren CE, Drew BJ (2007) Preventing torsades de pointes by careful cardiac monitoring in hospital settings. AACN Adv Crit Care 18: 285-293.
4. Beauregard LA (2002) Incidence and management of arrhythmias in women. J Gend Specif Med 5: 38-48.
5. Wolbrette D, Naccarelli G, Curtis A et al (2002) Gender differences in arrhythmias. Clin Cardiol 25: 49-56.
6. Makkar RR, Fromm BS, Steinman RT et al (1993) Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 270: 2590-2597.
7. Viskin S (1999) Long QT syndromes and torsade de pointes. Lancet 354: 1625-1633.
8. Drici MD, Knollmann BC, Wang WX, Woosley RL (1998) Cardiac actions of erythromycin - Influence of female sex. JAMA 280: 1774-1776.
9. Reardon M, Malik M (1996) QT interval change with age in an overtly healthy older population. Clin Cardiol 19: 949-952.
10. Heist EK, Ruskin JN (2010) Drug-induced arrhythmia. Circulation 122: 1426-1435.
11. Rubinstein E, Camm J (2002) Cardiotoxicity of fluoroquinolones. J Antimicrob Chemother 49: 593-596.
12. Jochmann N, Stangl K, Garbe E et al (2005) Female-specific aspects in the pharmacotherapy of chronic cardiovascular diseases. Eur Heart J 26: 1585-1595.
13. Overholser BR, Kays MB, Lagvankar S et al (2005) Pharmacokinetics of intravenously administered levofloxacin in men and women. Pharmacotherapy 25: 1310-1318.
14. Rieck W, Mühlberg W, Matzke M, Platt D (2002) Forschungsbericht der Medizinischen Fakultät der Friedrich-Alexander-Universität Erlangen-Nürnberg 1999-2001, S 167-175.
15. Rebuck JA, Fish DN, Abraham E (2002) Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy 22: 1216-1225.
16. Falagas ME, Karageorgopaulos D (2010) Adjustment of antimicrobial agents for bodyweight in adults. Lancet 375: 248-251.
17. Rowan K (1998) Are scoring systems adequate indicators for quality and performance of the ICU? Anasthesiol Intensivmed Notfallmed Schmerzther 33: 52-55.
18. Lemeshow S, Teres D, Klar J et al (1993) Mortality Probability Models (MPM II) based on an international cohort of Intensive Care Unit patients. JAMA 270: 2478-2486.
19. Bodmann KF (2005) Current guidelines for the treatment of severe pneumonia and sepsis. Chemotherapy 51: 227-233.
20. Kepa L, Oczko-Grzesik B (2001) Usefulness of plasma C-reactive protein (CRP) estimation in patients with bacterial sepsis. Przegl Epidemiol 55(Suppl 3): 63-67.
21. Schmit X, Vincent JL (2008) The time course of blood C-reactive protein concentrations in relation to the response to initial antimicrobial therapy in patients with sepsis. Infection 36: 213-219.
22. Jayasinghe R, Kovoor P (2002) Drugs and the QTc interval. Aust Prescr 25: 63-65.
23. Herrath D von, Ludwig WD, Oelkers W et al (2004) Medikamenten-induzierte abnorme QT-Zeit-Verlängerung und Torsade de Pointes. Arzneimittelbrief 38: 49-51.
24. Knorr JP, Moshfeghi M, Sokoloski MC (2008) Ciprofloxacin-induced Q-T interval prolongation. Am J Health Syst Pharm 65: 547-551.
25. Horowitz LN (1994) Polymorphic ventricular tachycardia, including torsades de pointes. In: Kastor JA (Hrsg) Arrhythmias, Chapter 16. WB Saunders, Philadelphia, S 376-94.
26. Woywodt A, Grommas U, Buth W, Rafflenbeul W (2000) QT prolongation due to roxythromycin. Postgrad Med J 76: 651-654.
27. Viskin S, Barron HV, Olgin J et al (1997) The treatment of atrial fibrillation: pharmacologic and non-pharmacologic strategies. Curr Probl Cardiol 22: 37-108.
28. Herbertz HC (2002) Informationen des Bundeswahlleiters. In: Hahlen J, Statistisches Bundesamt Wiesbaden (Hrsg) Wirtschaft und Statistik. Metzler-Poeschel, Stuttgart, S 83.
29. Ramaekers D, Ector H, Aubert AE et al (1998) Heart rate variability and heart rate in healthy volunteers - Is the female autonomic nervous system cardioprotective? Eur Heart J 19: 1334-1341.
30. Rello J, Ollendorf DA, Oster G et al (2002) Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 122: 2115-2121.
31. Dupont H, Mentec H, Sollet JP, Bleichner G (2001) Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 27: 355-362.
32. Berkowitz DM, Martin GS (2007) Sepsis and sex - Can we look beyond our hormones? Chest 132: 1725-1727.
33. Borovikova LV, Ivanova S, Zhang M et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405: 458-462.
34. Huikuri HV, Pikkujamsa SM, Airaksinen KE et al (1996) Sex-related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation 94: 122-125.
35. Adrie C, Azouley E, Francais A et al (2007) Influence of gender on the outcome of severe sepsis: a reappraisal. Chest 132: 1786-1793.
36. Leibovici L, Paul M, Weinberger M et al (2001) Excess mortality in women with hospital-acquired bloodstream infection. Am J Med 111: 120-125.
37. Erikoǧlu M, Şahin M, Özer Ş, Avanduk MC (2005) Effect of gender on the severity of sepsis. Surg Today 35: 467-472.
38. Bernhardt JA, d'Acampora AJ, Tramonte R, Serafim JDM (2007) Effect of post-natal castration on sepsis mortality in rats. Acta Cir Bras 22: 22-29.
39. Bruunsgaard H, Pedersen AN, Schroll M et al (1999) Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans. Clin Exp Immunol 118: 235-241.
40. Juneja D, Singh O, Nasa P, Dang R (2011) Comparison of newer scoring systems with the conventional scoring systems in general intensive care population. Minerva Anesthesiol 78: 194-200.
41. Sharma ND, Rosman HS, Padhi ID, Tisdale JE (1998) Torsades de pointes associated with intravenous haloperidol in critically ill patients. Am J Cardiol 81: 238-240.
42. Vieweg WV, Wood MA, Fernandez A et al (2009) Proarrhythmic risk with antipsychtic and antidepressant drugs: implications in the elderly. Drugs Aging 26: 997-1012.
43. Viskin S, Antzelevitch C (2005) The cardiologists' worst nightmare: Sudden death from "benign" ventricular arrhythmias. J Am Coll Cardiol 46: 1295-1297.
44. Owens RC Jr, Nolin T (2006) Antimicrobial-associated QT interval prolongation: Pointes of interest. Clin Infect Dis 43: 1603-1611.
45. Birati EY, Belhassen B, Bardai A et al (2011) The site of origin of torsade de pointes. Heart 97: 1650-1654.
46. Meester A de, Deltenre P, Chaudron JM (1995) Major prolongation of the QT interval observed in the course of massive pulmonary embolism. Acta Clin Belg 50: 301-304.
47. Agarwal SK, Heiss G, Rautaharju PM et al (2010) Premature ventricular complexes and the risk of incident stroke: the Atherosclerosis Risk In Communities (ARIC) Study. Stroke 41: 588-593.
48. Meierhenrich R, Steinhilber E, Eggermann C et al (2010) Incidence and prognostic impact of new-onset atrial fibrillation in patients with septic shock: a prospective observational study. Crit Care 14: R108.
49. Akinnusi ME, Pineda LA, El Solh AA (2008) Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med 36: 151-158.
50. Oliveros H, Villamor E (2008) Obesity and mortality in critically ill adults: a systematic review and meta-analysis. Obesity 16: 515-521.
51. Kannankeril PJ, Norris KJ, Carter S, Roden DM (2011) Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers. Heart Rhythm 8: 1530-1534.
52. Yap YG, Camm AJ (2003) Drug induced QT prolongation and torsades de pointes. Heart 89: 1363-1372.
53. Woodhead M, Gialdroni Grassi G, Huchon GJ et al (1996) Use of investigations in lower respiratory tract infection in the community: a European survey. Eur Respir J 9: 1596-1600.
54. Harbarth S, Albrich W, Brun-Buisson C (2002) Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: a Sociocultural Perspective. Emerg Infect Dis 8: 1460-1467.
55. Bercault N, Boulain T, Kuteifan K et al (2004) Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study. Crit Care Med 32: 998-1003.
56. Goulenok C, Monchi M, Chiche JD et al (2004) Influence of overweight on ICU mortality. A prospective study. Chest 125: 1441-1445.