메뉴 건너뛰기




Volumn 288, Issue 26, 2013, Pages 18885-18893

Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; COMPLEX ASSEMBLY; FUSION INHIBITORS; INHIBITORY FUNCTION; MEMBRANE FUSION; REGULATORY FACTORS; REGULATORY MECHANISM; SOLUBLE N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT PROTEIN RECEPTOR;

EID: 84879586340     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.465450     Document Type: Article
Times cited : (20)

References (66)
  • 1
    • 58849092285 scopus 로고    scopus 로고
    • Membrane fusion: Grappling with SNARE and SM proteins
    • Südhof, T. C., and Rothman, J. E. (2009) Membrane fusion: grappling with SNARE and SM proteins. Science 323, 474-477
    • (2009) Science , vol.323 , pp. 474-477
    • Südhof, T.C.1    Rothman, J.E.2
  • 2
    • 2142759571 scopus 로고    scopus 로고
    • 23 Genes, 23 years later
    • Schekman, R., and Novick, P. (2004) 23 genes, 23 years later. Cell 116, S13-15
    • (2004) Cell , vol.116
    • Schekman, R.1    Novick, P.2
  • 3
    • 0024512585 scopus 로고
    • Identification of a novel gene encoding an insulin-responsive glucose transporter protein
    • Birnbaum, M. J. (1989) Identification of a novel gene encoding an insulin-responsive glucose transporter protein. Cell 57, 305-315
    • (1989) Cell , vol.57 , pp. 305-315
    • Birnbaum, M.J.1
  • 4
    • 0024592462 scopus 로고
    • Molecular cloning and characterization of an insulin-regulatable glucose transporter
    • DOI 10.1038/338083a0
    • James, D. E., Strube, M., and Mueckler, M. (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338, 83-87 (Pubitemid 19076789)
    • (1989) Nature , vol.338 , Issue.6210 , pp. 83-87
    • James, D.E.1    Strube, M.2    Mueckler, M.3
  • 6
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 Glucose Transporter
    • DOI 10.1016/j.cmet.2007.03.006, PII S1550413107000678
    • Huang, S., and Czech, M. P. (2007) The GLUT4 glucose transporter. Cell Metab. 5, 237-252 (Pubitemid 46477860)
    • (2007) Cell Metabolism , vol.5 , Issue.4 , pp. 237-252
    • Huang, S.1    Czech, M.P.2
  • 7
    • 77749306186 scopus 로고    scopus 로고
    • Exocytosis mechanisms underlying insulin release and glucose uptake: Conserved roles for Munc18c and syntaxin 4
    • Jewell, J. L., Oh, E., and Thurmond, D. C. (2010) Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R517-531
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.298
    • Jewell, J.L.1    Oh, E.2    Thurmond, D.C.3
  • 8
    • 0036270751 scopus 로고    scopus 로고
    • Regulated transport of the glucose transporter GLUT4
    • DOI 10.1038/nrm782
    • Bryant, N. J., Govers, R., and James, D. E. (2002) Regulated transport of the glucose transporter GLUT4. Nat. Rev. Mol. Cell Biol. 3, 267-277 (Pubitemid 34619262)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.4 , pp. 267-277
    • Bryant, N.J.1    Govers, R.2    James, D.E.3
  • 9
    • 33645997012 scopus 로고    scopus 로고
    • Bridging the GAP between insulin signaling and GLUT4 translocation
    • Watson, R. T., and Pessin, J. E. (2006) Bridging the GAP between insulin signaling and GLUT4 translocation. Trends Biochem. Sci. 31, 215-222
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 215-222
    • Watson, R.T.1    Pessin, J.E.2
  • 11
    • 54249154367 scopus 로고    scopus 로고
    • Molecular mechanisms controlling GLUT4 intracellular retention
    • Blot, V., and McGraw, T. E. (2008) Molecular mechanisms controlling GLUT4 intracellular retention. Mol. Biol. Cell 19, 3477-3487
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3477-3487
    • Blot, V.1    McGraw, T.E.2
  • 12
    • 0028142398 scopus 로고
    • Insulin signalling and the stimulation of glucose transport
    • Lavan, B. E., and Lienhard, G. E. (1994) Insulin signalling and the stimulation of glucose transport. Biochem. Soc. Trans. 22, 676-680 (Pubitemid 24272788)
    • (1994) Biochemical Society Transactions , vol.22 , Issue.3 , pp. 676-680
    • Lavan, B.E.1    Lienhard, G.E.2
  • 13
  • 15
    • 84870232182 scopus 로고    scopus 로고
    • The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices: Guilty as charged?
    • Rizo, J., and Südhof, T. C. (2012) The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices: guilty as charged? Annu. Rev. Cell Dev. Biol. 28, 279-308
    • (2012) Annu. Rev. Cell Dev. Biol. , vol.28 , pp. 279-308
    • Rizo, J.1    Südhof, T.C.2
  • 16
    • 84867295592 scopus 로고    scopus 로고
    • Molecular machines governing exocytosis of synaptic vesicles
    • Jahn, R., and Fasshauer, D. (2012) Molecular machines governing exocytosis of synaptic vesicles. Nature 490, 201-207
    • (2012) Nature , vol.490 , pp. 201-207
    • Jahn, R.1    Fasshauer, D.2
  • 18
    • 3543096759 scopus 로고    scopus 로고
    • Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
    • DOI 10.1038/26412
    • Sutton, R. B., Fasshauer, D., Jahn, R., and Brunger, A. T. (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature 395, 347-353 (Pubitemid 28450677)
    • (1998) Nature , vol.395 , Issue.6700 , pp. 347-353
    • Sutton, R.B.1    Fasshauer, D.2    Jahn, R.3    Brunger, A.T.4
  • 19
    • 65649153795 scopus 로고    scopus 로고
    • Capture and release of partially zipped trans-SNARE complexes on intact organelles
    • Schwartz, M. L., and Merz, A. J. (2009) Capture and release of partially zipped trans-SNARE complexes on intact organelles. J. Cell Biol. 185, 535-549
    • (2009) J. Cell Biol. , vol.185 , pp. 535-549
    • Schwartz, M.L.1    Merz, A.J.2
  • 20
    • 33947657322 scopus 로고    scopus 로고
    • Membrane Trafficking: Three Steps to Fusion
    • DOI 10.1016/j.cub.2007.02.006, PII S0960982207009451
    • Burgoyne, R. D., and Morgan, A. (2007) Membrane trafficking: three steps to fusion. Curr. Biol. 17, R255-258 (Pubitemid 46497788)
    • (2007) Current Biology , vol.17 , Issue.7
    • Burgoyne, R.D.1    Morgan, A.2
  • 21
    • 79960303122 scopus 로고    scopus 로고
    • HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites
    • Krämer, L., and Ungermann, C. (2011) HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites. Mol. Biol. Cell 22, 2601-2611
    • (2011) Mol. Biol. Cell , vol.22 , pp. 2601-2611
    • Krämer, L.1    Ungermann, C.2
  • 22
    • 45849152550 scopus 로고    scopus 로고
    • Mechanisms of membrane fusion: Disparate players and common principles
    • DOI 10.1038/nrm2417, PII NRM2417
    • Martens, S., and McMahon, H. T. (2008) Mechanisms of membrane fusion: disparate players and common principles. Nat. Rev. Mol. Cell Biol. 9, 543-556 (Pubitemid 351881838)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.7 , pp. 543-556
    • Martens, S.1    McMahon, H.T.2
  • 25
    • 33746915109 scopus 로고    scopus 로고
    • N- to C-terminal SNARE complex assembly promotes rapid membrane fusion
    • DOI 10.1126/science.1129486
    • Pobbati, A. V., Stein, A., and Fasshauer, D. (2006) N- to C-terminal SNARE complex assembly promotes rapid membrane fusion. Science 313, 673-676 (Pubitemid 44201146)
    • (2006) Science , vol.313 , Issue.5787 , pp. 673-676
    • Pobbati, A.V.1    Stein, A.2    Fasshauer, D.3
  • 27
    • 84866132236 scopus 로고    scopus 로고
    • Single reconstituted neuronal SNARE complexes zipper in three distinct stages
    • Gao, Y., Zorman, S., Gundersen, G., Xi, Z., Ma, L., Sirinakis, G., Rothman, J. E., and Zhang, Y. (2012) Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science 337, 1340-1343
    • (2012) Science , vol.337 , pp. 1340-1343
    • Gao, Y.1    Zorman, S.2    Gundersen, G.3    Xi, Z.4    Ma, L.5    Sirinakis, G.6    Rothman, J.E.7    Zhang, Y.8
  • 28
    • 58149333495 scopus 로고    scopus 로고
    • Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro
    • Brandie, F. M., Aran, V., Verma, A., McNew, J. A., Bryant, N. J., and Gould, G. W. (2008) Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro. PLoS One 3, e4074
    • (2008) PLoS One , vol.3
    • Brandie, F.M.1    Aran, V.2    Verma, A.3    McNew, J.A.4    Bryant, N.J.5    Gould, G.W.6
  • 29
    • 34447543968 scopus 로고    scopus 로고
    • Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking
    • DOI 10.1074/jbc.M610818200
    • D'Andrea-Merrins, M., Chang, L., Lam, A. D., Ernst, S. A., and Stuenkel, E. L. (2007) Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J. Biol. Chem. 282, 16553-16566 (Pubitemid 47100374)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.22 , pp. 16553-16566
    • D'Andrea-Merrins, M.1    Chang, L.2    Lam, A.D.3    Ernst, S.A.4    Stuenkel, E.L.5
  • 31
  • 33
  • 34
    • 33845987734 scopus 로고    scopus 로고
    • Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
    • DOI 10.1016/j.cell.2006.12.016, PII S0092867406016102
    • Shen, J., Tareste, D. C., Paumet, F., Rothman, J. E., and Melia, T. J. (2007) Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 128, 183-195 (Pubitemid 46048894)
    • (2007) Cell , vol.128 , Issue.1 , pp. 183-195
    • Shen, J.1    Tareste, D.C.2    Paumet, F.3    Rothman, J.E.4    Melia, T.J.5
  • 35
    • 0242286216 scopus 로고    scopus 로고
    • Liposome Fusion Assay to Monitor Intracellular Membrane Fusion Machines
    • DOI 10.1016/S0076-6879(03)72016-3
    • Scott, B. L., Van Komen, J. S., Liu, S., Weber, T., Melia, T. J., and McNew, J. A. (2003) Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol. 372, 274-300 (Pubitemid 37337813)
    • (2003) Methods in Enzymology , vol.372 , pp. 274-300
    • Scott, B.L.1    Van Komen, J.S.2    Liu, S.3    Weber, T.4    Mella, T.J.5    McNew, J.A.6
  • 36
    • 77954715092 scopus 로고    scopus 로고
    • SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion
    • Shen, J., Rathore, S. S., Khandan, L., and Rothman, J. E. (2010) SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J. Cell Biol. 190, 55-63
    • (2010) J. Cell Biol. , vol.190 , pp. 55-63
    • Shen, J.1    Rathore, S.S.2    Khandan, L.3    Rothman, J.E.4
  • 37
    • 79960301464 scopus 로고    scopus 로고
    • Topological arrangement of the intracellular membrane fusion machinery
    • Rathore, S. S., Ghosh, N., Ouyang, Y., and Shen, J. (2011) Topological arrangement of the intracellular membrane fusion machinery. Mol. Biol. Cell 22, 2612-2619
    • (2011) Mol. Biol. Cell , vol.22 , pp. 2612-2619
    • Rathore, S.S.1    Ghosh, N.2    Ouyang, Y.3    Shen, J.4
  • 38
    • 84876565914 scopus 로고    scopus 로고
    • Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner
    • Yu, H., Rathore, S. S., Davis, E. M., Ouyang, Y., and Shen, J. (2013) Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol. Biol. Cell 24, 1176-1184
    • (2013) Mol. Biol. Cell , vol.24 , pp. 1176-1184
    • Yu, H.1    Rathore, S.S.2    Davis, E.M.3    Ouyang, Y.4    Shen, J.5
  • 39
  • 41
  • 42
    • 78651078463 scopus 로고    scopus 로고
    • Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex
    • Rathore, S. S., Bend, E. G., Yu, H., Hammarlund, M., Jorgensen, E. M., and Shen, J. (2010) Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc. Natl. Acad. Sci. U.S.A. 107, 22399-22406
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 22399-22406
    • Rathore, S.S.1    Bend, E.G.2    Yu, H.3    Hammarlund, M.4    Jorgensen, E.M.5    Shen, J.6
  • 43
    • 67749120188 scopus 로고    scopus 로고
    • Helical extension of the neuronal SNARE complex into the membrane
    • Stein, A., Weber, G., Wahl, M. C., and Jahn, R. (2009) Helical extension of the neuronal SNARE complex into the membrane. Nature 460, 525-528
    • (2009) Nature , vol.460 , pp. 525-528
    • Stein, A.1    Weber, G.2    Wahl, M.C.3    Jahn, R.4
  • 44
    • 41949130893 scopus 로고    scopus 로고
    • Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide
    • DOI 10.1038/emboj.2008.37, PII EMBOJ200837
    • Burkhardt, P., Hattendorf, D. A., Weis, W. I., and Fasshauer, D. (2008) Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J. 27, 923-933 (Pubitemid 351508147)
    • (2008) EMBO Journal , vol.27 , Issue.7 , pp. 923-933
    • Burkhardt, P.1    Hattendorf, D.A.2    Weis, W.I.3    Fasshauer, D.4
  • 45
    • 0034704771 scopus 로고    scopus 로고
    • Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
    • DOI 10.1038/35006120
    • Misura, K. M., Scheller, R. H., and Weis, W. I. (2000) Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 404, 355-362 (Pubitemid 30164329)
    • (2000) Nature , vol.404 , Issue.6776 , pp. 355-362
    • Misura, K.M.S.1    Scheller, R.H.2    Weis, W.I.3
  • 47
    • 4544227227 scopus 로고    scopus 로고
    • A role of VAMP8/Endobrevin in regulated exocytosis of pancreatic acinar cells
    • DOI 10.1016/j.devcel.2004.08.002, PII S1534580704002771
    • Wang, C. C., Ng, C. P., Lu, L., Atlashkin, V., Zhang, W., Seet, L. F., and Hong, W. (2004) A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Dev. Cell 7, 359-371 (Pubitemid 39232972)
    • (2004) Developmental Cell , vol.7 , Issue.3 , pp. 359-371
    • Wang, C.-C.1    Ng, C.P.2    Lu, L.3    Atlashkin, V.4    Zhang, W.5    Seet, L.-F.6    Hong, W.7
  • 49
    • 0027364502 scopus 로고
    • Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
    • Hata, Y., Slaughter, C. A., and Südhof, T. C. (1993) Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366, 347-351
    • (1993) Nature , vol.366 , pp. 347-351
    • Hata, Y.1    Slaughter, C.A.2    Südhof, T.C.3
  • 51
    • 78049408948 scopus 로고    scopus 로고
    • At the junction of SNARE and SM protein function
    • Carr, C. M., and Rizo, J. (2010) At the junction of SNARE and SM protein function. Curr. Opin. Cell Biol. 22, 488-495
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 488-495
    • Carr, C.M.1    Rizo, J.2
  • 53
    • 35748984692 scopus 로고    scopus 로고
    • Munc18-1 in secretion: lonely Munc joins SNARE team and takes control
    • DOI 10.1016/j.tins.2007.08.008, PII S0166223607002494
    • Toonen, R. F., and Verhage, M. (2007) Munc18-1 in secretion: lonely Munc joins SNARE team and takes control. Trends Neurosci. 30, 564-572 (Pubitemid 350051427)
    • (2007) Trends in Neurosciences , vol.30 , Issue.11 , pp. 564-572
    • Toonen, R.F.G.1    Verhage, M.2
  • 55
    • 0028924613 scopus 로고
    • Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues
    • Tellam, J. T., McIntosh, S., and James, D. E. (1995) Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. J. Biol. Chem. 270, 5857-5863
    • (1995) J. Biol. Chem. , vol.270 , pp. 5857-5863
    • Tellam, J.T.1    McIntosh, S.2    James, D.E.3
  • 57
    • 2942556680 scopus 로고    scopus 로고
    • The synaptic vesicle cycle
    • Sudhof, T. C. (2004) The synaptic vesicle cycle. Annu. Rev. Neurosci. 27, 509-547
    • (2004) Annu. Rev. Neurosci. , vol.27 , pp. 509-547
    • Sudhof, T.C.1
  • 59
    • 33845666593 scopus 로고    scopus 로고
    • Dissecting Multiple Steps of GLUT4 Trafficking and Identifying the Sites of Insulin Action
    • DOI 10.1016/j.cmet.2006.11.013, PII S1550413106003962
    • Bai, L., Wang, Y., Fan, J., Chen, Y., Ji, W., Qu, A., Xu, P., James, D. E., and Xu, T. (2007) Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab. 5, 47-57 (Pubitemid 44939397)
    • (2007) Cell Metabolism , vol.5 , Issue.1 , pp. 47-57
    • Bai, L.1    Wang, Y.2    Fan, J.3    Chen, Y.4    Ji, W.5    Qu, A.6    Xu, P.7    James, D.E.8    Xu, T.9
  • 61
    • 19744378802 scopus 로고    scopus 로고
    • Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation
    • DOI 10.1016/j.bbrc.2005.05.027, PII S0006291X05010004
    • Sano, H., Kane, S., Sano, E., and Lienhard, G. E. (2005) Synip phosphorylation does not regulate insulin-stimulated GLUT4 translocation. Biochem. Biophys. Res. Commun. 332, 880-884 (Pubitemid 40745195)
    • (2005) Biochemical and Biophysical Research Communications , vol.332 , Issue.3 , pp. 880-884
    • Sano, H.1    Kane, S.2    Sano, E.3    Lienhard, G.E.4
  • 62
    • 33746319639 scopus 로고    scopus 로고
    • A clamping mechanism involved in SNARE-dependent exocytosis
    • DOI 10.1126/science.1129450
    • Giraudo, C. G., Eng, W. S., Melia, T. J., and Rothman, J. E. (2006) A clamping mechanism involved in SNARE-dependent exocytosis. Science 313, 676-680 (Pubitemid 44201147)
    • (2006) Science , vol.313 , Issue.5787 , pp. 676-680
    • Giraudo, C.G.1    Eng, W.S.2    Melia, T.J.3    Rothman, J.E.4
  • 63
    • 33748605056 scopus 로고    scopus 로고
    • A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
    • DOI 10.1016/j.cell.2006.08.030, PII S0092867406011007
    • Tang, J., Maximov, A., Shin, O. H., Dai, H., Rizo, J., and Südhof, T. C. (2006) A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell 126, 1175-1187 (Pubitemid 44380295)
    • (2006) Cell , vol.126 , Issue.6 , pp. 1175-1187
    • Tang, J.1    Maximov, A.2    Shin, O.-H.3    Dai, H.4    Rizo, J.5    Sudhof, T.C.6
  • 65
    • 0141814988 scopus 로고    scopus 로고
    • Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic β HC-9 cell
    • DOI 10.1074/jbc.M305114200
    • Saito, T., Okada, S., Yamada, E., Ohshima, K., Shimizu, H., Shimomura, K., Sato, M., Pessin, J. E., and Mori, M. (2003) Syntaxin 4 and Synip (syntaxin 4-interacting protein) regulate insulin secretion in the pancreatic β HC-9 cell. J. Biol. Chem. 278, 36718-36725 (Pubitemid 37140004)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.38 , pp. 36718-36725
    • Saito, T.1    Okada, S.2    Yamada, E.3    Ohshima, K.4    Shimizu, H.5    Shimomura, K.6    Sato, M.7    Pessin, J.E.8    Mori, M.9
  • 66
    • 0032544441 scopus 로고    scopus 로고
    • Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A
    • Fernandez, I., Ubach, J., Dulubova, I., Zhang, X., Südhof, T. C., and Rizo, J. (1998) Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell 94, 841-849
    • (1998) Cell , vol.94 , pp. 841-849
    • Fernandez, I.1    Ubach, J.2    Dulubova, I.3    Zhang, X.4    Südhof, T.C.5    Rizo, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.