-
1
-
-
0028884033
-
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
[Medline]
-
Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. and Saltiel, A. R. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270: 27489-27494. [Medline]
-
(1995)
J. Biol. Chem
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
2
-
-
37649009049
-
Establishment of a novel high-affinity IgE receptor-positive canine mast cell line with wild-type c-kit receptors
-
[Medline] [CrossRef]
-
Amagai, Y., Tanaka, A., Ohmori, K. and Matsuda, H. 2008. Establishment of a novel high-affinity IgE receptor-positive canine mast cell line with wild-type c-kit receptors. Biochem. Biophys. Res. Commun. 366: 857-861. [Medline] [CrossRef]
-
(2008)
Biochem. Biophys. Res. Commun
, vol.366
, pp. 857-861
-
-
Amagai, Y.1
Tanaka, A.2
Ohmori, K.3
Matsuda, H.4
-
3
-
-
84864558874
-
Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
-
[Medline] [CrossRef]
-
Bachelot, T., Bourgier, C., Cropet, C., Ray-Coquard, I., Ferrero, J. M., Freyer, G., Abadie-Lacourtoisie, S., Eymard, J. C., Debled, M., Spaëth, D., Legouffe, E., Allouache, D., El Kouri, C. and Pujade-Lauraine, E. 2012. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. J. Clin. Oncol. 30: 2718-2724. [Medline] [CrossRef]
-
(2012)
J. Clin. Oncol
, vol.30
, pp. 2718-2724
-
-
Bachelot, T.1
Bourgier, C.2
Cropet, C.3
Ray-Coquard, I.4
Ferrero, J.M.5
Freyer, G.6
Abadie-Lacourtoisie, S.7
Eymard, J.C.8
Debled, M.9
Spaëth, D.10
Legouffe, E.11
Allouache, D.12
El Kouri, C.13
Pujade-Lauraine, E.14
-
4
-
-
0028360374
-
A mammalian protein target by G1-arresting rapamycin-receptor complex
-
[Medline] [CrossRef]
-
Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S. and Schreiber, S. L. 1994. A mammalian protein target by G1-arresting rapamycin-receptor complex. Nature 369: 756-758. [Medline] [CrossRef]
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
5
-
-
61449123075
-
The role of the PI3K-PKB signaling module in regulation of hematopoiesis
-
[Medline] [CrossRef]
-
Buitenhuis, M. and Coffer, P. J. 2009. The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle 8: 560-566. [Medline] [CrossRef]
-
(2009)
Cell Cycle
, vol.8
, pp. 560-566
-
-
Buitenhuis, M.1
Coffer, P.J.2
-
6
-
-
42449153345
-
Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisone: 35 cases (1997-2004)
-
[Medline] [CrossRef]
-
Camps-Palau, M. A., Leibmann, N. F., Elmslie, R., Lana, S. E., Plaza, S., McKnight, J. A., Risbon, R. and Bergman, P. J. 2007. Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisone: 35 cases (1997-2004). Vet. Comp. Oncol. 5: 156-167. [Medline] [CrossRef]
-
(2007)
Vet. Comp. Oncol
, vol.5
, pp. 156-167
-
-
Camps-Palau, M.A.1
Leibmann, N.F.2
Elmslie, R.3
Lana, S.E.4
Plaza, S.5
McKnight, J.A.6
Risbon, R.7
Bergman, P.J.8
-
7
-
-
0023927279
-
Tryptase and chymase: Comparison of extraction and release in two dog mastocytoma lines
-
[Medline]
-
Caughey, G. H., Lazarus, S. C., Viro, N. F., Gold, W. M. and Nadel, J. A. 1988. Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines. Immunology 63: 339-344. [Medline]
-
(1988)
Immunology
, vol.63
, pp. 339-344
-
-
Caughey, G.H.1
Lazarus, S.C.2
Viro, N.F.3
Gold, W.M.4
Nadel, J.A.5
-
8
-
-
33344470236
-
Integrated signaling pathways for mast-cell activation
-
[Medline] [CrossRef]
-
Gilfillan, A. M. and Tkaczyk, C. 2006. Integrated signaling pathways for mast-cell activation. Nat. Rev. Immunol. 6: 218-230. [Medline] [CrossRef]
-
(2006)
Nat. Rev. Immunol
, vol.6
, pp. 218-230
-
-
Gilfillan, A.M.1
Tkaczyk, C.2
-
9
-
-
78149397178
-
Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors
-
[Medline] [CrossRef]
-
Hahn, K. A., Legendre, A. M., Shaw, N. G., Phillips, B., Ogilvie, G. K., Prescott, D. M., Atwater, S. W., Carreras, J. K., Lana, S. E., Ladue, T., Rusk, A., Kinet, J. P., Dubreuil, P., Moussy, A. and Hermine, O. 2010. Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors. Am. J. Vet. Res. 71: 1354-1361. [Medline] [CrossRef]
-
(2010)
Am. J. Vet. Res
, vol.71
, pp. 1354-1361
-
-
Hahn, K.A.1
Legendre, A.M.2
Shaw, N.G.3
Phillips, B.4
Ogilvie, G.K.5
Prescott, D.M.6
Atwater, S.W.7
Carreras, J.K.8
Lana, S.E.9
Ladue, T.10
Rusk, A.11
Kinet, J.P.12
Dubreuil, P.13
Moussy, A.14
Hermine, O.15
-
10
-
-
47849098941
-
Vinblastine and prednisolone chemotherapy for surgically excised grade III canine cutaneous mast cell tumours
-
[Medline] [CrossRef]
-
Hayes, A., Adams, V., Smith, K., Maglennon, G. and Murphy, S. 2007. Vinblastine and prednisolone chemotherapy for surgically excised grade III canine cutaneous mast cell tumours. Vet. Comp. Oncol. 5: 168-176. [Medline] [CrossRef]
-
(2007)
Vet. Comp. Oncol
, vol.5
, pp. 168-176
-
-
Hayes, A.1
Adams, V.2
Smith, K.3
Maglennon, G.4
Murphy, S.5
-
11
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
[Medline]
-
Heinrich, M. C., Griffith, D. J., Druker, B. J., Wait, C. L., Ott, K. A. and Zigler, A. J. 2000. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96: 925-932. [Medline]
-
(2000)
Blood
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
Griffith, D.J.2
Druker, B.J.3
Wait, C.L.4
Ott, K.A.5
Zigler, A.J.6
-
12
-
-
0018927864
-
Monitoring prednisone and prednisolone
-
[Medline] [Cross-Ref]
-
Jusko, W. J. and Rose, J. Q. 1980. Monitoring prednisone and prednisolone. Ther. Drug Monit. 2: 169-176. [Medline] [Cross-Ref]
-
(1980)
Ther. Drug Monit
, vol.2
, pp. 169-176
-
-
Jusko, W.J.1
Rose, J.Q.2
-
13
-
-
52049091239
-
The multiple roles of phosphoinositide 3-kinase in mast cell biology
-
[Medline] [CrossRef]
-
Kim, M. S., Radinger, M. and Gilfillan, M. 2008. The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol. 29: 493-501. [Medline] [CrossRef]
-
(2008)
Trends Immunol
, vol.29
, pp. 493-501
-
-
Kim, M.S.1
Radinger, M.2
Gilfillan, M.3
-
14
-
-
0032905427
-
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit
-
[Medline] [CrossRef]
-
London, C. A., Galli, S. J., Yuuki, T., Hub, Z. Q., Helfand, S. C. and Geisslerb, E. N. 1999. Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp. Hematol. 27: 689-697. [Medline] [CrossRef]
-
(1999)
Exp. Hematol
, vol.27
, pp. 689-697
-
-
London, C.A.1
Galli, S.J.2
Yuuki, T.3
Hub, Z.Q.4
Helfand, S.C.5
Geisslerb, E.N.6
-
15
-
-
66649106646
-
Multi-center, placebocontrolled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision
-
[Medline] [CrossRef]
-
London, C. A., Malpas, P. B., Wood-Follis, S. L., Boucher, J. F., Rusk, A. W., Rosenberg, M. P., Henry, C. J., Mitchener, K. L., Klein, M. K., Hintermeister, J. G., Bergman, P. J., Couto, G. C., Mauldin, G. N. and Michels, G. M. 2009. Multi-center, placebocontrolled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin. Cancer Res. 15: 3856-3865. [Medline] [CrossRef]
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 3856-3865
-
-
London, C.A.1
Malpas, P.B.2
Wood-Follis, S.L.3
Boucher, J.F.4
Rusk, A.W.5
Rosenberg, M.P.6
Henry, C.J.7
Mitchener, K.L.8
Klein, M.K.9
Hintermeister, J.G.10
Bergman, P.J.11
Couto, G.C.12
Mauldin, G.N.13
Michels, G.M.14
-
16
-
-
80053343769
-
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor
-
[Medline] [Cross-Ref]
-
Ma, P., Mali, R. S., Munugalavadla, V., Krishnan, S., Ramdas, B., Sims, E., Martin, H., Ghosh, J., Li, S., Chan, R. J., Krystal, G., Craig, A. W., Takemoto, C. and Kapur, R. 2011. The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood 118: 3459-3469. [Medline] [Cross-Ref]
-
(2011)
Blood
, vol.118
, pp. 3459-3469
-
-
Ma, P.1
Mali, R.S.2
Munugalavadla, V.3
Krishnan, S.4
Ramdas, B.5
Sims, E.6
Martin, H.7
Ghosh, J.8
Li, S.9
Chan, R.J.10
Krystal, G.11
Craig, A.W.12
Takemoto, C.13
Kapur, R.14
-
17
-
-
81555204431
-
Glucocorticoid sensitivity depends on expression levels of glucocorticoid receptors in canine neoplastic mast cells
-
[Medline] [CrossRef]
-
Matsuda, A., Tanaka, A., Amagai, Y., Ohmori, K., Nishikawa, S., Xia, Y., Karasawa, K., Okamoto, N., Oida, K., Jang, H. and Matsuda, H. 2011. Glucocorticoid sensitivity depends on expression levels of glucocorticoid receptors in canine neoplastic mast cells. Vet. Immunol. Immunopathol. 144: 321-328. [Medline] [CrossRef]
-
(2011)
Vet. Immunol. Immunopathol
, vol.144
, pp. 321-328
-
-
Matsuda, A.1
Tanaka, A.2
Amagai, Y.3
Ohmori, K.4
Nishikawa, S.5
Xia, Y.6
Karasawa, K.7
Okamoto, N.8
Oida, K.9
Jang, H.10
Matsuda, H.11
-
18
-
-
13344295097
-
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
-
[Medline] [CrossRef]
-
Meydan, N., Grunberger, T., Dadi, H., Shahar, M., Arpaia, E., Lapidot, Z., Leeder, J. S., Freedman, M., Cohen, A., Gazit, A., Levitzki, A. and Roifman, C. M. 1996. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379: 645-648. [Medline] [CrossRef]
-
(1996)
Nature
, vol.379
, pp. 645-648
-
-
Meydan, N.1
Grunberger, T.2
Dadi, H.3
Shahar, M.4
Arpaia, E.5
Lapidot, Z.6
Leeder, J.S.7
Freedman, M.8
Cohen, A.9
Gazit, A.10
Levitzki, A.11
Roifman, C.M.12
-
19
-
-
78649710769
-
Mast cell homeostasis and the JAK-STAT pathway
-
[Medline] [CrossRef]
-
Morales, J. K., Falanga, Y. T., Depcrynski, A., Fernando, J. and Ryan, J. J. 2010. Mast cell homeostasis and the JAK-STAT pathway. Genes Immun. 11: 599-608. [Medline] [CrossRef]
-
(2010)
Genes Immun
, vol.11
, pp. 599-608
-
-
Morales, J.K.1
Falanga, Y.T.2
Depcrynski, A.3
Fernando, J.4
Ryan, J.J.5
-
20
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
[Medline] [CrossRef]
-
Motzer, R. J., Escudier, B., Oudard, S., Hutson, T. E., Porta, C., Bracarda, S., Grünwald, V., Thompson, J. A., Figlin, R. A., Hollaender, N., Urbanowitz, G., Berg, W. J., Kay, A., Lebwohl, D. and Ravaud, A. 2008. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 372: 449-456. [Medline] [CrossRef]
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grünwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Urbanowitz, G.11
Berg, W.J.12
Kay, A.13
Lebwohl, D.14
Ravaud, A.15
-
21
-
-
54349093009
-
Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells
-
[Medline] [CrossRef]
-
Ohmori, K., Kawarai, S., Yasuda, N., Tanaka, A., Matsuda, H., Nishimura, R., Sasaki, N., Tsujimoto, H. and Masuda, K. 2008. Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells. Vet. Immunol. Immunopathol. 126: 43-53. [Medline] [CrossRef]
-
(2008)
Vet. Immunol. Immunopathol
, vol.126
, pp. 43-53
-
-
Ohmori, K.1
Kawarai, S.2
Yasuda, N.3
Tanaka, A.4
Matsuda, H.5
Nishimura, R.6
Sasaki, N.7
Tsujimoto, H.8
Masuda, K.9
-
22
-
-
77952299648
-
Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia
-
[Medline] [CrossRef]
-
Park, S., Chapuis, N., Tamburini, J., Bardet, V., Cornillet-Lefebvre, P., Willems, L., Green, A., Mayeux, P., Lacombe, C. and Bouscary, D. 2010. Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica 95: 819-828. [Medline] [CrossRef]
-
(2010)
Haematologica
, vol.95
, pp. 819-828
-
-
Park, S.1
Chapuis, N.2
Tamburini, J.3
Bardet, V.4
Cornillet-Lefebvre, P.5
Willems, L.6
Green, A.7
Mayeux, P.8
Lacombe, C.9
Bouscary, D.10
-
23
-
-
83255167036
-
Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus
-
[Medline] [CrossRef]
-
Pavel, M. E., Hainsworth, J. D., Baudin, E., Peeters, M., Hörsch, D., Winkler, R. E., Klimovsky, J., Lebwohl, D., Jehl, V., Wolin, E. M., Oberg, K., Van Cutsem, E. and Yao, J. C. 2011. Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus. Lancet 378: 2005-2012. [Medline] [CrossRef]
-
(2011)
Lancet
, vol.378
, pp. 2005-2012
-
-
Pavel, M.E.1
Hainsworth, J.D.2
Baudin, E.3
Peeters, M.4
Hörsch, D.5
Winkler, R.E.6
Klimovsky, J.7
Lebwohl, D.8
Jehl, V.9
Wolin, E.M.10
Oberg, K.11
van Cutsem, E.12
Yao, J.C.13
-
24
-
-
0346734186
-
Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
-
[Medline]
-
Sellge, G., Lorentz, A., Gebhardt, T., Levi-Schaffer, F., Bektas, H., Manns, M. P., Schuppan, D. and Bischoff, S. C. 2004. Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor. J. Immunol. 172: 260-267. [Medline]
-
(2004)
J. Immunol
, vol.172
, pp. 260-267
-
-
Sellge, G.1
Lorentz, A.2
Gebhardt, T.3
Levi-Schaffer, F.4
Bektas, H.5
Manns, M.P.6
Schuppan, D.7
Bischoff, S.C.8
-
25
-
-
84859592965
-
Regulation of mast cell survival and function by tuberous sclerosis complex 1
-
[Medline] [CrossRef]
-
Shin, J., Pan, H. and Zhong, X. P. 2012. Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood 119: 3306-3314. [Medline] [CrossRef]
-
(2012)
Blood
, vol.119
, pp. 3306-3314
-
-
Shin, J.1
Pan, H.2
Zhong, X.P.3
-
26
-
-
1242307380
-
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
-
[Medline] [Cross-Ref]
-
Steelman, L. S., Pohnert, S. C., Shelton, J. G., Franklin, R. A., Bertrand, F. E. and McCubrey, J. A. 2004. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18: 189-218. [Medline] [Cross-Ref]
-
(2004)
Leukemia
, vol.18
, pp. 189-218
-
-
Steelman, L.S.1
Pohnert, S.C.2
Shelton, J.G.3
Franklin, R.A.4
Bertrand, F.E.5
McCubrey, J.A.6
-
27
-
-
15244341289
-
A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors
-
[Medline] [CrossRef]
-
Tanaka, A., Konno, M., Muto, S., Kambe, N., Morii, E., Nakahata, T., Itai, A. and Matsuda, H. 2005. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood 105: 2324-2331. [Medline] [CrossRef]
-
(2005)
Blood
, vol.105
, pp. 2324-2331
-
-
Tanaka, A.1
Konno, M.2
Muto, S.3
Kambe, N.4
Morii, E.5
Nakahata, T.6
Itai, A.7
Matsuda, H.8
-
28
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
[Medline]
-
Vlahos, C. J., Matter, W. F., Hui, K. Y. and Brown, R. F. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269: 5241-5248. [Medline]
-
(1994)
J. Biol. Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
29
-
-
0033976059
-
The Jak-Stat pathway in normal and perturbed hematopoiesis
-
[Medline]
-
Ward, A. C., Touw, I. and Yoshimura, A. 2000. The Jak-Stat pathway in normal and perturbed hematopoiesis. Blood 95: 19-29. [Medline]
-
(2000)
Blood
, vol.95
, pp. 19-29
-
-
Ward, A.C.1
Touw, I.2
Yoshimura, A.3
-
31
-
-
0036730274
-
Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs
-
[Medline] [CrossRef]
-
Zemke, D., Yamini, B. and Yuzbasiyan, V. 2002. Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs. Vet. Pathol. 39: 529-535. [Medline] [CrossRef]
-
(2002)
Vet. Pathol
, vol.39
, pp. 529-535
-
-
Zemke, D.1
Yamini, B.2
Yuzbasiyan, V.3
-
32
-
-
0347997608
-
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
-
[Medline] [CrossRef]
-
Zhang, W. and Liu, H. T. 2002. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12: 9-18. [Medline] [CrossRef]
-
(2002)
Cell Res
, vol.12
, pp. 9-18
-
-
Zhang, W.1
Liu, H.T.2
|