Enhanced solubility and oral absorption of sirolimus using D-α-tocopheryl polyethylene glycol succinate micelles

Artificial Cells, Nanomedicine and Biotechnology

Volumn 41, Issue 2, 2013, Pages 85-91

  Kim, Min Soo ^a   Kim, Jung Soo ^b   Cho, Won Kyung ^b,c   Hwang, Sung Joo ^c  

^a Inje University   (South Korea)

^b Chungnam National University   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Bioavailability; Micelle; Sirolimus; Stability; TPGS

Indexed keywords

BIOAVAILABILITY; CLINICAL APPLICATION; HYDRATION METHOD; MICELLAR SOLUTION; ORAL ABSORPTION; PHARMACOKINETIC STUDIES; SIROLIMUS; TPGS;

BIOCHEMISTRY; CONVERGENCE OF NUMERICAL METHODS; SOLUBILITY;

MICELLES;

RAPAMYCIN; TOCOFERSOLAN; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ABSORPTION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; MALE; MICELLE; NONHUMAN; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; RAT; SOLUBILIZATION; ZETA POTENTIAL;

ABSORPTION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; DRUG CARRIERS; DRUG STABILITY; LECITHINS; MALE; MICE; MICELLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; SOLUBILITY; VITAMIN E; WATER;

RATTUS;

EID: 84879581427     PISSN: 21691401     EISSN: 2169141X     Source Type: Journal    
DOI: 10.3109/21691401.2012.742100     Document Type: Article

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