What doesn't kill may not make you stronger: β-blockers for asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 12, 2013, Pages 1281-

  Kazani, Shamsah ^a   Israel, Elliot ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; CORTICOSTEROID; HISTAMINE; METHACHOLINE; NITRIC OXIDE; PLACEBO; PROPRANOLOL; TIOTROPIUM BROMIDE;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHOSPASM; DISEASE SEVERITY; EDITORIAL; FORCED EXPIRATORY VOLUME; HUMAN; INVERSE AGONISM; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADRENERGIC BETA-ANTAGONISTS; ASTHMA; FEMALE; HUMANS; MALE; PROPRANOLOL;

EID: 84879569437     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201305-0815ED     Document Type: Editorial

References (7)

1. Hanania NA, Dickey BF, Bond RA. Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonism. Curr Opin Pulm Med 2010;16: 1-5.
2. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci USA 2009;106: 2435-2440.
3. Hanania NA, Singh S, El-Wali R, Flashner M, Franklin AE, Garner WJ, Dickey BF, Parra S, Ruoss S, Shardonofsky F, et al. The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther 2008;21: 134-141.
4. Hanania NA, Mannava B, Franklin AE, Lipworth BJ, Williamson PA, Garner WJ, Dickey BF, Bond RA. Response to salbutamol in patients with mild asthma treated with nadolol. Eur Respir J 2010;36: 963-965.
5. Short PM, Williamson PA, Anderson WJ, Lipworth BJ. Randomized placebo-controlled trial to evaluate chronic dosing effects of propranolol in asthma. Am J Respir Crit Care Med 2013;187: 1308-1314.
6. Hauck RW, Harth M, Schulz C, Präuer H, Böhm M, Schömig A. Effects of beta 2-agonist- and dexamethasone-treatment on relaxation and regulation of beta-adrenoceptors in human bronchi and lung tissue. Br J Pharmacol 1997;121: 1523-1530.
7. Silkoff PE, McClean P, Spino M, Erlich L, Slutsky AS, Zamel N. Doseresponse relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients. Chest 2001;119: 1322-1328.